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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Additionally we are shipping KCNN3 Antibodies (19) and many more products for this protein.
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Edelfosine is able to effectively inhibit migration and invasion of UC cells in vitro and in vivo in an SK3-dependent way, pointing towards a possible role for Edelfosine as an antiinvasive drug to effectively inhibit UC cell invasion and metastasis.
KCNN3 gene encodes small conductance calcium-activated potassium (SK) channel 3
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction
Decreased SK3 expression in ganglionic bowel may explain the basis of persistent bowel symptoms in some patients following a properly performed pull-through operation for Hirschsprung's disease.
KCNN3 single-nucleotide polymorphism rs13376333 significantly increases the risk of Atrial Fibrillation.
SK3 channel and mitochondrial ROS (show ROS1 Proteins) mediate NADPH oxidase (show NOX1 Proteins)-independent NETosis induced by calcium influx.
Reduced SK3 expression attenuates endometrial cell migration and is associated with unsuccessful pregnancy outcomes.
Intermediate conductance Ca2 (show CA2 Proteins)+-activated K+ channels modulate human placental trophoblast syncytialization.
Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.
SK3 channel is activated in neuroblastoma (show ARHGEF16 Proteins) cells by overexpression of human endogenous retrovirus W family envelope gene.
SK channels (KCNN1 and KCNN3) provide a mechanism for sensing changes in intracellular Ca(2+) near the apical membrane, evoking hyperpolarization necessary for increasing the driving force for anion efflux following P2Y receptor activation [KCNN1].
Small conductance family member KCNN3 channel subtypes are activated in response to basolateral ATP challenge, essential in driving chloride secretion and thus fluid formation in the oviduct.
The data of this study implicated the family of KCNN genes in alcohol, nicotine, and drug addiction, and identify KCNN3 as a mediator of voluntary and excessive alcohol consumption
ovariectomy leads to a reduction in endothelial SK3 channel activity thereby reducing the SK3 contribution to endothelium-dependent hyperpolarization vasorelaxation.
Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.
Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 (show KCNN4 Proteins) channels
SK3 channel modulates placental vascular development and fetal health by altering VEGF signaling.
SK3 is functionally expressed in the distal nephron and collecting ducts where induction of TRPV4 (show TRPV4 Proteins)-mediated Ca2 (show CA2 Proteins)+ influx activates the channel.
SK3 channel contributes importantly towards atrial action potential repolarization.
Overexpression of the SK3 channel causes an increased risk of sudden death associated with bradyarrhythmias and heart block, possibly due to atrioventricular nodal dysfunction.
SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, small conductance calcium-activated potassium channel protein 3
, small-conductance Ca2+-activated K+ channel 3
, calcium activated potassium channel SK3
, small conductance calcium-activated potassium channel 3