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anti-Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A) Antibodies

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. Additionally we are shipping SCN4A Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN4A 110880 Q9ER60
SCN4A 6329 P35499
SCN4A 25722 P15390
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Top anti-SCN4A Antibodies at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of Nav1.4 expression in MCF7 (A), NIH3T3 (B), H9C2 (C), mouse brain (D) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB   0.2 mL Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$375.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 8 to 10 Days
$551.83
Details

SCN4A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Human


Rat (Rattus)


Top referenced anti-SCN4A Antibodies

  1. Human Polyclonal SCN4A Primary Antibody for IHC, WB - ABIN350854 : George, Komisarof, Kallen, Barchi: Primary structure of the adult human skeletal muscle voltage-dependent sodium channel. in Annals of neurology 1992 (PubMed)
    Show all 5 references for ABIN350854

  2. Human Polyclonal SCN4A Primary Antibody for EIA, IHC (fro) - ABIN1108950 : Gershome, Lin, Kashihara, Hove-Madsen, Tibbits: Colocalization of voltage-gated Na+ channels with the Na+/Ca2+ exchanger in rabbit cardiomyocytes during development. in American journal of physiology. Heart and circulatory physiology 2011 (PubMed)

More Antibodies against SCN4A Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A) interaction partners

  1. In-depth characterization of draggen mice uncovered novel systemic metabolic abnormalities in Scn4a mouse models and provided novel insights into disease mechanisms

  2. HyperKPP phenotype does not depend solely on the NaV1.4 content.

  3. A distinct autosomal recessive myotonic mouse in the C57BL/6 background (line B6MT)is reported in which the Scn4a gene shows polymorphism with no functional consequences.

  4. The skeletal muscle isoform of Na(v)1.4, which represents over 90% of voltage-gated sodium channels in muscle, plays an important role in development of abnormally high Na(+) concentrations found in muscle from mdx (show DMD Antibodies) mice.

Human Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A) interaction partners

  1. association of the genetic variability of SCN4A with the development of essential tremor

  2. Computer simulations of the effects of the I693T mutation were introduced in the muscle fiber model by both hyperpolarizing shifts in the Nav1.4 channel activation and a faster recovery from slow channel inactivation

  3. CACNA1S (show CACNA1S Antibodies) and SCN4A mutations are relatively rare in patients with hypokalemic periodic paralysis

  4. Recessive loss-of-function SCN4A mutations were identified in congenital myopathy patients.

  5. The c.4427 T>C (p.Met1476Thr) mutation of the SCN4A gene contribute to the paramyotonia congenita.

  6. Mutation analysis in the patient and in child's mother revealed a heterozygous p.N1180I mutation in exon 19 of SCN4A gene. In newborns with stiffness, peripheral contractures and myotonia, the sequence analysis of SCN4A gene should be performed.

  7. As the result, heterozygous mutations c.2024G>A (R675Q) and c.1333G>A (V445M) of gene SCN4A were identified in the hypokalemic periodic paralysis patient and the paramyotonia congenita family respectively.

  8. The patient with scn4a mutation exhibited various symptoms that evolved with age, including apneic episodes, tonic muscular contractions during sleep, fluctuating severe episodic myotonia, and finally episodic paralyses.

  9. Electrophysiological studies of the SCN4A P72L variant showed a hyperpolarizing shift (-5 mV) of the voltage dependence of activation that may increase cell excitability

  10. A Val1589Met mutation at exon 24 of the SCN4A gene appears in affected subjects with a mild form of paramyotonia, while healthy members had a point mutation at position 1513 at exon 24 of the SCN4A gene

SCN4A Antigen Profile

Protein Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders.

Gene names and symbols associated with SCN4A

  • sodium channel, voltage-gated, type IV, alpha subunit (SCN4A) antibody
  • sodium channel, voltage-gated, type IV, alpha (Scn4a) antibody
  • sodium channel, voltage-gated, type IV, alpha subunit (Scn4a) antibody
  • HOKPP2 antibody
  • HYKPP antibody
  • HYPP antibody
  • mH2 antibody
  • microI antibody
  • Na(V)1.4 antibody
  • NAC1A antibody
  • Nav1.4 antibody
  • NCHVS antibody
  • SkM1 antibody

Protein level used designations for SCN4A

sodium channel, voltage-gated, type IV, alpha subunit , sodium channel protein type 4 subunit alpha-like , sodium channel alpha-subunit , sodium channel protein skeletal muscle subunit alpha , sodium channel protein type 4 subunit alpha , sodium channel protein type IV subunit alpha , sodium channel, voltage-gated, type IV, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.4 , skeletal muscle voltage-dependent sodium channel type IV alpha subunit , Sodium channel voltage-gated type IV alpha polypeptide , mu-1 , skM1 , sodium channel voltage-gated type 4 alpha polypeptide , sodium channel, voltage-gated, type 4, alpha polypeptide , sodium channel, voltage-gated, type 4, alpha subunit , Sodium channel protein skeletal muscle subunit alpha , Sodium channel protein type IV subunit alpha , Voltage-gated sodium channel subunit alpha Nav1.4 , skeletal muscle sodium channel alpha-subunit

GENE ID SPECIES
610754 Canis lupus familiaris
718194 Macaca mulatta
100414137 Callithrix jacchus
100450057 Pongo abelii
100470881 Ailuropoda melanoleuca
100511715 Sus scrofa
100612017 Pan troglodytes
110880 Mus musculus
6329 Homo sapiens
25722 Rattus norvegicus
100049793 Equus caballus
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