Snail Homolog 2 (Drosophila) Proteins (SNAI2)

SNAI2 encodes a member of the Snail family of C2H2-type zinc finger transcription factors.

list all proteins Gene Name GeneID UniProt
Human SNAI2 SNAI2 6591 O43623
Rat SNAI2 SNAI2 25554 O08954
Mouse SNAI2 SNAI2 20583 P97469
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More Proteins for Snail Homolog 2 (Drosophila) (SNAI2) Interaction Partners

Xenopus laevis Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.

  2. The Slug controls epithelial-mesenchymal transitions during both embryonic development and tumor metastasis.

  3. These results identify Snail2 as a key regulator of the signals involved in mesodermal induction of neural crest.

  4. A dinucleotide TGTGT/ACACA repeat in the cis (show CISH Proteins)-element of Snail2 (previously 'Slug') gene contributes to repression of neural crest cell differentiation and migration by all-trans retinoic acid in Xenopus laevis embryos.

Human Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. linc00261 acts a tumour suppressor in Gastric cancer by decreasing the stability of Slug proteins and suppressing epithelial-mesenchymal transition.

  2. In addition to its angiogenic action, VEGFA (show VEGFA Proteins) upregulates Sox2 (show SOX2 Proteins) to drive stem cell expansion, together with miR (show MLXIP Proteins)-452 loss and Slug upregulation, providing a novel mechanism whereby cancer stem cells acquire metastatic potential.

  3. Slug is a positive regulator, and Snail (show SNAI1 Proteins) a negative regulator, of PLD2 (show PLD2 Proteins) expression.

  4. miR (show MLXIP Proteins)-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C (show TFAP2C Proteins) in non-small cell lung cancer cells.

  5. Data suggested that CCL18 (show CCL18 Proteins) upregulated Slug expression to promote epithelial-mesenchymal transition (EMT (show ITK Proteins)) and stem cell-like features by activating the mTOR (show FRAP1 Proteins) pathway in oral cancer.

  6. UCA1 overexpression promoted cell epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma via effectively sponging to miR-203 and thereby activating the expression of transcription factor Snail2.

  7. High SLUG expression is associated with lung metastasis in ovarian cancer.

  8. overexpression of miR (show MLXIP Proteins)-218 in H1299 increased chemosensitivity of cells to cisplatin treatment through suppression of Slug and ZEB2. These findings highlight an important role of miR (show MLXIP Proteins)-218 in the regulation of EMT (show ITK Proteins)-related traits and metastasis of lung cancer in part by modulation of Slug/ZEB2 signaling, and provide a potential therapeutic strategy by targeting miR (show MLXIP Proteins)-218 in lung cancer.

  9. regulation of cancer stem cell via SLUG-SOX9 (show SOX9 Proteins) regulatory axis

  10. our current findings highlight how Slug functions as an important transcriptional repressor that finely regulates the SCF/c-Kit signaling pathway.

Mouse (Murine) Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. our current findings highlight how Slug functions as an important transcriptional repressor that finely regulates the SCF/c-Kit signaling pathway.

  2. Slug emerges as a key transcription factor driving smooth muscle cell towards a proliferative phenotype.

  3. both Snail (show SNAI1 Proteins) and Slug are able to form binary complexes with either YAP (show YAP1 Proteins) or TAZ (show TAZ Proteins) that, together, control YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) transcriptional activity and function throughout mouse development.

  4. results demonstrate that skeletal stem/stromal cell mobilize Snail (show SNAI1 Proteins)/Slug-YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) complexes to control stem cell function

  5. The data presented here demonstrate that Snai2 and Snai3 (show SNAI3 Proteins) transcriptionally regulate the cellular fitness and functionality of not only CD4 (show CD4 Proteins)(+) regulatory T cells but effector CD8(alpha+) and CD4 (show CD4 Proteins)(+) conventional T cells as well.

  6. TGFbeta3 increases IRF6 (show IRF6 Proteins) expression and subsequently regulates SNAI2 expression; IRF6 (show IRF6 Proteins) appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.

  7. Our work demonstrates the participation of SNAI2 in the pathogenesis of luminal breast cancer, and reveals an unexpected connection between the processes of postlactational involution and breast tumorigenesis in Snai2-null mutant mice.

  8. SNAI2-driven BIM (show BCL2L11 Proteins)-induced apoptosis may temper metastasis by governing the survival of disseminating breast tumor cells.

  9. Data indicate that deletion of snail (show SNAI1 Proteins) family transcription factors Snai2 and Snai3 (show SNAI3 Proteins) in bone marrow-derived cells is sufficient to induce autoantibody generation.

  10. Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.

Zebrafish Snail Homolog 2 (Drosophila) (SNAI2) interaction partners

  1. Snail (show SNAI1 Proteins) genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication

Snail Homolog 2 (Drosophila) (SNAI2) Protein Profile

Protein Summary

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Gene names and symbols associated with SNAI2

  • snail homolog 2 (Drosophila) (SNAI2)
  • snail family zinc finger 2 (snai2)
  • snail family zinc finger 2 (snai2-b)
  • snail family zinc finger 2 (SNAI2)
  • snail family zinc finger 2 (Snai2)
  • snail family zinc finger 2 (snai2-a)
  • snail homolog 2 (Drosophila) (Snai2)
  • snail homolog 2 (Drosophila) (snai2)
  • cb147 protein
  • cb355 protein
  • id:ibd5003 protein
  • sb:cb355 protein
  • sb:cb569 protein
  • Slug protein
  • Slugh protein
  • SLUGH1 protein
  • snai2 protein
  • SNAIL2 protein
  • WS2D protein
  • wu:fb83e12 protein
  • wu:fd19g11 protein
  • xSlu protein
  • xslug protein
  • xsna protein
  • XSnail2 protein
  • zgc:92564 protein

Protein level used designations for SNAI2

snail 2 , Protein snail-like protein 2 , zinc finger protein SNAI2 , snail homolog 2 , zinc finger transcription factor slug , zinc finger transcription factor slug beta , neural crest transcription factor SLUG , protein snail homolog 2 , slug (chicken homolog), zinc finger protein , Slug, chicken homolog , neural crest transcription factor Slug , protein slug-alpha , slug alpha , snail protein homolog Slug , xSlu , slug , zinc finger transcription factor snail 2 , zinc-finger transcription factor SLUG , slug, chicken homolog

GENE ID SPECIES
464169 Pan troglodytes
708962 Macaca mulatta
395065 Xenopus (Silurana) tropicalis
100023459 Monodelphis domestica
398235 Xenopus laevis
6591 Homo sapiens
25554 Rattus norvegicus
379440 Xenopus laevis
432368 Gallus gallus
486940 Canis lupus familiaris
641345 Sus scrofa
520631 Bos taurus
20583 Mus musculus
494038 Danio rerio
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