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anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Antibodies

SCN9A encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Additionally we are shipping SCN9A Kits (13) and SCN9A Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN9A 20274  
SCN9A 78956 O08562
SCN9A 6335 Q15858
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Top anti-SCN9A Antibodies at antibodies-online.com

Showing 10 out of 96 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Hamster Mouse Un-conjugated ICC, IF, IP, WB Nav1.7 (S68-6) in T-CHO Nav1.7 (S68-6), Mouse brain tissue, Amplifier 100 μg Log in to see 3 to 4 Days
$383.90
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SCN9A Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ICC, IP, WB 100 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of Nav1.7 expression in MCF7 (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-SCN9A / Nav1.7 antibody  ABIN1049323 IHC staining of human small intestine, neuroendocrine cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated IF, IP, WB   0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Hamster Mouse HRP ICC, IF, IP, WB   100 μg Log in to see 3 to 4 Days
$422.40
Details
Hamster Mouse FITC ICC, IF, IP, WB   100 μg Log in to see 3 to 4 Days
$426.80
Details
Hamster Mouse Alkaline Phosphatase (AP) ICC, IF, IP, WB   100 μg Log in to see 3 to 4 Days
$429.00
Details

SCN9A Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SCN9A Antibodies

  1. Hamster Monoclonal SCN9A Primary Antibody for ICC, IF - ABIN361773 : Dray: Neuropathic pain: emerging treatments. in British journal of anaesthesia 2008 (PubMed)
    Show all 4 references for ABIN361773

  2. Human Polyclonal SCN9A Primary Antibody for IHC, ELISA - ABIN1535378 : Cox, Reimann, Nicholas, Thornton, Roberts, Springell, Karbani, Jafri, Mannan, Raashid, Al-Gazali, Hamamy, Valente, Gorman, Williams, McHale, Wood, Gribble, Woods: An SCN9A channelopathy causes congenital inability to experience pain. in Nature 2006 (PubMed)

More Antibodies against SCN9A Interaction Partners

Cow (Bovine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. TNF-alpha (show TNF Antibodies) up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha (show TNF Antibodies)

  2. Findings suggest that the endothelin-1 (show EDN1 Antibodies)-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau.

  3. Nav1.7-Ca2 (show CA2 Antibodies)+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK (show MAPK1 Antibodies)) and p38 (show MAPK14 Antibodies) attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK (show MAPK1 Antibodies) and p38 (show MAPK14 Antibodies)

  4. constitutively phosphorylated/activated ERK (show MAPK1 Antibodies) destabilizes Na(+) channel alpha-subunit (show POLG Antibodies) mRNA via translational event, which negatively regulates steady-state level of alpha-subunit (show POLG Antibodies) mRNA and cell surface expression of functional Na(+) channels.

  5. Na influx via scn9a converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (show PENK Antibodies) mRNA and met-enkephalin protein in sensory neurons.

  2. Global Nav1.7 knockouts showed no defects in mechanical sensitivity or overall movement yet were completely insensitive to painful tactile, thermal, and chemical stimuli and were anosmic.

  3. Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability.

  4. a novel regulatory mechanism that utilizes CRMP2 (show DPYSL2 Antibodies) SUMOylation to choreograph NaV1.7 trafficking.

  5. Behavioural deficits in Nav1.7/Nav1.8 (show SCN10A Antibodies) knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents.

  6. Deleting SCN9A in both sensory and sympathetic neurons abolishes pain sensations.

  7. These results demonstrate increased expression levels of Nav1.7, Nav1.8 (show SCN10A Antibodies), and perhaps Nav1.1 (show SCN1A Antibodies) in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 (show NF1 Antibodies) gene

  8. Nav1.7 is the dominant sodium channel in rat and mouse olfactory sensory neurons.

  9. examined the function of Na(v)1.7 (PN1) in pain pathways [Na(v)1.7]

  10. contrast to the highly significant role for Nav1.7 in determining inflammatory pain thresholds, the development of neuropathic pain does not require the presence of either Nav1.7 or Nav1.8 (show SCN10A Antibodies) alone or in combination

Human Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. Postoperative pain was affected by SCN9A genetic variability in gynecological surgical patients.

  2. Patients with the SCN9A mutation with inherited erythromelalgia were characterized for the pain phenotype among individuals.

  3. These findings provided evidence that the variability of basal pain sensitivity was associated with SCN9A polymorphisms in the general population.

  4. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (show PENK Antibodies) mRNA and met-enkephalin protein in sensory neurons.

  5. Association of SCN9A variants with neuropathic pain and pain severity suggests a role of SCN9A in the disease etiology of neuropathic pain

  6. We report the case of a 6-year-old girl with a SCN9A mutation who presented with both gain of function and loss of function phenotypes, including congenital corneal anesthesia.

  7. the activity of mutant Nav1.7 channels in smooth muscle cells of skin vasculature and innervating sensory and sympathetic fibers contribute to the skin reddening

  8. Novel SCN9A mutations altering Nav1.7 channel activation were found families with inherited erythromelalgia, paroxysmal extreme pain disorder and congenital insensitivity to pain.

  9. NaV1.7 is expressed in both dorsal root ganglion neurons and pancreatic beta cells.Vulnerability of dorsal root ganglia neurons due to NaV1.7 mutations increases risk of neuropathy.

  10. Our study demonstrates an example of predicting the treatment effect of mexiletine in patients suffering from a specific gain-of-function mutation in NaV1.7

SCN9A Antigen Profile

Protein Summary

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.

Gene names and symbols associated with SCN9A

  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A) antibody
  • sodium channel, voltage-gated, type IX, alpha (Scn9a) antibody
  • DKFZp459G084 antibody
  • ETHA antibody
  • FEB3B antibody
  • GEFSP7 antibody
  • mKIAA4197 antibody
  • Nav1.7 antibody
  • NE-NA antibody
  • NENA antibody
  • PN1 antibody
  • Scn2a antibody
  • SCN9A antibody
  • SFNP antibody

Protein level used designations for SCN9A

sodium channel, voltage-gated, type IX, alpha subunit , sodium channel protein type 9 subunit alpha-like , peripheral sodium channel 1 , sodium channel 25 , sodium channel protein type 9 subunit alpha , sodium channel protein type IX subunit alpha , sodium channel, voltage-gated, type IX, alpha polypeptide , voltage-gated sodium channel alpha subunit Nav1.7 , voltage-gated sodium channel subunit alpha Nav1.7 , sodium channel, voltage-gated, type 9, alpha polypeptide , hNE-Na , neuroendocrine sodium channel , nas , schwann cell sodium channel , sodium channel alpha-subunit

GENE ID SPECIES
488381 Canis lupus familiaris
533065 Bos taurus
100016648 Monodelphis domestica
100172961 Pongo abelii
100385702 Callithrix jacchus
100482886 Ailuropoda melanoleuca
100516701 Sus scrofa
100583836 Nomascus leucogenys
20274 Mus musculus
78956 Rattus norvegicus
6335 Homo sapiens
100009210 Oryctolagus cuniculus
Selected quality suppliers for anti-SCN9A (SCN9A) Antibodies
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