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Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.. Additionally we are shipping SVIP Kits (3) and and many more products for this protein.
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overexpression of gp78 (show AMFR Proteins) or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin (show SERPINA1 Proteins) deficiency
the interactions between P97 (show EIF4G2 Proteins) and these motifs, including VCP (show vcp Proteins)-binding motif (VBM) and VCP (show vcp Proteins)-interacting motif (VIM (show VIM Proteins)). The solution structures of the VBM motif from HRD1 (show SYVN1 Proteins) and the VIM (show VIM Proteins) motif from SVIP are both comprised mainly of a single alpha-helix.
A major portion of SVIP is intrinsi (show vcp Proteins)cally disordered in solution.
SVIP plays a regulatory role in p97 (show EIF4G2 Proteins) subcellular localization and is a novel regulator of autophagy.
SVIP is an endogenous inhibitor of ERAD that acts through regulating the assembly of the gp78 (show AMFR Proteins)-p97/VCP (show vcp Proteins)-Derlin1 (show DERL1 Proteins) complex.
SVIP and valosin containing protein (show vcp Proteins) were seen to be co-localized in neuronal cell bodies.
Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.