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anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Antibodies

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Additionally we are shipping Sodium Channel, Voltage-Gated, Type I, alpha Subunit Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN1A 20265  
SCN1A 81574 P04774
SCN1A 6323 P35498
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Top anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of Scn1a expression in rat brain extract (lane 1), mouse brain extract (lane 2) and U87 whole cell lysates (lane 4). Scn1a at 250KD was detected using rabbit anti- Scn1a Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p) 1 mL Log in to see 6 to 8 Days
$599.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-SCN1A / Nav1.1 antibody  ABIN1049319 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Nav1.1 expression in SHSY5Y (A), mouse brain (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SCN1A / Nav1.1 antibody IHC staining of human pancreas, exocrine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1104128 concentration 20 ug/ml. 100 μL Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB Pancreas stained in IHC-P with SCN1A antibody 0.1 mg Log in to see 6 to 8 Days
$555.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, WB   100 μg Log in to see 8 to 10 Days
$625.17
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Mouse Un-conjugated IP, IHC, WB   100 μg Log in to see 8 to 10 Days
$537.17
Details

SCN1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Antibodies

  1. Human Polyclonal SCN1A Primary Antibody for IHC, WB - ABIN350849 : Lu, Han, Rado, Brown: Differential expression of two sodium channel subtypes in human brain. in FEBS letters 1992 (PubMed)
    Show all 5 references for ABIN350849

More Antibodies against Sodium Channel, Voltage-Gated, Type I, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. findings establish an unexpected role for Nav1.1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain

  2. Deletion of Nav1.1 channels selectively impairs excitability of GABAergic interneurons

  3. Results show Nav1.1 haploinsufficiency in excitatory neurons has an ameliorating effect on the pathology of Dravet syndrome.

  4. These results establish a direct role for SCN1A in the regulation of sleep

  5. Loss of NaV1.1 channels in forebrain GABAergic neurons is both necessary and sufficient to cause epilepsy and premature death in Dravet syndrome.

  6. mice with Scn1a haploinsufficiency exhibit hyperactivity, stereotyped behaviours, social interaction deficits and impaired context-dependent spatial memory; results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome

  7. These results demonstrate increased expression levels of Nav1.7 (show SCN9A Antibodies), Nav1.8 (show SCN10A Antibodies), and perhaps Nav1.1 in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 (show NF1 Antibodies) gene

  8. Na(V)1.1 channels are expressed in the suprachiasmatic nucleus (SCN (show SRI Antibodies)) of the hypothalamus.

  9. a mechanism consistent with BACE1 (show BACE Antibodies) activity regulating mRNA levels of the alpha-subunit (show POLG Antibodies) Na(v)1.1 via cleavage of cell-surface Na(v)beta(2).

  10. We describe a Roma/Gypsy family, where a missense mutation in SCN1A, p.D194N, is transmitted from a mosaic GEFS+ father to a child with Dravet syndrome.

Human Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. Mutations in SCN1A, the gene that encodes the alpha subunit (show POLG Antibodies) of voltage-gated sodium channel Nav1.1, can cause epilepsies.

  2. Retrospective study to survey the efficacy of antiepileptic drugs in Dravet syndrome with different SCN1A genotypes

  3. No causative variants were identified in any of non-DS epileptic patients in our cohort, suggesting a minor, but not irrelevant role for SCN1A in patients with other types of childhood epilepsy.

  4. Mutations in SCN1A and SCN2A (show SCN2A Antibodies) are a predisposing factor of acute encephalopathy with biphasic seizures and late reduced diffusion

  5. Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes.

  6. The SCN1A IVS5-91G>A SNP is associated with susceptibility to epilepsy. SNPs in EPHX1 (show EPHX1 Antibodies) gene are influencing CBZ metabolism and disposition

  7. Human Nav1.6 (show SCN8A Antibodies) channels generate larger resurgent currents than human Nav1.1 channels, but the SCN4B (show SCN4B Antibodies)-derived Navbeta4 (show SCN4B Antibodies) peptide does not protect either isoform from use-dependent reduction.

  8. We report the association of two novel homozygous missense mutations of the SCN1A gene in four children with infantile epilepsies from two consanguineous pedigrees

  9. This study provide the evidence SCN1A mutation releate to Autism Spectrum Disorder.

  10. Molecular genetic testing detected a de novo SCN1A gene deletion in heterozygous form, and revealed SCN1A gene associated monogenic epileptic syndrome being in the genetic background of therapy-resistant seizures.

Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Antigen Profile

Protein Summary

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.

Gene names and symbols associated with SCN1A

  • sodium channel, voltage-gated, type I, alpha subunit (SCN1A) antibody
  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A) antibody
  • sodium channel, voltage-gated, type I, alpha (Scn1a) antibody
  • B230332M13 antibody
  • EIEE6 antibody
  • FEB3 antibody
  • FEB3A antibody
  • FHM3 antibody
  • GEFSP2 antibody
  • HBSCI antibody
  • NAC1 antibody
  • Nav1.1 antibody
  • SCN1 antibody
  • SCN1A antibody
  • SCN9A antibody
  • SMEI antibody

Protein level used designations for SCN1A

sodium channel, voltage-gated, type IX, alpha subunit , voltage-gated sodium channel I , sodium channel, voltage-gated, type I, alpha subunit , sodium channel protein brain I subunit alpha , sodium channel protein type 1 subunit alpha , sodium channel protein type I subunit alpha , sodium channel protein, brain I subunit alpha , sodium channel voltage-gated type I alpha polypeptide , sodium channel, voltage-gated, type 1, alpha polypeptide , sodium channel, voltage-gated, type I, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.1 , sodium channel protein, brain I alpha subunit , sodium channel voltage gated type 1 alpha subunit , sodium channel voltage-gated type I alpha

GENE ID SPECIES
100052059 Equus caballus
395946 Gallus gallus
20265 Mus musculus
81574 Rattus norvegicus
6323 Homo sapiens
478775 Canis lupus familiaris
529590 Bos taurus
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