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Sirtuin 4 Proteins (SIRT4)

SIRT4 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT4 Antibodies (107) and SIRT4 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT4 23409 Q9Y6E7
SIRT4 75387 Q8R216
SIRT4 304539  
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Top SIRT4 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 2 to 3 Days
$315.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$795.30
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,753.67
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$841.86
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details

SIRT4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Sirtuin 4 (SIRT4) Interaction Partners

Human Sirtuin 4 (SIRT4) interaction partners

  1. Thus, these results suggest that SIRT4 has essential roles in stress resistance and may be an important therapeutic target for cancer treatment.

  2. SIRT4 behaves as a tumor suppressor at the human tissue protein level.

  3. Overexpression of SIRT4 attenuated inflammation mediators in umbilical vein endothelial cells.

  4. Results show that mitochondrial sirtuins SIRT3 (show SIRT3 Proteins), SIRT4, and SIRT5 (show SIRT5 Proteins) can promote increased mitochondrial respiration and cellular metabolism and respond to excess glucose by inducing a coordinated increase of glycolysis and respiration.

  5. SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer.

  6. Serum Sirt4 was inversely related to anthropometric and metabolic parameters and positively related to peak GH and IGF-1 (show IGF1 Proteins).

  7. C-terminal-binding protein (CtBP (show CTBP2 Proteins)) was found to have an essential role in promoting glutaminolysis by directly repressing the expression of SIRT4.

  8. This study demonstrated that SIRT4 upregulation in the liver of non-alcoholic fatty liver disease patients.

  9. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH (show PDP Proteins) is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications.

  10. The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease.

Mouse (Murine) Sirtuin 4 (SIRT4) interaction partners

  1. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH (show PDP Proteins) is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications.

  2. The results of this study indicated a critical and novel stress response role for SIRT4 in promoting proper glutamate (show GRIN1 Proteins) transport capacity and protecting against excitotoxicity

  3. regulates ATP levels via ANT2 (show SLC25A5 Proteins) and a feedback loop involving AMPK (show PRKAA1 Proteins)

  4. these results highlight the tumor-suppressive role of SIRT4 in Myc-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc-induced and/or glutamine-dependent cancers.

  5. The enhanced fatty acid oxidation observed in SIRT4 knockout hepatocytes requires functional SIRT1 (show SIRT1 Proteins), demonstrating a clear cross talk between mitochondrial and nuclear sirtuins.

  6. Data uncover SIRT4 as an important component of the DNA damage response pathway that orchestrates a metabolic block in glutamine metabolism, cell cycle arrest, and tumor suppression.

  7. SIRT4 represses fatty acid oxidation and stimulates lipogenesis. SIRT4 deacetylates and represses malonyl CoA decarboxylase, regulating malonyl coA levels.

  8. Data demonstrate that SIRT4 inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle.

  9. controls insulin secretion in pancreatic beta cells; also transfers an ADP-ribosyl group from NAD to histones

  10. NAD analogues and 32P-NAD were used to study the ADP-ribosyltransferase activity of several different sirtuins, including yeast Sir2 (show SIRT1 Proteins), human SirT1 (show SIRT1 Proteins), mouse SirT4, and mouse SirT6 (show SIRT6 Proteins).

SIRT4 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Gene names and symbols associated with Sirtuin 4 Proteins (SIRT4)

  • sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) (SIRT4)
  • zgc:103539 (zgc:103539)
  • sirtuin 4 (SIRT4)
  • sirtuin 4 (Sirt4)
  • 4930596O17Rik protein
  • im:7139453 protein
  • SIR2L4 protein
  • SIRT4 protein

Protein level used designations for Sirtuin 4 Proteins (SIRT4)

sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin 4 , NAD-dependent ADP-ribosyltransferase sirtuin-4 , NAD-dependent protein deacetylase sirtuin-4 , SIR2-like protein 4 , regulatory protein SIR2 homolog 4 , sir2-like 4 , sirtuin type 4 , NAD-dependent deacetylase sirtuin-4

GENE ID SPECIES
742235 Pan troglodytes
791628 Danio rerio
100586803 Nomascus leucogenys
23409 Homo sapiens
75387 Mus musculus
304539 Rattus norvegicus
477507 Canis lupus familiaris
100125349 Sus scrofa
519328 Bos taurus
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