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Cross-linked envelope protein of keratinocytes. Additionally we are shipping SPRR2A Antibodies (24) and SPRR2A Kits (1) and many more products for this protein.
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SPRR2a modulates ZEB-1 signaling by way of miR-200c/141-associated epithelial mesenchyme transition through SH3-domain networks and contributes to benign and malignant wound-healing responses.
SPRR2A-associated tumor behavior was mimicked by MUC1 (show MUC1 Proteins) shRNA, which induced EMT (show ITK Proteins) and, like SPRR2A+ cells, showed reduced metastatic capabilities
SPRR2A functions as a suppressor of p53 (show TP53 Proteins)-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses.
Association of psoriasis to PGLYRP (show PGLYRP1 Proteins) and SPRR (show SPRR1A Proteins) genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Small proline-rich proteins (SPRR2A) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT (show ITK Proteins)) in cholangiocytes.
Sprr2a is selectively expressed in the upper layer of the epithelium surrounding taste buds in the circumvallate papilla
Immunohistochemical staining revealed that Sprr2a protein is detected only in the adult uterus, and not in the ovary, oviduct or testis.
In non-lesional HPV8-CER (show CBLN1 Proteins) transgenic skin StefinA and Sprr2 are indirect/direct transcriptional targets of HPV8
Data show that SPRR2a and b are allergen- and IL-13 (show IL13 Proteins)-induced in experimental allergic responses that may be involved in disease pathophysiology.
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
small proline-rich protein 2A
, type II small proline-rich protein