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The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. Additionally we are shipping SSH3 Antibodies (54) and SSH3 Kits (2) and many more products for this protein.
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Dephosphorylates actin-depolymerizing factor/cofilin (show CFL1 Proteins), but is not essential for viability, fertility, or development of epithelial tissues.
Expression of phosphatase-dead versions of SSH proteins, SSH1 (show SSH1 Proteins), SSH2 (show SSH2 Proteins) & SSH3 results in phosphorylation/inactivation of cofilin (show CFL1 Proteins), changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in keratinocytes.
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1\; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002
slingshot homolog 3 (Drosophila)
, protein phosphatase Slingshot homolog 3
, protein phosphatase Slingshot homolog 3-like
, SSH-like protein 3
, slingshot-like 3
, slingshot 3
, slingshot homolog 3