Sirtuin 6 Proteins (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Antibodies (217) and Sirtuin 6 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  
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Top Sirtuin 6 Proteins at

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 2 to 3 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days

SIRT6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced Sirtuin 6 Proteins

  1. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

More Proteins for Sirtuin 6 (SIRT6) Interaction Partners

Human Sirtuin 6 (SIRT6) interaction partners

  1. our findings describe TRF2 (show TERF2 Proteins) as a novel SIRT6 substrate and demonstrate that acetylation of TRF2 (show TERF2 Proteins) plays a crucial role in the regulation of TRF2 (show TERF2 Proteins) protein stability, thus providing a new route for modulating its expression level during oncogenesis and damage response.

  2. SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 (show HK2 Proteins) promoter chromatin structure makes it receptive to interaction with MZF1 (show ZFP42 Proteins)/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription

  3. This study demonstrates that CSNK2A1 (show CSNK2A1 Proteins) and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1 (show CSNK2A1 Proteins)-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.

  4. Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.

  5. HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (show PARP1 Proteins) and/or Sirt6..physical interaction of HBx and PARP1 (show PARP1 Proteins) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis

  6. Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (show ATG5 Proteins), LC3B (show MAP1LC3B Proteins), LAMP1 (show LAMP1 Proteins), ABCA1 (show ABCA1 Proteins), ABCG1 (show ABCG1 Proteins), and MIRN33. (ATG5 (show ATG5 Proteins) = autophagy-related protein 5 (show CAPS Proteins); LC3B (show MAP1LC3B Proteins) = microtubule-associated protein 1 light chain 3 beta (show MAP1LC3B Proteins); LAMP1 (show LAMP1 Proteins) = lysosomal-associated membrane protein 1 (show LAMP1 Proteins); ABCA1 (show ABCA1 Proteins)/ABCG1 (show ABCG1 Proteins) = ATP-binding cassette transporters 1/8)

  7. These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (show HMGB1 Proteins) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.

  8. In obese patients, the expression of Sirt6 expression is reduced.

  9. positive regulator of aldose reductase (show AKR1B1 Proteins) expression in U937 and HeLa cells under osmotic stress

  10. these results suggest that SIRT6 enhances cell aggressiveness in PTC (show F9 Proteins) via BRAF (show BRAF Proteins)/ERK (show EPHB2 Proteins)/Mcl1 (show MCL1 Proteins) pathway, and thus may be a promising target in the treatment of the disease.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Proteins)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (show INS Proteins) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.

  2. Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.

  3. Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) and endogenous production of interleukin-6 (show IL6 Proteins), which led to STAT3 (show STAT3 Proteins) activation and the positive feedback circuits for NF-kappaB (show NFKB1 Proteins) stimulation; this cross talk expedited an M1 polarization

  4. These data suggest that the function of SIRT6 in the Fabp4 (show FABP4 Proteins)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.

  5. a physiological defects in adult SIRT6-/- mice

  6. In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.

  7. It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.

  8. Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (show INS Proteins) resistance in high-fat diet-fed FKO mice.

  9. SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.

  10. Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (show INS Proteins) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.

Sirtuin 6 (SIRT6) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Sirtuin 6 Proteins (SIRT6)

  • sirtuin 6 (sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 (Sirt6)
  • 2810449N18Rik protein
  • AI043036 protein
  • Sir2l6 protein

Protein level used designations for Sirtuin 6 Proteins (SIRT6)

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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