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SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 7 Antibodies (172) and Sirtuin 7 Kits (13) and many more products for this protein.
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Data suggest that SIRT7 undergoes Lys (show LYZ Proteins)-63 polyubiquitination, later removed by USP7 (show USP7 Proteins) to repress enzymatic activity of SIRT7; USP7 (show USP7 Proteins) and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Proteins)); SIRT7 targets G6PC (show G6PC Proteins) promoter through ELK4 (show ELK4 Proteins). (SIRT7 = sirtuin 7; USP7 (show USP7 Proteins) = ubiquitin specific peptidase 7 (show USP7 Proteins); G6PC (show G6PC Proteins) = glucose-6-phosphatase catalytic subunit (show G6PC Proteins); ELK4 (show ELK4 Proteins) = transcription factor ELK4 (show ELK4 Proteins))
the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (show SMAD3 Proteins) levels.
SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
miR (show MLXIP Proteins)-152/SIRT7 axis plays a key role in the regulation of Human dental pulp stem cell senescence.
our study suggests that SIRT7 functions as an oncogene (show RAB1A Proteins) in non-small cell lung cancer (NSCLC), and miR (show MLXIP Proteins)-3666 can target SIRT7 to inhibit NSCLC cell growth by promoting the pro-apoptotic signaling pathway
SIRT7 trans-represses RPS7 (show RPS7 Proteins) gene in the presence of HBx protein.HBx enhances intracellular stability of SIRT7 protein.
Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Proteins)), endometrial cancer (EC) showed SIRT7 mRNA overexpression, whereas SIRT1 (show SIRT1 Proteins), SIRT2 (show SIRT2 Proteins), SIRT4 (show SIRT4 Proteins) and SIRT5 (show SIRT5 Proteins) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 Proteins) and SIRT6 (show SIRT6 Proteins).
This study showed that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.
Novel interactions of TPPII (show Tpp2 Proteins), p53 (show TP53 Proteins), and SIRT7 presented in this study might contribute to the knowledge of the regulatory effects of these proteins on apoptotic pathways and to the understanding mechanisms of aging and lifespan regulation.
SIRT7 deacetylates U3-55k (show RRP9 Proteins), enhancing U3-55k (show RRP9 Proteins) binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing.
Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 (show SIRT4 Proteins) and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 (show TDO2 Proteins) and Nnmt (show NNMT Proteins)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 (show TDO2 Proteins) and Nnmt (show NNMT Proteins) may serve as markers of HFD consumption. (Tdo2 (show TDO2 Proteins) = tryptophan 2,3-dioxygenase (show TDO2 Proteins); Nnmt (show NNMT Proteins) = nicotinamide N-methyltransferase (show NNMT Proteins))
The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (show DNMT1 Proteins) and another member of the sirtuin (show SIRT1 Proteins) family, Sirt1 (show SIRT1 Proteins).
These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 (show HIST3H3 Proteins) K18 (show KRT18 Proteins) deacetylation and the maintenance of genome integrity.
miR (show MLXIP Proteins)-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.
The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.
SIRT7 stabilizes and activates the GABP alpha (show GABPA Proteins)/GABPbeta complex via deacetylation of GABPbeta1.
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Study identifies SIRT7 as a cofactor of Myc (show MYC Proteins) for transcriptional repression and delineates a druggable regulatory branch of the ER stress response that prevents and reverts fatty liver disease.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
, sirtuin 7
, novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7)
, NAD-dependent deacetylase sirtuin-7
, NAD-dependent protein deacetylase sirtuin-7
, SIR2-like protein 7
, regulatory protein SIR2 homolog 7
, silent mating type information regulation 2, S.cerevisiae, homolog 7
, sir2-related protein type 7
, sirtuin type 7
, NAD-dependent deacetylase sirtuin 7