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Sirtuin 5 Proteins (SIRT5)

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 5 Antibodies (175) and Sirtuin 5 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
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Top Sirtuin 5 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 5 to 8 Days
$236.25
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,715.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,715.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,715.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,715.17
Details

SIRT5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Sirtuin 5 (SIRT5) Interaction Partners

Human Sirtuin 5 (SIRT5) interaction partners

  1. Use of a pan-sirtuin (show SIRT1 Proteins) inhibitor and shRNA-mediated protein knockdown led us to uncover a role for the NAD(+)-dependent family of sirtuins, and in particular for SIRT2 (show SIRT2 Proteins) and SIRT5, in the regulation of the necroptotic cell death program

  2. mutual cooperation between Y102 and R105 residues in promoting the desuccinylation versus deacetylation reaction in SIRT5.

  3. Data showed that SIRT5 was involved in protein post-translational modifications through its potent demalonylase, desuccinylase, and deglutarylase activities. Also, the protein was found in the mitochondrial, cytoplasmic, and nuclear compartments. [review]

  4. Results show that mitochondrial sirtuins SIRT3 (show SIRT3 Proteins), SIRT4 (show SIRT4 Proteins), and SIRT5 can promote increased mitochondrial respiration and cellular metabolism and respond to excess glucose by inducing a coordinated increase of glycolysis and respiration.

  5. Results suggest a role for SIRT5 in influencing oocyte quality and in vitro fertilization outcomes.

  6. SIRT1 (show SIRT1 Proteins)/SIRT5-mediated PML (show PML Proteins) deacetylation plays a role in the regulation of cancer cell survival.

  7. The results reveal the Sirt5 substrate acyl selectivity and its molecular basis and enable the design of inhibitors for Sirt5.

  8. High SIRT5 expression facilitates cancer cell growth and drug resistance in non-small cell lung cancer.

  9. Expression of SIRT5 in the entorhinal cortex, hippocampus, and white matter increases during the progression of Alzheimer disease. It is seen in activated microglia.

  10. These results reveal a novel post-translational regulation of SOD1 (show SOD1 Proteins) by means of succinylation and SIRT5-dependent desuccinylation, which is important for the growth of lung tumor cells.

Cow (Bovine) Sirtuin 5 (SIRT5) interaction partners

  1. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Mouse (Murine) Sirtuin 5 (SIRT5) interaction partners

  1. In the cochlea, the expression of SIRT1 (show SIRT1 Proteins), 3, and 5 (both mRNA and protein) was decreased in the old mice

  2. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  3. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (show SDHA Proteins)), implicating alteration in SDH (show SDS Proteins) activity as causative of the injury.

  4. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

  5. SIRT3 (show SIRT3 Proteins) and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase (show ACADVL Proteins)

  6. Pathway analysis identified glycolysis as the top SIRT5-regulated pathway. Importantly, glycolytic flux was diminished in primary hepatocytes from Sirt5(-/-) compared to WT mice.

  7. Data indicated that SIRT5 ameliorates MPTP (show PTPN2 Proteins)-induced nigrostriatal dopaminergic degeneration via preserving mitochondrial antioxidant capacity.

  8. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

  9. Loss of SIRT5 leads to accumulation of medium- and long-chain acylcarnitines and decreased beta-hydroxybutyrate production in vivo.

  10. Sirt5 is likely to be dispensable for the metabolic homeostasis under the basal conditions.

Sirtuin 5 (SIRT5) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with Sirtuin 5 Proteins (SIRT5)

  • sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) (SIRT5)
  • sirtuin 5 (CC1G_00083)
  • sirtuin 5 (sirt5)
  • sirtuin 5 (SIRT5)
  • sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) (sirt5)
  • sirtuin 5 (Sirt5)
  • 0610012J09Rik protein
  • 1500032M05Rik protein
  • AV001953 protein
  • SIR2L5 protein
  • SIRT5 protein
  • sirt5-a protein
  • zgc:92288 protein

Protein level used designations for Sirtuin 5 Proteins (SIRT5)

sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , regulatory protein SIR2 homolog 5 , sirtuin (silent mating type information regulation 2 homolog) 5 , NAD-dependent deacetylase sirtuin-5 , SIR2-like protein 5 , nad-dependent deacetylase sirtuin-5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , Regulatory protein SIR2 homolog 5

GENE ID SPECIES
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
436878 Danio rerio
23408 Homo sapiens
496346 Xenopus laevis
420834 Gallus gallus
478726 Canis lupus familiaris
100125966 Sus scrofa
507347 Bos taurus
68346 Mus musculus
306840 Rattus norvegicus
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