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SHOC2 encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. Additionally we are shipping Soc-2 Suppressor of Clear Homolog (C. Elegans) Proteins (4) and many more products for this protein.
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Human Polyclonal SHOC2 Primary Antibody for EIA, IHC (p) - ABIN500706
Sieburth, Sun, Han: SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. in Cell 1998
Show all 4 references for ABIN500706
Human Polyclonal SHOC2 Primary Antibody for EIA, IHC (fro) - ABIN1109005
Matsunaga-Udagawa, Fujita, Yoshiki, Terai, Kamioka, Kiyokawa, Yugi, Aoki, Matsuda: The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. in The Journal of biological chemistry 2010
Data suggest that SUR-8 may act in an ERK (show EPHB2 Antibodies)-independent pathway to regulate AVC development.
Erbin (show ERBB2IP Antibodies) has a regulatory role in the Ras-Raf (show RAF1 Antibodies)-MEK (show MDK Antibodies) pathway and may inhibit ERK (show EPHB2 Antibodies) activation by disrupting the Sur-8-Ras/Raf (show RAF1 Antibodies) interaction
results demonstrate that PSMC5 (show PSMC5 Antibodies) is a new and important player involved in regulating ERK1/2 (show MAPK1/3 Antibodies) signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner.
Noonan-like syndrome has been related to the invariant c.4A > G missense change in SHOC2.
Two unrelated Taiwanese patients have been described with Noonan-like syndrome with loose anagen hair who also have moyamoya disease and in whom heterozygous germline mutation in SHOC2 was found.
ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of Epidermal Growth Factor (show EGF Antibodies), a stimulus that induces proliferation rather than differentiation in these cells.
Extreme phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation in Noonan-like syndrome with loose anagen hair.
A newborn heterozygous for the invariant c.4A>G missense change in SHOC2.
Data show that both Shoc2 and HUWE1 (show HUWE1 Antibodies) are necessary to control the levels and ubiquitination of the Shoc2 signaling partner, RAF-1 (show RAF1 Antibodies).
Both MRAS (show MRAS Antibodies) and SHOC2 play a key role in polarized migration.
SHOC2 and CRAF (show RAF1 Antibodies) mediate ERK1/2 (show MAPK1/3 Antibodies) reactivation in mutant NRAS (show NRAS Antibodies)-mediated resistance to RAF (show RAF1 Antibodies) inhibitor.
targeting of Shoc2 to late endosomes may facilitate EGFR (show EGFR Antibodies)-induced ERK (show EPHB2 Antibodies) activation under physiological conditions of cell stimulation by EGF (show EGF Antibodies), and therefore, may be involved in the spatiotemporal regulation of signaling through the RAS-RAF (show RAF1 Antibodies) module
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
Ras-binding protein SUR-8
, leucine-rich repeat protein SHOC-2
, protein soc-2 homolog
, protein sur-8 homolog
, suppressor of clear, C. elegans, homolog of
, Protein soc-2 homolog
, Protein sur-8 homolog