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Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Additionally we are shipping SNRNP70 Antibodies (42) and SNRNP70 Kits (2) and many more products for this protein.
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These findings provide evidence for a new role of a general small nuclear ribonucleoprotein particle protein, U1C (show SNRPC Proteins), as a mediator of alternative splicing regulation.
The epitopes of U1-70K autoantibodies have been mapped at single-amino acid resolution.
The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism.
data lead to a model that FUS (show FUS Proteins) functions in coupling transcription to splicing via mediating an interaction between RNAP II and U1 snRNP (show LSM2 Proteins)
The selection of 5'-splice site nucleotides by U1 snRNP (show LSM2 Proteins) is achieved predominantly through basepairing with U1 snRNA whilst U1-C (show SNRPC Proteins) fine-tunes relative affinities of mismatched 5'-splice sites.
methylation of snRNP70 by SETMAR (show SETMAR Proteins) regulates constitutive and/or alternative splicing
U1-70K interacts with the SMN (show STMN1 Proteins) complex and is required for nuclear gem (show GEM Proteins) integrity.
Data indicate that small nuclear ribonucleoprotein U1-70K in Alzheimer disease (AD) may directly sequester normal soluble forms of U1-70K into insoluble aggregates.
These studies identify U1 snRNP (show LSM2 Proteins) pathologic changes in brain of early onset genetic forms of Alzheimer's disease
inhibition of U1 snRNP (show LSM2 Proteins) also leads to regulation of the usage of In3 pA, suggesting that the C/P activity in the cell can be cross-regulated by splicing, leading to coordination between these two processes.
High expression of U1-70K and other U1 small nuclear ribonucleoproteins spliceosome proteins in Alzheimer's disease patients and those with mild cognitive impairment.
Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
U1 small nuclear ribonucleoprotein 70 kDa
, U1 snRNP 70 kDa
, small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)
, small nuclear ribonucleoprotein 70kDa (U1)
, U1 small nuclear ribonucleoprotein polypeptide A
, U1 small ribonucleoprotein 70kd
, small nuclear ribonucleoprotein 70kDa
, U1 small nuclear ribonucleoprotein 70 kDa polypeptide A