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Sirtuin 6 Proteins (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Antibodies (210) and Sirtuin 6 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  
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Top Sirtuin 6 Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$583.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$388.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 5 to 8 Days
$236.25
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$563.20
Details
HOST_Escherichia coli (E. coli) Human GST tag SIRT6 protein gel. SIRT6 run on a 10% SDS-PAGE gel and stained with Coomassie blue. Arrow indicates recombinant SIRT6. 25 μg Log in to see 1 to 2 Days
$466.67
Details

SIRT6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced Sirtuin 6 Proteins

  1. Human SIRT6 Protein expressed in Escherichia coli (E. coli) - ABIN666639 : Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. in Nature 2008 (PubMed)
    Show all 2 references for ABIN666639

  2. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

More Proteins for Sirtuin 6 (SIRT6) Interaction Partners

Human Sirtuin 6 (SIRT6) interaction partners

  1. Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70 (show XRCC6 Proteins)) in sirtuin 6 protein (SIRT6)-depleted cells disrupt its interaction with Bax (show BAX Proteins) apoptosis regulator protein (Bax (show BAX Proteins)), which finally resulted in Bax (show BAX Proteins) mitochondrial translocalization.

  2. Taken together, these data demonstrated that astragaloside IV sensitized tumor cells to gefitinib via regulation of SIRT6, suggesting that astragaloside IV may serve as potential therapeutic approach for lung cance

  3. SIRT6 prevents matrix degradation of nucleus pulposus via the NF-kappaB (show NFKB1 Proteins) signaling pathway in intervertebral disc degeneration. SIRT6 physically interacted with nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)).

  4. The single nucleotide polymorphisms rs117385980 (C;T) in sirtuin 6 , situated 23 bases downstream of the exon 2 exon/intron border was found in heterozygous form in 1/43 longer-living healthy men (Minor allele frequency (MAF (show MAF Proteins)) 0,0116) and in 9/92 controls.

  5. In the model of CIA (show ASF1A Proteins), forced expression of SIRT6 ameliorated disease progression, osteoblastic synthesis of Cyr61 (show CYR61 Proteins), and macrophage recruitment. More importantly, expression of LDHA (show LDHA Proteins) and oxidative lesions were decreased in osteoblasts of SIRT6-treated joints. Our findings suggest that SIRT6 suppresses inflammatory response in osteoblasts via modulation of glucose metabolism and redox homeostasis.

  6. The data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acy (show ACY1 Proteins)lase activity to SIRT6's various functions.

  7. SIRT6, TNF-alpha (show TNF Proteins), and IFN-gamma (show IFNG Proteins) were significantly higher in lesional than perilesional and control skin.

  8. this study shoes that through the antiglycolytic activity of SIRT6, the autophagy is suppressed, which is beneficial to nasal polyp formation

  9. The promoter regions of the SIRT6 gene were genetically analyzed in large cohorts of MI patients (n = 371) and ethnically-matched controls (n = 383). Results: A total of 15 DNA sequence variants (DSVs) were identified, including seven single-nucleotide polymorphisms (SNPs). Two novel heterozygous DSVs, g.4183823G>C and g.4183742G>A, were identified in two MI patients but in none of the controls.

  10. we examined the role and mechanisms of SIRT6 in suppressing postoperative epidural scar formation. We showed that SIRT6 promoted the expression of miR (show MLXIP Proteins)-21 and then suppressed TGF-beta2 (show TGFB2 Proteins) expression in a targeted manner.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Proteins)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (show INS Proteins) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.

  2. SIRT6, a sirtuin (show SIRT1 Proteins) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.

  3. data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acylase (show ACY1 Proteins) activity to SIRT6's various functions

  4. Sirt6 binds to promoters of NKG2D (show KLRK1 Proteins) ligand genes and regulates the H3K9 and H3K56 acetylation levels

  5. The critical role of SIRT6 on aging and inflammation.

  6. The SIRT6 regulates HSC (show FUT1 Proteins) homeostasis through the transcriptional repression of Wnt (show WNT2 Proteins) target genes. Sirt6 deletion promoted HSC (show FUT1 Proteins) proliferation through aberrant activation of Wnt (show WNT2 Proteins) signaling.

  7. Sirt6 plays a crucial role in dendritic cell differentiation and function and reduced Sirt6 activity may contribute to immunosenescence.

  8. up-regulates AMP (show TMPRSS5 Proteins)/ATP and then activates the AMPK (show PRKAA1 Proteins)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart

  9. SIRT6 is important for glucose-stimulated insulin (show INS Proteins) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (show INS Proteins) secretion in diabetes

  10. These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.

Sirtuin 6 (SIRT6) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Sirtuin 6 Proteins (SIRT6)

  • sirtuin 6 (sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 (Sirt6)
  • 2810449N18Rik protein
  • AI043036 protein
  • Sir2l6 protein

Protein level used designations for Sirtuin 6 Proteins (SIRT6)

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

GENE ID SPECIES
444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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