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Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Additionally we are shipping SNRNP70 Proteins (8) and SNRNP70 Kits (2) and many more products for this protein.
Showing 10 out of 42 products:
Cow (Bovine) Polyclonal SNRNP70 Primary Antibody for WB - ABIN2778829
Dieker, Cisterna, Monneaux, Decossas, van der Vlag, Biggiogera, Muller: Apoptosis-linked changes in the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1-70K. in Cell death and differentiation 2008
Show all 5 references for ABIN2778829
Cow (Bovine) Polyclonal SNRNP70 Primary Antibody for IHC, WB - ABIN2778715
Zhang, Walker, Tamplin, Rossant, Stanford, Hughes: Zfp206 regulates ES cell gene expression and differentiation. in Nucleic acids research 2006
Show all 4 references for ABIN2778715
Human Polyclonal SNRNP70 Primary Antibody for IHC, IHC (p) - ABIN4891514
Nakaya, Alexiou, Maragkakis, Chang, Mourelatos: FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns. in RNA (New York, N.Y.) 2013
Show all 2 references for ABIN4891514
These findings provide evidence for a new role of a general small nuclear ribonucleoprotein particle protein, U1C (show SNRPC Antibodies), as a mediator of alternative splicing regulation.
The epitopes of U1-70K autoantibodies have been mapped at single-amino acid resolution.
The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism.
data lead to a model that FUS (show FUS Antibodies) functions in coupling transcription to splicing via mediating an interaction between RNAP II and U1 snRNP (show LSM2 Antibodies)
The selection of 5'-splice site nucleotides by U1 snRNP (show LSM2 Antibodies) is achieved predominantly through basepairing with U1 snRNA whilst U1-C (show SNRPC Antibodies) fine-tunes relative affinities of mismatched 5'-splice sites.
methylation of snRNP70 by SETMAR (show SETMAR Antibodies) regulates constitutive and/or alternative splicing
U1-70K interacts with the SMN (show STMN1 Antibodies) complex and is required for nuclear gem (show GEM Antibodies) integrity.
Data indicate that small nuclear ribonucleoprotein U1-70K in Alzheimer disease (AD) may directly sequester normal soluble forms of U1-70K into insoluble aggregates.
These studies identify U1 snRNP (show LSM2 Antibodies) pathologic changes in brain of early onset genetic forms of Alzheimer's disease
inhibition of U1 snRNP (show LSM2 Antibodies) also leads to regulation of the usage of In3 pA, suggesting that the C/P activity in the cell can be cross-regulated by splicing, leading to coordination between these two processes.
High expression of U1-70K and other U1 small nuclear ribonucleoproteins spliceosome proteins in Alzheimer's disease patients and those with mild cognitive impairment.
Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
U1 small nuclear ribonucleoprotein 70 kDa
, U1 snRNP 70 kDa
, small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)
, small nuclear ribonucleoprotein 70kDa (U1)
, U1 small nuclear ribonucleoprotein polypeptide A
, U1 small ribonucleoprotein 70kd
, small nuclear ribonucleoprotein 70kDa
, U1 small nuclear ribonucleoprotein 70 kDa polypeptide A