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Sodium Channel, Voltage-Gated, Type II, alpha Subunit Proteins (SCN2A)

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. Additionally we are shipping SCN2A Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse SCN2A SCN2A 110876  
Rat SCN2A SCN2A 24766 P04775
SCN2A 6326 Q99250
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Top SCN2A Proteins at antibodies-online.com

Showing 2 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SCN2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A) Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A) interaction partners

  1. Inhibitory postsynaptic currents in NaV1.2 adult neurons were larger and the expression level of Scn2a mRNA was lower compared with the wild-type.

  2. Reducing of NaV1.2-mediated currents in interneurons promoted recurrent network activity.

  3. interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.

  4. Nav1.2 expression levels are elevated in the brain of sodium channel blocker-treated animamls with experimental autoimmune encephalomyelitis.

  5. The present findings show a polarised distribution of Na(v)1.2 along the neuronal surface of granule cells and suggest its primary involvement in the transmission of information from granule cells to Purkinje cells.

  6. Immunohistochemical stainings of mouse cerebellum with a NaV1.2-specific antibody revealed a prominent increase in staining of the molecular layer during postnatal development.

  7. However, Na(v)1.2 channels show a greater accumulation of inactivation at higher frequencies of stimulation (20-100 Hz) than Na(v)1.6 and thus are likely to generate lower frequencies of firing.

  8. Genetic modifiers affect the severity of epilepsy caused by mutation of sodium channel Scn2a.

  9. The data support the hypothesis that modified Scn2a channels in Q54 mice result in network hyperexcitability of the hippocampus necessary for the development and maintenance of temporal lobe seizures.

  10. The results are consistent with a model in which Na(v)1.6 and Na(v)1.2 compete for binding partners at sites of high channel density

Human Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A) interaction partners

  1. We argue that very rare, loss-of-function mutations at SCN2A act in a moderately penetrant manner to increase the risk of developing several neuropsychiatric disorders including seizure disorders, intellectual disability, autism and schizophrenia.

  2. Mutations in SCN1A (show SCN1A Proteins) and SCN2A are a predisposing factor of acute encephalopathy with biphasic seizures and late reduced diffusion

  3. Findings provide convergent evidence that a common polymorphism in SCN2A accounts for significant interindividual variability in human general cognitive ability, possibly by modulating prefrontal cortex physiology

  4. This study provide the evidence SCN2A mutation releate to Autism Spectrum Disorder.

  5. A heterozygous mutation (c.3631G > A; p.E1211K) was identified in exon 21 of SCN2A gene. This is the first case of SCN2A mutation identified in Chinese.

  6. Case suggests that SCN2A mutations might predispose children to repetitive encephalopathy with variable clinical and imaging findings.

  7. SCN2A is the second most common cause of epilepsy of infancy with migrating focal seizures

  8. Two lysine residues (residues 105-106)of AnkG are critical for Nav1.2 but not KCNQ3 channel binding.

  9. Epileptic encephalopathy related to mutations in the SCN2A genes.

  10. the mechanism of AED resistance remains uncertain, which led us to evaluate the impact of polymorphisms of the SCN1A, SCN2A and ABCC2 genes on the AED response in Chinese Han patients with epilepsy in the present study.

SCN2A Protein Profile

Protein Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with SCN2A

  • sodium channel, voltage-gated, type II, alpha subunit (SCN2A)
  • sodium channel, voltage-gated, type II, alpha subunit (LOC100217927)
  • sodium channel, voltage-gated, type II, alpha 1 (Scn2a1)
  • 6430408L10 protein
  • A230052E19Rik protein
  • BFIC3 protein
  • BFIS3 protein
  • BFNIS protein
  • EIEE11 protein
  • HBA protein
  • HBSCI protein
  • HBSCII protein
  • Na(v)1.2 protein
  • NAC2 protein
  • NachII protein
  • Nav1.2 protein
  • RII/RIIA protein
  • RNSCPIIR protein
  • SCN protein
  • SCN2A protein
  • SCN2A1 protein
  • Scn2a2 protein
  • ScpII protein

Protein level used designations for SCN2A

sodium channel, voltage-gated, type II, alpha subunit , sodium channel protein type 2 subunit alpha-like , sodium channel, voltage-gated, type II, alpha polypeptide 1 , RIIA sodium channel protein , alternative product , sodium channel protein brain II subunit alpha , sodium channel protein type 2 subunit alpha , sodium channel protein type II subunit alpha , sodium channel protein, brain II subunit alpha , sodium channel voltage-gated type II alpha polypeptide , sodium channel, voltage-gated, type 2, alpha 1 polypeptide , sodium channel, voltage-gated, type 2, alpha 1 subunit , voltage-gated sodium channel subunit alpha Nav1.2 , HBSC II , sodium channel protein, brain type 2 alpha subunit , sodium channel, voltage-gated, type II, alpha 1 polypeptide , sodium channel, voltage-gated, type II, alpha 2 polypeptide , voltage-gated sodium channel subtype II , voltage-gated sodium channel II , sodium channel protein , sodium channel, type II, alpha polypeptide , sodium channel, voltage-gated, type II, alpha 1

GENE ID SPECIES
459700 Pan troglodytes
703298 Macaca mulatta
100016409 Monodelphis domestica
100051816 Equus caballus
100217927 Taeniopygia guttata
100389294 Callithrix jacchus
100484218 Ailuropoda melanoleuca
110876 Mus musculus
24766 Rattus norvegicus
6326 Homo sapiens
395945 Gallus gallus
478773 Canis lupus familiaris
396588 Sus scrofa
539718 Bos taurus
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