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Sirtuin 2 Proteins (SIRT2)

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 2 Antibodies (125) and Sirtuin 2 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Top Sirtuin 2 Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 5 to 8 Days
$225.75
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$420.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,951.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,959.00
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,041.50
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,070.83
Details

SIRT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus) ,

Top referenced Sirtuin 2 Proteins

  1. Human SIRT2 Protein expressed in Escherichia coli (E. coli) - ABIN667280 : North, Marshall, Borra, Denu, Verdin: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. in Molecular cell 2003 (PubMed)
    Show all 2 references for ABIN667280

More Proteins for Sirtuin 2 (SIRT2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) interaction partners

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) interaction partners

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (show TMEM37 Proteins) expression.

Human Sirtuin 2 (SIRT2) interaction partners

  1. microseed matrix seeding (MMS) was used to obtain crystals of human Sirt3 in its apo form and of human Sirt2 in complex with ADP ribose (ADPR).

  2. Use of a pan-sirtuin (show SIRT1 Proteins) inhibitor and shRNA-mediated protein knockdown led us to uncover a role for the NAD(+)-dependent family of sirtuins, and in particular for SIRT2 and SIRT5 (show SIRT5 Proteins), in the regulation of the necroptotic cell death program

  3. Two polymorphisms,SIRT2-rs45592833 G/T and DRD2 (show DRD2 Proteins)-rs6276 A/G, provided a significant association with human longevity.

  4. Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

  5. Under hypoxic conditions, SIRT2 inhibition increased the ubiquitination of HIF-1alpha (show HIF1A Proteins) in a VHL (show VHL Proteins)-dependent manner, leading to the degradation of HIF-1alpha (show HIF1A Proteins) via a proteasomal pathway.

  6. Regulation of protein acetylation by SIRT2 plays a central role in platelet function. The effects of SIRT2 are mediated in part by the acetylation and inhibition of Akt (show AKT1 Proteins).

  7. high-resolution structures of human Sirt2 in complex with highly selective drug-like inhibitors that show a unique inhibitory mechanism, are presented.

  8. Expression of sirtuin 1 (show SIRT1 Proteins) and 2 is associated with poor prognosis in non-small cell lung cancer patients

  9. In conclusion our data reveal that resveratrol induced premature senescence is associated with SIRT1 (show SIRT1 Proteins) and SIRT2 down regulation in human dermal fibroblasts

  10. The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha (show PLA2G4A Proteins)) acts as a bridge in this complex to promote binding of SIRT2 to cyclin A (show CCNA2 Proteins)-Cdk2 (show CDK2 Proteins).

Cow (Bovine) Sirtuin 2 (SIRT2) interaction partners

  1. The results indicate that the variations in the class I sirtuin (show SIRT1 Proteins) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (show CALCA Proteins)-) diplotypes performed better than other combinations.

  3. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) interaction partners

  1. Results suggest a role for Hdac5 (show HDAC5 Proteins) and Sirt2 in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression

  2. Sirt2 deletion results in radiation-induced alteration of the mouse brain proteome.

  3. Sirt2 expression has a transitory effect in M. tuberculosis infection

  4. we postulate that Sirt2 mediates myelin-dependent neuronal dysfunction during the early phase after ischemic stroke

  5. The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha (show PLA2G4A Proteins)) acts as a bridge in this complex to promote binding of SIRT2 to cyclin A (show CCNA2 Proteins)-Cdk2 (show CDK2 Proteins).

  6. Lipopolysaccharide-induced increases in microglia NOS and cytokine mRNA were attenuated in the cells with SIRT2 silencing-produced decreases in the SIRT2 level. This suggests that SIRT2 is required for lipopolysaccharide-induced microglial activation

  7. Disruption of the SIRT2-beta-catenin (show CTNNB1 Proteins) interaction represents an endogenous therapeutic target to prevent transformation and preserve the integrity of aging cells against exogenous stressors such as reactive oxygen species.

  8. Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 (show SIRT1 Proteins) and SIRT2 pathways.

  9. long-term vitamin E-deficiency significantly decreased the expression of silent mating type information regulation (SIRT)-2 mRNA compared to short-term deficiency.

  10. data indicated that Sirt2 could enhance myoblast proliferation, shorten the G1 phase in murine C2C12 myoblasts by inducing cell cycle regulatory proteins cyclin D1 (show CCND1 Proteins) and cdk2 (show CDK2 Proteins) kinase, and suppressing p21

Sirtuin 2 (SIRT2) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Gene names and symbols associated with Sirtuin 2 Proteins (SIRT2)

  • CG5085 gene product from transcript CG5085-RA (Sirt2)
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2)
  • sirtuin 2 (sir2)
  • sirtuin 2 (SIRT2)
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2)
  • sirtuin 2 (SRT2)
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2)
  • sirtuin 2 (Sirt2)
  • 5730427M03Rik protein
  • AtSRT2 protein
  • BmSirt2 protein
  • CG5085 protein
  • D.mel2 protein
  • Dmel\\CG5085 protein
  • dSIRT2 protein
  • SIR2 protein
  • Sir2l protein
  • SIR2L2 protein
  • Sirt2 protein
  • sirtuin 2 protein
  • T2K12.8 protein
  • wu:fb57d05 protein
  • zgc:55966 protein
  • zgc:77003 protein

Protein level used designations for Sirtuin 2 Proteins (SIRT2)

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

GENE ID SPECIES
42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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