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Sodium Channel, Nonvoltage-Gated 1 alpha Proteins (SCNN1A)

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Additionally we are shipping SCNN1A Antibodies (84) and SCNN1A Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCNN1A 6337 P37088
SCNN1A 20276 Q61180
Rat SCNN1A SCNN1A 25122 P37089
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Top SCNN1A Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

SCNN1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaction Partners

Rabbit Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

Human Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. Four nonsynonymous amino acid variants in SCNN1A in nonwhite Cystic fibrosis (show S100A8 Proteins) patients with non-diagnostic CFTR (show CFTR Proteins) genotypes was identified.

  2. The rs4149570 and rs7956915 polymorphisms of SCNN1A might play important roles in the susceptibility to respiratory distress syndrome, particularly in term infants.

  3. These results indicate that ENaC functions as a sensor for external Cd2 (show CD2 Proteins)+.

  4. The transcriptional expression of alpha, beta, and gamma subunits of ENaC was elevated in nasal polyp compared to nasal mucosa

  5. The long isoform of alphaENaC forms the structural basis of a channel with different activity and regulation, which may not be easily distinguishable in native tissue, but may underlie sodium hyperabsorption and salt sensitive differences in humans.

  6. ENaC regulates miR (show MLXIP Proteins)-101/miR (show MLXIP Proteins)-199a-3p during embryo implantation with the involvement of CREB (show CREB1 Proteins) phosphorylation.

  7. Five de novo mutations were identified in four genes (SCNN1A, KCNJ16 (show KCNJ16 Proteins), KCNB2 (show KCNB2 Proteins), and KCNT1 (show KCNT1 Proteins)) in three Brugada syndrome patients

  8. ASIC1A (show ACCN2 Proteins) and ENaCalpha form functional heterotrimers acting as ion channels.

  9. SCNN1A and SCNN1G SNPs may contribute to blood pressure changes over time in the Han Chinese population.

  10. Skin hydration status regulates sodium homeostasis and inflammatory pathways through the epithelial sodium channel (ENaC).

Xenopus laevis Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. reducing ENaC expression in the connecting tubule induces clear pseudohypoaldosteronism type 1 symptoms during high dietary potassium loading

  2. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  3. PCSK9 (show PCSK9 Proteins)(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC under basal condition

  4. H-Ras (show HRAS Proteins) mediates the inhibitory effect of epidermal growth factor (show EGF Proteins) on the epithelial Na+ channel

  5. 17beta-estradiol attenuates LPS (show TLR4 Proteins)-induced acute lung injury via PI3K/Akt (show AKT1 Proteins)/SGK1 (show SGK1 Proteins) mediated up-regulation of Scnn1a.

  6. ENaC regulates miR (show MLXIP Proteins)-101/miR (show MLXIP Proteins)-199a-3p during embryo implantation with the involvement of CREB (show CREB1 Proteins) phosphorylation.

  7. Pendrin (show SLC26A4 Proteins) gene ablation reduced ENaC-mediated Na(+) absorption by reducing channel open probability as well as by reducing channel density through changes in subunit total protein abundance and subcellular distribution.

  8. results are consistent with a role of alphaENaC in connecting tubule in rosiglitazone-induced fluid retention, which dovetails with the physiological relevance of ENaC in this segment

  9. In the absence of Na(+)-HCO3 (-) cotransporter (show SLC4A4 Proteins) electrogenic 2 in the late distal tubule, acid-loaded mice exhibit disinhibition of ENaC-mediated Na(+) reabsorption, which results in Na(+) retention, K(+) wasting, and hypertension.

  10. sustained stimulatory effect of locally elevated norepinephrine on ENaC-mediated Na(+) absorption may contribute to the hypertensive effect of increased renal sympathetic activity

Guinea Pig Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. Different subunits of ENaC expressed in various cell regions of the cochlea and endolymphatic sac (show ADCY10 Proteins) in distinct patterns may form the functional sodium channel to regulate the endolymph and maintain homeostasis in inner ear.

SCNN1A Protein Profile

Protein Summary

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with SCNN1A

  • sodium channel, non-voltage-gated 1 alpha subunit (SCNN1A)
  • sodium channel, nonvoltage-gated 1 alpha (SCNN1A)
  • sodium channel, nonvoltage-gated 1 alpha (LOC100222046)
  • epithelial sodium channel, alpha subunit (ALPHA-ENAC)
  • sodium channel, non-voltage-gated 1 alpha subunit (scnn1a)
  • sodium channel, nonvoltage-gated 1, delta (SCNN1D)
  • sodium channel, nonvoltage-gated 1 alpha (Scnn1a)
  • alphaxENaC protein
  • besc2 protein
  • ENAC protein
  • enaca protein
  • ENaCalpha protein
  • mENaC protein
  • SCNEA protein
  • Scnn1 protein
  • SCNN1A protein

Protein level used designations for SCNN1A

alpha-subunit renal epithelial sodium channel , amiloride-sensitive sodium channel subunit alpha , sodium channel, nonvoltage-gated 1 alpha , alpha ENaC , epithelial sodium channel alpha subunit , epithelium sodium channel alpha subunit , sodium channel, nonvoltage-gated 1, alpha , amiloride-sensitive sodium channel alpha subunit , SCNEA , alpha-NaCH , epithelial Na(+) channel subunit alpha , epithelial sodium channel ENaC alpha subunit , nonvoltage-gated sodium channel 1 subunit alpha , alpha ENaC-2 , alpha-ENaC , amiloride-sensitive epithelial sodium channel alpha subunit , amiloride-sensitive sodium channel subunit alpha 2 , nasal epithelial sodium channel alpha subunit , alpha cENaC 431 , amiloride-sensitve epithelial sodium channel alpha subunit , sodium channel, nonvoltage-gated 1, delta , ENaC alpha , amiloride-sensitive epithelial sodium channel , sodium channel, nonvoltage-gated, type I, alpha polypeptide , sodium channel, nonvoltage-gated, type I, alpha

GENE ID SPECIES
396608 Sus scrofa
403650 Canis lupus familiaris
443488 Ovis aries
451776 Pan troglodytes
100222046 Taeniopygia guttata
100484947 Ailuropoda melanoleuca
100014763 Monodelphis domestica
100009488 Oryctolagus cuniculus
6337 Homo sapiens
282348 Bos taurus
396050 Gallus gallus
397811 Xenopus laevis
428184 Gallus gallus
20276 Mus musculus
25122 Rattus norvegicus
100135613 Cavia porcellus
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