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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Additionally we are shipping KCNN3 Proteins (5) and many more products for this protein.
Showing 10 out of 19 products:
Human Polyclonal KCNN3 Primary Antibody for ELISA, WB - ABIN561588
Coyle, ODonnell, Puri: Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease. in Journal of pediatric surgery 2015
Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 (show SIGMAR1 Antibodies) expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 (show SIGMAR1 Antibodies) and Orai1 (show ORAI1 Antibodies) channels was significantly correlated to a lower overall survival
Edelfosine is able to effectively inhibit migration and invasion of UC cells in vitro and in vivo in an SK3-dependent way, pointing towards a possible role for Edelfosine as an antiinvasive drug to effectively inhibit UC cell invasion and metastasis.
KCNN3 gene encodes small conductance calcium-activated potassium (SK) channel 3
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 (show KCNJ2 Antibodies) Genes and CACNG8 (show CACNG8 Antibodies)-Linked Left Ventricular Dysfunction
Decreased SK3 expression in ganglionic bowel may explain the basis of persistent bowel symptoms in some patients following a properly performed pull-through operation for Hirschsprung's disease.
KCNN3 single-nucleotide polymorphism rs13376333 significantly increases the risk of Atrial Fibrillation.
SK3 channel and mitochondrial ROS (show ROS1 Antibodies) mediate NADPH oxidase (show NOX1 Antibodies)-independent NETosis induced by calcium influx.
Reduced SK3 expression attenuates endometrial cell migration and is associated with unsuccessful pregnancy outcomes.
Intermediate conductance Ca2 (show CA2 Antibodies)+-activated K+ channels modulate human placental trophoblast syncytialization.
Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.
SK channels (KCNN1 (show KCNN1 Antibodies) and KCNN3) provide a mechanism for sensing changes in intracellular Ca(2 (show CA2 Antibodies)+) near the apical membrane, evoking hyperpolarization necessary for increasing the driving force for anion efflux following P2Y (show P2RY1 Antibodies) receptor activation [KCNN1 (show KCNN1 Antibodies)].
Small conductance family member KCNN3 channel subtypes are activated in response to basolateral ATP challenge, essential in driving chloride secretion and thus fluid formation in the oviduct.
Dynamic coupling between TRPV4 (show TRPV4 Antibodies) and Ca(2 (show CA2 Antibodies)+)-activated SK1 (show SPHK1 Antibodies)/3 and IK1 (show KCNN4 Antibodies) K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (show KCNMA1 Antibodies) in kidney collecting duct cells.
SK3 signaling microdomain modulates endothelial Ca(2+) dynamics, vascular tone, and blood pressure. SK3 knockout mice are hypertensive.
The data of this study implicated the family of KCNN genes in alcohol, nicotine, and drug addiction, and identify KCNN3 as a mediator of voluntary and excessive alcohol consumption
ovariectomy leads to a reduction in endothelial SK3 channel activity thereby reducing the SK3 contribution to endothelium-dependent hyperpolarization vasorelaxation.
Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.
Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 (show KCNN4 Antibodies) channels
SK3 channel modulates placental vascular development and fetal health by altering VEGF signaling.
SK3 is functionally expressed in the distal nephron and collecting ducts where induction of TRPV4 (show TRPV4 Antibodies)-mediated Ca2 (show CA2 Antibodies)+ influx activates the channel.
SK3 channel contributes importantly towards atrial action potential repolarization.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, small conductance calcium-activated potassium channel protein 3
, small-conductance Ca2+-activated K+ channel 3
, calcium activated potassium channel SK3
, small conductance calcium-activated potassium channel 3