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Sirtuin 6 Proteins (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Antibodies (211) and Sirtuin 6 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  
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Top Sirtuin 6 Proteins at

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 5 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human GST tag SIRT6 protein gel. SIRT6 run on a 10% SDS-PAGE gel and stained with Coomassie blue. Arrow indicates recombinant SIRT6. 25 μg Log in to see 1 to 2 Days

SIRT6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

Rat (Rattus)

Top referenced Sirtuin 6 Proteins

  1. Human SIRT6 Protein expressed in Escherichia coli (E. coli) - ABIN666639 : Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. in Nature 2008 (PubMed)
    Show all 2 references for ABIN666639

  2. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

More Proteins for Sirtuin 6 (SIRT6) Interaction Partners

Human Sirtuin 6 (SIRT6) interaction partners

  1. this study shoes that through the antiglycolytic activity of SIRT6, the autophagy is suppressed, which is beneficial to nasal polyp formation

  2. The promoter regions of the SIRT6 gene were genetically analyzed in large cohorts of MI patients (n = 371) and ethnically-matched controls (n = 383). Results: A total of 15 DNA sequence variants (DSVs) were identified, including seven single-nucleotide polymorphisms (SNPs). Two novel heterozygous DSVs, g.4183823G>C and g.4183742G>A, were identified in two MI patients but in none of the controls.

  3. we examined the role and mechanisms of SIRT6 in suppressing postoperative epidural scar formation. We showed that SIRT6 promoted the expression of miR (show MLXIP Proteins)-21 and then suppressed TGF-beta2 (show TGFB2 Proteins) expression in a targeted manner.

  4. SIRT6 induced autophagy via attenuation of AKT signaling and treatment with autophagy inhibitor 3-MA or knockdown of autophagy-related protein Atg5 rescued H2O2-induced neuronal injury.

  5. Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Proteins)), endometrial cancer (EC) showed SIRT7 (show SIRT7 Proteins) mRNA overexpression, whereas SIRT1 (show SIRT1 Proteins), SIRT2 (show SIRT2 Proteins), SIRT4 (show SIRT4 Proteins) and SIRT5 (show SIRT5 Proteins) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 Proteins) and SIRT6.

  6. SIRT6 as an important pancreatic ductal adenocarcinoma tumor suppressor

  7. Tissue micro-array studies confirmed the higher levels of SIRT6 in both prostate tumor tissues and prostate cancer cells than in their normal counterparts. Knockdown of SIRT6 in human prostate cancer cells led to sub-G1 phase arrest of cell cycle, increased apoptosis, elevated DNA damage level and decrease in BCL2 (show BCL2 Proteins) gene expression.

  8. Results find no significant association between common polymorphisms and haplotypes in the SIRT6 gene and longevity.

  9. Data provided evidence that SIRT6 tagSNPs rs352493 and rs3760908 play significant roles in the severity of coronary artery disease (CAD) in Chinese Han subjects, which might be useful predictors of the severity of CAD.

  10. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Proteins)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. The critical role of SIRT6 on aging and inflammation.

  2. The SIRT6 regulates HSC (show FUT1 Proteins) homeostasis through the transcriptional repression of Wnt (show WNT2 Proteins) target genes. Sirt6 deletion promoted HSC (show FUT1 Proteins) proliferation through aberrant activation of Wnt (show WNT2 Proteins) signaling.

  3. Sirt6 plays a crucial role in dendritic cell differentiation and function and reduced Sirt6 activity may contribute to immunosenescence.

  4. up-regulates AMP (show TMPRSS5 Proteins)/ATP and then activates the AMPK (show PRKAA1 Proteins)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart

  5. SIRT6 is important for glucose-stimulated insulin (show INS Proteins) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (show INS Proteins) secretion in diabetes

  6. These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.

  7. Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

  8. In SIRT6-deficient mice there is impaired bone remodeling leading to osteopenia.

  9. SIRT6/NF-kappaB (show NFKB1 Proteins) signaling axis in ginsenoside Rg1 (show PPP1R3A Proteins)-delayed hematopoietic stem/progenitor cell senescence.

  10. Data showed the expression levels of SIRT1 (show SIRT1 Proteins), SIRT3 (show SIRT3 Proteins), and SIRT6 were decreased in the ovaries of aged mice and mice treated with chemotherapy, but increased in mice treated to caloric restriction suggesting these genes are closely related to ovarian reserve.

Sirtuin 6 (SIRT6) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Sirtuin 6 Proteins (SIRT6)

  • sirtuin 6 (sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 (Sirt6)
  • 2810449N18Rik protein
  • AI043036 protein
  • Sir2l6 protein

Protein level used designations for Sirtuin 6 Proteins (SIRT6)

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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