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anti-Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Antibodies

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. Additionally we are shipping Sodium Channel, Voltage-Gated, Type I, beta Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN1B 20266 P97952
SCN1B 29686 Q00954
SCN1B 6324 Q07699
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Top anti-Sodium Channel, Voltage-Gated, Type I, beta Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SCN1B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB SCN1B Antibody (N-Term)  western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SCN1B antibody detected the SCN1B protein (arrow). SCN1B Antibody (N-Term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow Cytometric analysis of Hela cells using SCN1B Antibody (N-Term) Cat.-No AP53815PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SCN1B Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot with SCN1B Polyclonal Antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated WB Anti-SCN1B antibody, Western blotting All lanes: Anti SCN1B  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: HELA Whole Cell Lysate at 40ug Predicted bind size: 25KD Observed bind size: 25KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$654.50
Details
Human Rabbit Alkaline Phosphatase (AP) FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB SCN1B antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

SCN1B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sodium Channel, Voltage-Gated, Type I, beta Antibodies

  1. Human Polyclonal SCN1B Primary Antibody for EIA, FACS - ABIN954692 : Grover, Gourie-Devi, Baghel, Sharma, Bala, Gupta, Narayanasamy, Varma, Gupta, Kaur, Talwar, Kaur, Giddaluru, Sharma, Brahmachari, Indian Genome Variation Consortium, Kukreti: Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment. in Pharmacogenomics 2010 (PubMed)
    Show all 5 references for ABIN954692

  2. Cow (Bovine) Polyclonal SCN1B Primary Antibody for WB - ABIN2776124 : Selmer, Egeland, Solaas, Nakken, Kjeldsen, Friis, Brandal, Corey, Undlien: Genetic screening of Scandinavian families with febrile seizures and epilepsy or GEFS+. in Acta neurologica Scandinavica 2008 (PubMed)

More Antibodies against Sodium Channel, Voltage-Gated, Type I, beta Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) interaction partners

  1. Loss of Scn1b caused increased amplitude of tetrodotoxin-sensitive INa (show INA Antibodies), delayed after-depolarizations, triggered beats, changed Ca2 (show CA2 Antibodies)+ transients,and susceptibility ventricular arrhythmias.

  2. Study showed that Scn1b is widely expressed at axon initial segments across the mouse brain, there is considerable heterogeneity in the proportion of Scn1b-positive neurons and the amount of expression between and within brain regions

  3. Scn1b mutant subicular and layer 2/3 pyramidal neurons had increased action potential firing rates, presumably as a consequence of their increased input resistance

  4. Stronger expressions of SCN5a (show SCN5A Antibodies), SCN1b and Kir2.1 (show KCNJ2 Antibodies) were observed in ventricular-like and atrial-like cells compared to that of pacemaker-like cardiomyocytes.

  5. Scn1b is critical for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brain development.

  6. The results presented here identify Navbeta1 as a component of native neuronal Kv4.2 (show KCND2 Antibodies)-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability.

  7. Scn1b regulates the electrical excitability of nociceptive DRG neurons in vivo by modulating both I(Na) and I(K).

  8. propose reciprocity of function between Scn1b (beta1) and Na(v)1.6 such that beta1-mediated neurite outgrowth requires Na(v)1.6-mediated I(Na), and Na(v)1.6 localization and consequent high-frequency firing require beta1

  9. The primary sodium channels present in ventricular myocytes are composed of Na(v)1.5 plus beta2 and/or beta4 subunits in intercalated disks and Na(v)1.1, Na(v)1.3 (show SCN3A Antibodies), and Na(v)1.6 plus beta1 and/or beta3 subunits in the transverse tubules.

  10. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b.

Human Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) interaction partners

  1. Contribution of Cardiac Sodium Channel (show SCN5A Antibodies) beta-Subunit (show POLG Antibodies) Variants to Brugada Syndrome.

  2. SCN1B gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.

  3. In a nonreferred nationwide Danish cohort of SIDS (show IDS Antibodies) cases, up to 5/66 (7.5%) of SIDS (show IDS Antibodies) cases can be explained by genetic variants in the sodium channel complex genes.

  4. We also identified an SCN1B T189M variant in 2 probands with lone AF and in 1 of 250 control subjects.

  5. Study showed that the human SCN1B C121W epilepsy mutation leads to decreased axon initial segments expression of SCN1B in heterozygous CW mice and a complete lack of SCN1B in homozygous WW mice

  6. High SCN1B expression is associated with increased tumour growth and metastasis in breast cancer.

  7. experimental data indicate that sodium channel voltage-gated type I beta subunit (Navbeta1b)/H162P results in reduced sodium channel activity functionally affecting the ventricular action potential.

  8. SCN1B mutation is not a common cause of Dravet syndrome.

  9. results suggest that R214Q variation in SCN1Bb is a functional polymorphism that may serve as a modifier of the substrate responsible for Brugada syndrome or SIDS (show IDS Antibodies) phenotypes

  10. Mutation analysis of the SCN1B, SCN1A (show SCN1A Antibodies) and GABRG2 (show GABRG2 Antibodies) genes in children affected by Genetic (Generalised) Epilepsy with Febrile Seizures plus was performed

Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Antigen Profile

Protein Summary

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SCN1B

  • sodium channel, voltage-gated, type I, beta (Scn1b) antibody
  • sodium channel, voltage-gated, type I, beta subunit (SCN1B) antibody
  • GEFSP1 antibody

Protein level used designations for SCN1B

sodium channel subunit beta-1 , sodium channel, voltage-gated, type I, beta polypeptide , sodium channel voltage-gated type 1 beta polypeptide , sodium channel voltage-gated type I beta polypeptide , sodium channel, voltage-gated, type 1, beta polypeptide , sodium channel beta-1 subunit , sodium channel beta 1-subunit

GENE ID SPECIES
20266 Mus musculus
29686 Rattus norvegicus
6324 Homo sapiens
484584 Canis lupus familiaris
618204 Bos taurus
100009211 Oryctolagus cuniculus
747705 Pan troglodytes
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