anti-Single-Minded Homolog 1 (Drosophila) (SIM1) Antibodies

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. Additionally we are shipping SIM1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIM1 6492 P81133
SIM1 20464 Q61045
SIM1 309888  
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Top anti-SIM1 Antibodies at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Pancreas 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB SIM1 Antibody (N-term)  western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SIM1 antibody detected the SIM1 protein (arrow). SIM1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SIM1 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin fixed, paraffin embedded human brain tissue stained with SIM1 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SIM1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of SIM1 Antibody (N-term) in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SIM1 antibody detected the SIM1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated IHC Mouse embryonic spinal cord- embryonic day 15 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB Western Blot: SIM1 Antibody [NBP1-97773] - NBP1-97773 (1ug/ml) staining of HEK293 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$326.89
Details
Cow Rabbit Un-conjugated ICC, IHC (p) Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with SIM1 antibody ABIN364478 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Skin (formalin-fixed, paraffin-embedded) stained with SIM1 antibody ABIN364478 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$676.50
Details
Bat Rabbit Un-conjugated WB   50 μg Log in to see 7 to 9 Days
$551.83
Details

SIM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Rat (Rattus) ,
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Top referenced anti-SIM1 Antibodies

  1. Human Polyclonal SIM1 Primary Antibody for ELISA, WB - ABIN4353806 : Ghoussaini, Stutzmann, Couturier, Vatin, Durand, Lecoeur, Degraeve, Heude, Tauber, Hercberg, Levy-Marchal, Tounian, Weill, Traurig, Bogardus, Baier, Michaud, Froguel, Meyre: Analysis of the SIM1 contribution to polygenic obesity in the French population. in Obesity (Silver Spring, Md.) 2010 (PubMed)

More Antibodies against SIM1 Interaction Partners

Human Single-Minded Homolog 1 (Drosophila) (SIM1) interaction partners

  1. identified a novel SIM1 variant, p.D134N, in 4 obese individuals from a single pedigree which is also associated with lower preference for certain foods

  2. no gene harboring deletions were identified in the SIM1 and MRAP2 regions in the Prader Willi like (PWL) cohort; further functional analysis of p.P352S found in SIM1 and p.A40S found in MRAP2 is useful; this would provide further support for possible role of SIM1 and MRAP2 in the pathogenesis of the PWL phenotype in a limited number of patients

  3. Genotype-phenotype correlations confirmed the major role for SIM1 haploinsufficiency in obesity and the Prader-Willi-like phenotype

  4. Aberrant DNA methylation (show HELLS Antibodies) of the DLX4 (show DLX4 Antibodies) and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions.

  5. Severe loss-of-function SIM1 mutations can be associated with a spectrum of developmental delay phenotypes and obesity.

  6. functional in vitro analysis of SIM1 variants may help in distinguishing benign variants of no pathogenic significance from variants which contribute to the obesity phenotype.

  7. Study found a statistically significant association between the SIM1 SNP rs3734354 (Pro352Thr) and scores for language impairment (p = .0004), but due to low statistical power this should be interpreted cautiously

  8. two brain enhancers in the SIM1 locus are characterized with a set of obesity-specific SNPs within one of them, which may predispose individuals to obesity.

  9. Data suggest selected SIM1 variants exhibit poor dimerization with ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2 (show ARNT2 Antibodies)) and anomalous intracellular localization; data were used to predict spot in SIM1/SIM2 (show SIM2 Antibodies) (residues 290-326) critical in function.

  10. Hence, we suggest that detailed endocrine evaluation and longitudinal endocrine follow up be performed in individuals with proximal interstitial 6q deletion involving SIM1

Mouse (Murine) Single-Minded Homolog 1 (Drosophila) (SIM1) interaction partners

  1. Results demonstrate that Sim1 is essential for proper migration and the guidance of commissural axons of the spinal V3 interneurons

  2. These findings reveal Sim1 as a critical yet previously unrecognized modulator of skeletal homeostasis that functions through a central relay.

  3. CB1 (show CNR1 Antibodies) receptors on Sim1-positive neurons do not impact food intake but hinder energy expenditure during dietary environmental challenges that promote body weight gain.

  4. Results show that Sim1 acts physiologically as well as developmentally to regulate body weight.

  5. Paraventricular nucleus Sim1 neuron ablation mediated obesity is resistant to high fat diet.

  6. Sim1 neurons in adult mice regulate both food intake and energy expenditure

  7. Sim1 is a regulator of dorsal raphe nucleus specification acting upstream of Pet1 (show FEV Antibodies) and Tph2 (show TPH2 Antibodies).

  8. Sim1 haploinsufficiency is thus associated with a decrease of several paraventricular nucleus and supraoptic nucleus of the hypothalamus cell types, which has the potential of affecting distinct homeostatic processes.

  9. Differential activities of murine single minded 1 (SIM1) and SIM2 (show SIM2 Antibodies) on a hypoxic response element

  10. interaction between SIM1 and arylhydrocarbon receptor involved in the control of food intake

Pig (Porcine) Single-Minded Homolog 1 (Drosophila) (SIM1) interaction partners

  1. three SIM1 genotypes (CC, CT, TT) were found and their frequencies between domestic and foreign breeds were different

SIM1 Antigen Profile

Protein Summary

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.

Gene names and symbols associated with SIM1

  • single-minded homolog 1 (Drosophila) (SIM1) antibody
  • single-minded homolog 1 (Drosophila) (Sim1) antibody
  • bHLHe14 antibody
  • mSIM1 antibody

Protein level used designations for SIM1

class E basic helix-loop-helix protein 14 , single-minded homolog 1 , single-minded 1 , single-minded-like 1

GENE ID SPECIES
100066172 Equus caballus
6492 Homo sapiens
20464 Mus musculus
481937 Canis lupus familiaris
100154026 Sus scrofa
537223 Bos taurus
309888 Rattus norvegicus
396129 Gallus gallus
100985708 Pan paniscus
472084 Pan troglodytes
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