Sirtuin 7 Proteins (SIRT7)

SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 7 Antibodies (172) and Sirtuin 7 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT7 51547 Q9NRC8
SIRT7 209011 Q8BKJ9
SIRT7 303745  
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Top Sirtuin 7 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$295.00
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 2 to 3 Days
$495.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$768.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,107.50
Details
HOST_Baculovirus infected Insect Cells Human His tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$688.00
Details

SIRT7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Sirtuin 7 (SIRT7) Interaction Partners

Human Sirtuin 7 (SIRT7) interaction partners

  1. Data suggest that SIRT7 undergoes Lys (show LYZ Proteins)-63 polyubiquitination, later removed by USP7 (show USP7 Proteins) to repress enzymatic activity of SIRT7; USP7 (show USP7 Proteins) and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Proteins)); SIRT7 targets G6PC (show G6PC Proteins) promoter through ELK4 (show ELK4 Proteins). (SIRT7 = sirtuin 7; USP7 (show USP7 Proteins) = ubiquitin specific peptidase 7 (show USP7 Proteins); G6PC (show G6PC Proteins) = glucose-6-phosphatase catalytic subunit (show G6PC Proteins); ELK4 (show ELK4 Proteins) = transcription factor ELK4 (show ELK4 Proteins))

  2. the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (show SMAD3 Proteins) levels.

  3. SIRT7 inhibits TR4 degradation by deacetylation of DDB1.

  4. miR (show MLXIP Proteins)-152/SIRT7 axis plays a key role in the regulation of Human dental pulp stem cell senescence.

  5. our study suggests that SIRT7 functions as an oncogene (show RAB1A Proteins) in non-small cell lung cancer (NSCLC), and miR (show MLXIP Proteins)-3666 can target SIRT7 to inhibit NSCLC cell growth by promoting the pro-apoptotic signaling pathway

  6. SIRT7 trans-represses RPS7 (show RPS7 Proteins) gene in the presence of HBx protein.HBx enhances intracellular stability of SIRT7 protein.

  7. Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Proteins)), endometrial cancer (EC) showed SIRT7 mRNA overexpression, whereas SIRT1 (show SIRT1 Proteins), SIRT2 (show SIRT2 Proteins), SIRT4 (show SIRT4 Proteins) and SIRT5 (show SIRT5 Proteins) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 Proteins) and SIRT6 (show SIRT6 Proteins).

  8. This study showed that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.

  9. Novel interactions of TPPII (show Tpp2 Proteins), p53 (show TP53 Proteins), and SIRT7 presented in this study might contribute to the knowledge of the regulatory effects of these proteins on apoptotic pathways and to the understanding mechanisms of aging and lifespan regulation.

  10. SIRT7 deacetylates U3-55k (show RRP9 Proteins), enhancing U3-55k (show RRP9 Proteins) binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing.

Mouse (Murine) Sirtuin 7 (SIRT7) interaction partners

  1. Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 (show SIRT4 Proteins) and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 (show TDO2 Proteins) and Nnmt (show NNMT Proteins)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 (show TDO2 Proteins) and Nnmt (show NNMT Proteins) may serve as markers of HFD consumption. (Tdo2 (show TDO2 Proteins) = tryptophan 2,3-dioxygenase (show TDO2 Proteins); Nnmt (show NNMT Proteins) = nicotinamide N-methyltransferase (show NNMT Proteins))

  2. The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (show DNMT1 Proteins) and another member of the sirtuin (show SIRT1 Proteins) family, Sirt1 (show SIRT1 Proteins).

  3. the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (show SMAD3 Proteins) levels.

  4. SIRT7 inhibits TR4 degradation by deacetylation of DDB1.

  5. These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 (show HIST3H3 Proteins) K18 (show KRT18 Proteins) deacetylation and the maintenance of genome integrity.

  6. miR (show MLXIP Proteins)-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.

  7. The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.

  8. SIRT7 stabilizes and activates the GABP alpha (show GABPA Proteins)/GABPbeta complex via deacetylation of GABPbeta1.

  9. SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

  10. Study identifies SIRT7 as a cofactor of Myc (show MYC Proteins) for transcriptional repression and delineates a druggable regulatory branch of the ER stress response that prevents and reverts fatty liver disease.

Sirtuin 7 (SIRT7) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Gene names and symbols associated with Sirtuin 7 Proteins (SIRT7)

  • sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7)
  • novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7) (CH211-258L4.6)
  • phosphate cytidylyltransferase 2, ethanolamine (PCYT2)
  • sirtuin 7 (SIRT7)
  • sirtuin 7 (Sirt7)
  • LOC796135 protein
  • SIR2L7 protein
  • SIRT7 protein

Protein level used designations for Sirtuin 7 Proteins (SIRT7)

sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin 7 , novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7) , NAD-dependent deacetylase sirtuin-7 , sirtuin , NAD-dependent protein deacetylase sirtuin-7 , SIR2-like protein 7 , regulatory protein SIR2 homolog 7 , silent mating type information regulation 2, S.cerevisiae, homolog 7 , sir2-related protein type 7 , sirtuin type 7 , NAD-dependent deacetylase sirtuin 7

GENE ID SPECIES
454975 Pan troglodytes
796135 Danio rerio
422093 Gallus gallus
51547 Homo sapiens
209011 Mus musculus
303745 Rattus norvegicus
483371 Canis lupus familiaris
100125965 Sus scrofa
505662 Bos taurus
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