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Sodium Channel, Nonvoltage-Gated 1, beta Proteins (SCNN1B)

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Additionally we are shipping SCNN1B Antibodies (124) and SCNN1B Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCNN1B 6338 P51168
SCNN1B 20277 Q9WU38
Rat SCNN1B SCNN1B 24767 P37090
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Top SCNN1B Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,137.67
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,552.00
Details

SCNN1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) Interaction Partners

Human Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) interaction partners

  1. Three nonsynonymous amino acid variants in SCNN1B in nonwhite Cystic fibrosis (show S100A8 Proteins) patients with non-diagnostic CFTR (show CFTR Proteins) genotypes was

  2. These results do not suggest an important role for the T594M variant of the ENaC (show SCNN1A Proteins) gene contributing to either the development or severity of hypertension in subjects of Indo (show IDO1 Proteins)-Aryan ancestry.

  3. The transcriptional expression of alpha, beta, and gamma subunits of ENaC (show SCNN1A Proteins) was elevated in nasal polyp compared to nasal mucosa

  4. causative mutation for Liddle's syndrome (LS) in this patient was identified to be a novel frameshift mutation. DNA sequencing resulted in exon 13 of SCNN1B gene: SCNN1B NM_000336.2:c.1 724_1730dupGGCCCAC [p.Pro5 75Argfs*17].

  5. analysis of a novel frameshift mutation in the betaENaC gene in an isolated case of Liddle syndrome

  6. Suggest that SCNN1B gene has important roles in blood pressure regulation in the Han Chinese population.

  7. significant association between the rs3743966 SNP in intron 12 of epithelial sodium channel beta-subunit and essential hypertension

  8. Suggest that beta-ENaC mediates cytotrophoblast migration and increasing beta-ENaC expression by HO-1 (show HMOX1 Proteins) induction enhances migration.

  9. ENaCbeta but not ENaCalpha (show SCNN1A Proteins) expression is significantly lower in severe preeclampsia compared with normal pregnancy.

  10. WNK4 (show WNK4 Proteins) inhibits ENaC (show SCNN1A Proteins) channel activity independently of Nedd4-2 (show NEDD4L Proteins)-mediated ENaC (show SCNN1A Proteins) ubiquitination.

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) interaction partners

  1. Nedd4-2 (show NEDD4L Proteins)-mediated ubiquitination of beta-ENaC leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.

  2. Data indicate that insulin receptor (InsR (show INSR Proteins)) is important for epithelial sodium channel (ENaC (show SCNN1A Proteins)) activity.

  3. Our findings are consistent with the role of betaENaC as a vascular smooth muscle cell mechanosensor and function of evolutionarily related nematode degenerin (show ACCN1 Proteins) proteins.

  4. These data suggest that adenylyl cyclase VI mediates vasopressin (show AVP Proteins)-stimulated ENaC (show SCNN1A Proteins) activity in the kidney.

  5. Cys (show DNAJC5 Proteins) substitutions at sites in the wrist domains of the beta and gamma subunits alter the Na+ self-inhibition response.

  6. ENaC (show SCNN1A Proteins) is not a passive passenger in regulated epithelial vesicle trafficking, but plays a role in establishing and maintaining the pool of vesicles that respond to cAMP stimulation.

  7. These findings demonstrate that myogenic constriction in afferent arterioles is dependent on normal expression of betaENaC

  8. loss of beta-ENaC associated with early signs of renal injury and increased mean arterial pressure

  9. generation of transgenic mice with airway-specific overexpression of the epithelial Na(+) channel (ENaC (show SCNN1A Proteins)) is an alternative approach to mimic cystic fibrosis (show S100A8 Proteins) ion transport pathophysiology in the lung

  10. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.

SCNN1B Protein Profile

Protein Summary

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.

Gene names and symbols associated with SCNN1B

  • sodium channel, non-voltage-gated 1, beta subunit (SCNN1B)
  • sodium channel, non-voltage-gated 1, beta subunit (scnn1b)
  • sodium channel, nonvoltage-gated 1, beta (SCNN1B)
  • sodium channel, nonvoltage-gated 1 beta (Scnn1b)
  • sodium channel, nonvoltage-gated 1, beta (Scnn1b)
  • BESC1 protein
  • BETA-ENAC protein
  • ENaCb protein
  • ENaCbeta protein
  • RNENACB protein
  • SCNEB protein
  • SCNN1B protein

Protein level used designations for SCNN1B

sodium channel, nonvoltage-gated 1, beta , sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) , amiloride-sensitive sodium channel subunit beta , amiloride-sensitive sodium channel subunit beta 1 , beta-ENaC , beta-NaCH , epithelial Na(+) channel subunit beta , epithelial sodium channel beta-2 subunit , epithelial sodium channel beta-3 subunit , nasal epithelial sodium channel beta subunit , nonvoltage-gated sodium channel 1 subunit beta , Amiloride-sensitive sodium channel subunit beta , epithelial amiloride-sensitive sodium channel beta subunit , SCNEB , epithelial sodium channel ENaC beta subunit , epithelial sodium channel, beta subunit , amiloride sensitive epithelial sodium ion channel beta subunit , epithelium sodium channel beta subunit , ENaC beta , amiloride sensitive sodium channel beta1 subunit , sodium channel, nonvoltage-gated, type I, beta

GENE ID SPECIES
100069008 Equus caballus
453984 Pan troglodytes
700093 Macaca mulatta
779891 Xenopus (Silurana) tropicalis
100476005 Ailuropoda melanoleuca
100590266 Nomascus leucogenys
6338 Homo sapiens
489972 Canis lupus familiaris
100009564 Oryctolagus cuniculus
100627971 Sus scrofa
100170325 Ovis aries
20277 Mus musculus
100270805 Cavia porcellus
24767 Rattus norvegicus
533355 Bos taurus
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