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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Antibodies (193) and Sirtuin 6 Kits (11) and many more products for this protein.
Showing 10 out of 24 products:
Human SIRT6 Protein expressed in Escherichia coli (E. coli) - ABIN666639
Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. in Nature 2008
Show all 2 references for ABIN666639
Human SIRT6 Protein expressed in Wheat germ - ABIN1320053
Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011
our data suggest that SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and inhibition of the activation of the JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.
SIRT6 in a protein complex with both nuclear factor erythroid 2-related factor 2 (NRF2 (show NFE2L2 Proteins)) and RNA polymerase II.
These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.
Findings suggest that polymorphisms in SIRT6/UCP1 (show UCP1 Proteins) genes may be important for increased carotid plaque burden and echodensity
Lamin A (show LMNA Proteins) promotes SIRT6-dependent DNA-PKcs (DNA-PK catalytic subunit (show PRKDC Proteins)) recruitment to chromatin.
demonstrate that PKM2 deacetylation is integral to SIRT6-mediated tumor suppression and inhibition of metastasis. Additionally, reduced SIRT6 levels correlate with elevated nuclear acetylated PKM2 levels in increasing grades of hepatocellular carcinoma
SIRT6 mutations identified in human cancers alter either SIRT6 stability, localization, or enzymatic activity. Deacetylase, not demyristoylase, activity is critical for SIRT6 tumor-suppressor.
These findings therefore provide insights into the functional interplay between SIRT6 and DNA repair mechanisms, with implications for both tumorigenesis and the treatment of multiple myeloma.
These results support a hypothesis whereby RUNX2 (show RUNX2 Proteins)-mediated repression of the SIRT6 tumor suppressor regulates metabolic pathways that promote breast cancer progression
EGF (show EGF Proteins) stimulates loss of FOXO3 (show FOXO3 Proteins)/SIRT6, which is blockaded by the inhibition of upstream pathways as well as lipid synthesis, revealing existence of a negative regulatory loop between LDs and FOXO3 (show FOXO3 Proteins)/SIRT6.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Proteins)) and management in beef cattle breeding programs.
up-regulates AMP (show TMPRSS5 Proteins)/ATP and then activates the AMPK (show PRKAA1 Proteins)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart
SIRT6 is important for glucose-stimulated insulin (show INS Proteins) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (show INS Proteins) secretion in diabetes
Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte
In SIRT6-deficient mice there is impaired bone remodeling leading to osteopenia.
SIRT6/NF-kappaB (show NFKB1 Proteins) signaling axis in ginsenoside Rg1 (show PPP1R3A Proteins)-delayed hematopoietic stem/progenitor cell senescence.
Data showed the expression levels of SIRT1 (show SIRT1 Proteins), SIRT3 (show SIRT3 Proteins), and SIRT6 were decreased in the ovaries of aged mice and mice treated with chemotherapy, but increased in mice treated to caloric restriction suggesting these genes are closely related to ovarian reserve.
Sodium sulfide (show SQRDL Proteins) protected brain endothelial cells against simulated ischemic injury through SIRT6-dependent mechanisms.
SIRT1 (show SIRT1 Proteins) localizes to the promoters of several aberrantly silenced tumor suppressor genes whose DNA is hypermethylated
Sirt6 has key roles in the relationship among ageing, metabolic syndrome, and osteoarthritis
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6