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Snail Homolog 2 (Drosophila) Proteins (SNAI2)

SNAI2 encodes a member of the Snail family of C2H2-type zinc finger transcription factors.

list all proteins Gene Name GeneID UniProt
Human SNAI2 SNAI2 6591 O43623
Rat SNAI2 SNAI2 25554 O08954
Mouse SNAI2 SNAI2 20583 P97469
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More Proteins for Snail Homolog 2 (Drosophila) (SNAI2) Interaction Partners

Xenopus laevis Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.

  2. The Slug controls epithelial-mesenchymal transitions during both embryonic development and tumor metastasis.

  3. These results identify Snail2 as a key regulator of the signals involved in mesodermal induction of neural crest.

  4. A dinucleotide TGTGT/ACACA repeat in the cis (show CISH Proteins)-element of Snail2 (previously 'Slug') gene contributes to repression of neural crest cell differentiation and migration by all-trans retinoic acid in Xenopus laevis embryos.

Human Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. SLUG protein expression in primary breast cancer and axillary lymph node metastases

  2. BTBD7 expression was significantly correlated with Slug expression in SACC (P< 0.05). Increased BTBD7 expression was significantly associated with the TNM (show ODZ1 Proteins) stage, tissue typing, distant metastasis and patients' poor clinical outcome.

  3. These findings suggest that emodin inhibited the EMT (show ITK Proteins) of EOC cells via ILK (show ILK Proteins)/GSK-3beta/Slug signaling pathway

  4. ANOG was regulated by extracellular IGF signaling pathway via STAT3 (show STAT3 Proteins) phosphorylation in colorectal cancer (CRC (show CALR Proteins)). This coincides with that IGF receptor IGF-1R (show IGF1R Proteins) is often increasing expressed in malignant metastasis colon cancer. Taken together, our data define the crucial functions of IGF/STAT3 (show STAT3 Proteins)/NANOG (show NANOG Proteins)/Slug signaling axis in the progression of CRC (show CALR Proteins)

  5. These results suggest an endothelial origin of ectopic bone in early phase of traumatic heterotopic ossification and indicate that the inhibition of endothelial-mesenchymal transition by miR (show MLXIP Proteins)-630 targeting Slug plays a role in the formation of ectopic bone in heterotopic ossification.

  6. Results found an involvement of epigenetic processes in SNAIL (show SNAI1 Proteins)-induced epithelial to mesenchymal transition, highlighted by a cross-talk between SNAIL (show SNAI1 Proteins) and the histone deacetylase HDAC1 (show HDAC1 Proteins), and activation of the AKT (show AKT1 Proteins) pathway in breast cancer cells.

  7. Data show that patients with high MDA-9/Syntenin (show SDCBP Proteins) and high Slug expressions were associated with poor overall survival compared to those with low expression in lung adenocarcinomas.

  8. High SNAI2 expression was significantly correlated with Gastric Cancer.

  9. As a consequence, Slug transcription is down-regulated relieving A549 cells from Slug-mediated repression of E-cadherin transcription, thereby diminishing the metastatic potential of these oncogenic Ras-expressing NSCLC cells

  10. Sox4 was also able to promote b-catenin-mediated transcription of the Slug gene through formation of transcriptional complexes with b-catenin and p300 (show EP300 Proteins), independent of TCF4 (show TCF4 Proteins) status

Mouse (Murine) Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. The data presented here demonstrate that Snai2 and Snai3 (show SNAI3 Proteins) transcriptionally regulate the cellular fitness and functionality of not only CD4 (show CD4 Proteins)(+) regulatory T cells but effector CD8(alpha+) and CD4 (show CD4 Proteins)(+) conventional T cells as well.

  2. TGFbeta3 increases IRF6 (show IRF6 Proteins) expression and subsequently regulates SNAI2 expression; IRF6 (show IRF6 Proteins) appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.

  3. Our work demonstrates the participation of SNAI2 in the pathogenesis of luminal breast cancer, and reveals an unexpected connection between the processes of postlactational involution and breast tumorigenesis in Snai2-null mutant mice.

  4. SNAI2-driven BIM (show BCL2L11 Proteins)-induced apoptosis may temper metastasis by governing the survival of disseminating breast tumor cells.

  5. Data indicate that deletion of snail (show SNAI1 Proteins) family transcription factors Snai2 and Snai3 (show SNAI3 Proteins) in bone marrow-derived cells is sufficient to induce autoantibody generation.

  6. Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.

  7. p19(Arf) (p14(ARF) in human) stabilizes Slug to inhibit E-cadherin in prostate cancer mouse models.

  8. SNAIL (show SNAI1 Proteins) and SLUG probably play important roles during follicular development, luteinization and early embryonic development.

  9. Nanog functions in conjunction with mesenchymal factors Snai1 and Snai2 in the transcriptional regulation of pluripotency-associated genes and miRNAs during the Nanog-driven reprogramming process.

  10. pregnancy-associated mammary stem cells require a TGF-beta2 (show TGFB2 Proteins)/alphavbeta3/Slug pathway

Zebrafish Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. Snail (show SNAI1 Proteins) genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication

Snail Homolog 2 (Drosophila) (SNAI2) Protein Profile

Protein Summary

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Gene names and symbols associated with SNAI2

  • snail homolog 2 (Drosophila) (SNAI2)
  • snail family zinc finger 2 (snai2)
  • snail family zinc finger 2 (snai2-b)
  • snail family zinc finger 2 (SNAI2)
  • snail family zinc finger 2 (Snai2)
  • snail family zinc finger 2 (snai2-a)
  • snail homolog 2 (Drosophila) (Snai2)
  • snail homolog 2 (Drosophila) (snai2)
  • cb147 protein
  • cb355 protein
  • id:ibd5003 protein
  • sb:cb355 protein
  • sb:cb569 protein
  • Slug protein
  • Slugh protein
  • SLUGH1 protein
  • snai2 protein
  • SNAIL2 protein
  • WS2D protein
  • wu:fb83e12 protein
  • wu:fd19g11 protein
  • xSlu protein
  • xslug protein
  • xsna protein
  • XSnail2 protein
  • zgc:92564 protein

Protein level used designations for SNAI2

snail 2 , Protein snail-like protein 2 , zinc finger protein SNAI2 , snail homolog 2 , zinc finger transcription factor slug , zinc finger transcription factor slug beta , neural crest transcription factor SLUG , protein snail homolog 2 , slug (chicken homolog), zinc finger protein , Slug, chicken homolog , neural crest transcription factor Slug , protein slug-alpha , slug alpha , snail protein homolog Slug , xSlu , slug , zinc finger transcription factor snail 2 , zinc-finger transcription factor SLUG , slug, chicken homolog

GENE ID SPECIES
464169 Pan troglodytes
708962 Macaca mulatta
395065 Xenopus (Silurana) tropicalis
100023459 Monodelphis domestica
398235 Xenopus laevis
6591 Homo sapiens
25554 Rattus norvegicus
379440 Xenopus laevis
432368 Gallus gallus
486940 Canis lupus familiaris
641345 Sus scrofa
520631 Bos taurus
20583 Mus musculus
494038 Danio rerio
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