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Sirtuin 3 Proteins (SIRT3)

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Antibodies (184) and SIRT3 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top SIRT3 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   2 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details

SIRT3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced SIRT3 Proteins

  1. Human SIRT3 Protein expressed in Escherichia coli (E. coli) - ABIN667166 : Schwer, North, Frye, Ott, Verdin: The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. in The Journal of cell biology 2002 (PubMed)
    Show all 2 references for ABIN667166

  2. Human SIRT3 Protein expressed in Wheat germ - ABIN1320045 : Pacella-Ince, Zander-Fox, Lan: Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. in Human reproduction (Oxford, England) 2014 (PubMed)

More Proteins for Sirtuin 3 (SIRT3) Interaction Partners

Human Sirtuin 3 (SIRT3) interaction partners

  1. microseed matrix seeding (MMS) was used to obtain crystals of human Sirt3 in its apo form and of human Sirt2 in complex with ADP ribose (ADPR).

  2. The results suggest that NRF-2 (show GABPA Proteins) is a regulator of SIRT3 expression and may shed light on how SIRT3 is upregulated during nutrient stress.

  3. Data suggest that DNA sequence variants (DSVs) identified in myocardial infarction (MI) patients may change sirtuin 3 (SIRT3) level by affecting the transcriptional activity of SIRT3 gene promoter, contributing to the MI development as a risk factor.

  4. Studies indicate that Many of the metabolic disorders have been associated with a reduction of sirtuins SIRT1 (show SIRT1 Proteins) and SIRT3 at critical developmental windows throughout development.

  5. SIRT3 has a pro-proliferative function in melanoma

  6. Up-regulation of SIRT3 in prostate cancer suppressed the phosphorylation of Akt (show AKT1 Proteins), leading to the ubiquitination and degradation of oncoprotein c-MYC (show MYC Proteins).

  7. Study reveals a role of SIRT3/GSK-3beta/Bax (show BAX Proteins) signaling pathway in the suppression of HCC (show FAM126A Proteins) growth.

  8. physiological significance of SIRT3 on HBx-induced oxidative stress

  9. Data suggest SIRT3-mediated inhibition of cell proliferation in B-cell malignancies is dependent on down-regulation of IDH2 (show IDH2 Proteins) and SOD2 (show SOD2 Proteins) activities via deacetylation; loss of SIRT3 stimulates cell proliferation via generation of reactive oxygen species.

  10. CDK1 (show CDK1 Proteins)-mediated SIRT3 phosphorylation is a potential effective target to sensitize tumor cells to radiotherapy.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

  1. despite pre-existing defects in cardiac function and mitochondrial respiratory capacity in SIRT3(-/-) mice, SIRT3 deficiency does not additionally impair cardiac function following myocardial ischemia-reperfusion injury or following myocardial infarction

  2. In the cochlea, the expression of SIRT1 (show SIRT1 Proteins), 3, and 5 (both mRNA and protein) was decreased in the old mice

  3. SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration.

  4. Results point to an antioxidant defense mechanism presented by Sirt3 through the activation of Foxo3a (show FOXO3 Proteins), in microglia

  5. Sirt3 activation protects the heart from doxorubicin-induced cardiotoxicity by maintaining OGG1 (show OGG1 Proteins) levels and protecting mitochondria from DNA damage.

  6. CerS1 (show CERS1 Proteins), -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice.

  7. as compared to Sirt3 overexpressed and normal groups, the acetylation of IDH2 (show IDH2 Proteins) and accumulation of ox-LDL were significantly higher in the Sirt3 inhibited group

  8. Sirt3-dependent deacetylation of SOD2 (show SOD2 Proteins) plays a protective role against oxidative stress and meiotic defects in oocytes under maternal obese conditions.

  9. A mouse model of developmentally primed nonalcoholic steatohepatitis is c characterized by an altered cellular redox status, sirtuin (show SIRT1 Proteins) abundance and clock gene expression.

  10. SIRT3 deacetylated and activated GSK-3beta and thereby blocked TGF-beta1 (show TGFB1 Proteins) signaling and tissue fibrosis.

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

  1. The results indicate that the variations in the class I sirtuin (show SIRT1 Proteins) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. The expression profile of sirtuin 1 (show SIRT1 Proteins) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with Sirtuin 3 Proteins (SIRT3)

  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (sirt3)
  • sirtuin 3 (SIRT3)
  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (SIRT3)
  • sirtuin 3 (Sirt3)
  • 2310003L23Rik protein
  • AI848213 protein
  • Sir2l3 protein
  • sirtuin protein
  • zgc:158774 protein

Protein level used designations for Sirtuin 3 Proteins (SIRT3)

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPECIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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