Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG8) ELISA Kits

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Additionally we are shipping SMG8 Antibodies (7) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SMG8 SMG8 55181 Q8ND04
Anti-Mouse SMG8 SMG8 74133 Q8VE18
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More ELISA Kits for SMG8 Interaction Partners

Human Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG8) interaction partners

  1. knockdown of SMG-8 produced the best effect for restoring defective mRNA and protein levels without affecting cell growth, cell-cycle progression, or endoplasmic reticulum stress in Ullrich congenital muscular dystrophy fibroblasts

  2. large-scale conformational changes induced by SMG-8 after SMG-9-mediated recruitment tune SMG-1 kinase activity to modulate nonsense-mediated mRNA decay

Caenorhabditis elegans (C. elegans) Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG8) interaction partners

  1. Results found that SMG8-SMG9 (show SMG9 ELISA Kits) is a G-domain heterodimer with architectural similarities to the dynamin-like family of GTPases. The SMG8-SMG9 (show SMG9 ELISA Kits) heterodimer forms in the absence of nucleotides. Nucleotide binding occurs at the G domain of SMG9 (show SMG9 ELISA Kits) but not of SMG8.

  2. Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay.

SMG8 Antigen Profile

Antigen Summary

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity).

Gene names and symbols associated with SMG8

  • SMG8 nonsense mediated mRNA decay factor (SMG8) antibody
  • smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans) (Smg8) antibody
  • smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans) (SMG8) antibody
  • Protein SMG-8 (smg-8) antibody
  • 1200011M11Rik antibody
  • C17orf71 antibody
  • C19H17orf71 antibody

Protein level used designations for SMG8

amplified in breast cancer gene 2 protein , protein SMG8 , protein smg-8 homolog , smg-8 homolog, nonsense mediated mRNA decay factor , CG6729 gene product

GENE ID SPECIES
55181 Homo sapiens
74133 Mus musculus
522040 Bos taurus
175103 Caenorhabditis elegans
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