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Cross-linked envelope protein of keratinocytes.
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Association of psoriasis to PGLYRP (show PGLYRP1 Proteins) and SPRR (show SPRR1A Proteins) genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
, small proline-rich protein II