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acts as a ligand for glypican-1, a heparan sulfate proteoglycan\; may play a role in neurogenesis and midline development [RGD, Feb 2006].. Additionally we are shipping Slit Homolog 2 (Drosophila) Antibodies (64) and Slit Homolog 2 (Drosophila) Kits (14) and many more products for this protein.
Showing 7 out of 12 products:
These data supports a model whereby Wnt signaling through Frizzled-3a attenuates expression of Slit2 in the rostral midline of the forebrain.
In embryonic axon tracts, Robo2 (show ROBO2 Proteins) responds to signals from slit2 and slit3 (show SLIT3 Proteins).
Data show that Hedgehog (show SHH Proteins) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2, slit3 (show SLIT3 Proteins) and sema3d (show SEMA3D Proteins).
Slit acts via Robo2 (show ROBO2 Proteins) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 Proteins) and Robo3 (show ROBO3 Proteins) function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors
Overexpression of Slit2 induces its tumor suppressive effects in Breast cancer.
Significantly increased serum Slit2 (show SLIT3 Proteins) levels and hepatic expression of Slit2 (show SLIT3 Proteins) and Robo1 (show ROBO1 Proteins) were observed in patients with liver fibrosis.
our findings indicated that Slit2 (show SLIT3 Proteins)/Robo1 (show ROBO1 Proteins) axis possibly be regarded as a significant clinical parameter for predicting brain metastasis in breast cancer patients.
These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs.
VEGFR2 (show KDR Proteins) activation was not affected by Slit2 (show SLIT3 Proteins), but eNOS (show NOS3 Proteins) phosphorylation was diminished
Slit2-exon 15 splicing variants have different roles in angiogenesis and HUVEC permeability
Data indicate that SLIT2 (show SLIT3 Proteins), miR (show MLXIP Proteins)-218-1, RET (show RET Proteins)/PLAG1 (show PLAG1 Proteins) and SLIT2 (show SLIT3 Proteins)/ROBO1 (show ROBO1 Proteins) pathway involved in Hirschsprung's disease.
Slit2 (show SLIT3 Proteins)/Robo1 (show ROBO1 Proteins) signaling promotes intestinal tumorigenesis through Src (show SRC Proteins)-mediated activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
In this review, we summarize recent findings demonstrating that the neuronal guidance cues, Slit and Roundabout (show ROBO1 Proteins) (Robo), prevent the migration of multiple leukocyte subsets towards diverse inflammatory chemoattractants.
Inactivation of SLIT2 (show SLIT3 Proteins) and/or ROBO1 (show ROBO1 Proteins) is one of the early events in development of dysplastic lesions of head and neck and has prognostic importance.
Together, these observations suggest that Slit2 serves as a factor utilized by muscle Ctnnb1 (show CTNNB1 Proteins) to direct presynaptic differentiation.
Slit2 acts as a repellant cue to mediate axon guidance in the formation of the anterior commissure.
Slit2/Robo1 (show ROBO1 Proteins) signaling promotes intestinal tumorigenesis through Src (show SRC Proteins)-mediated activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
the two genes neuropeptide Y (Npy (show NPY Proteins)) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes
Data shows that modulation of angiostatic factor Slit2 by EphA2 receptor regulates endothelial responses to VEGF-mediated angiogenesis and tumor neovascularization.
administration of Slit2 to atherosclerosis-prone LDL receptor (show LDLR Proteins)-deficient mice inhibited monocyte recruitment to nascent atherosclerotic lesions.
Results provide novel evidence that low expression of SLIT2 correlates with poor prognosis and promotes metastasis in ESCC, which may be regulated by the Cdc42 (show CDC42 Proteins)-mediated pathways.
Slit2 may promote angiogenesis by upregulating Robo1 and activating the VEGFR2-ERK1/2 pathway.
Mutations of the SLIT2-ROBO2 (show ROBO2 Proteins) pathway genes SLIT2 and SRGAP1 (show SRGAP1 Proteins) confer risk for congenital anomalies of the kidney and urinary tract
Slit2 signaling through Robo1 (show ROBO1 Proteins) and Robo2 (show ROBO2 Proteins) has a role in retinal neovascularization
acts as a ligand for glypican-1, a heparan sulfate proteoglycan\; may play a role in neurogenesis and midline development
slit homolog 2 protein
, downregulated during adipocyte differentiation-1
, neurogenic extracellular slit protein