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anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antibodies

The protein encoded by SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Additionally we are shipping Sodium Channel, Voltage-Gated, Type V, alpha Subunit Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN5A 20271 Q9JJV9
SCN5A 6331 Q14524
SCN5A 25665 P15389
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Top anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 111 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SCN5A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SCN5A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: SW620 cell lysate Host: Rabbit  Target Name: SCN5A  Sample Tissue: MCF7 Whole Cell  Lane A:  Primary Antibody Lane B: Primary Antibody + Blocking Peptide Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 5 µg/mL Lysate Quantity: 41 µg/lane/LaneGel Concentration:.12 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated ELISA, IHC, IHC (p) Western Blot: Nav1.5 Antibody [ABIN269816] - Rat Brain lysate . Immunohistochemistry-Paraffin: Nav1.5 Antibody [ABIN269816] - Mouse Brain. 0.1 mg Log in to see 5 to 7 Days
$317.63
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SCN5A  Antibody Titration: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 µg protein on gelQC Antibodies 1:100 in PBS/Tweensecondary antibodie 1:00.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey  Positive Control: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 µg protein on gelQC Antibodies 1:000 in PBS/Tweensecondary antibodie 1:00.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SCN5A Antibody (N-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-SCN5A / Nav1.5 antibody  ABIN1049322 IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

SCN5A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,
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Top referenced anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antibodies

  1. Chicken Polyclonal SCN5A Primary Antibody for WB - ABIN2776347 : Shah, Wingo, Weiss, Williams, Balser, Chazin: Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 5 references for ABIN2776347

  2. Cow (Bovine) Polyclonal SCN5A Primary Antibody for WB - ABIN2776088 : Van Norstrand, Tester, Ackerman: Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome. in Heart rhythm : the official journal of the Heart Rhythm Society 2008 (PubMed)
    Show all 2 references for ABIN2776088

  3. Human Polyclonal SCN5A Primary Antibody for ELISA, WB - ABIN185467 : Olson, Michels, Ballew, Reyna, Karst, Herron, Horton, Rodeheffer, Anderson: Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. in JAMA 2005 (PubMed)

More Antibodies against Sodium Channel, Voltage-Gated, Type V, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. Enhanced A-V conduction in mice overexpressing SCN5A in the heart mimics the human syndrome of Enhanced Atrioventricular Nodal Conduction .

  2. Loss of the C-terminus of connexin43 (show GJA1 Antibodies) limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

  3. Ser571-mediated increases in INa (show INA Antibodies),L promote abnormal repolarization and intracellular Ca(2 (show CA2 Antibodies)+) handling and increase susceptibility to arrhythmia. Ser571 is required for maladaptive remodeling and arrhythmias in response to pressure overload.

  4. intracellular Ca(2 (show CA2 Antibodies)+) contributes to the regulation of INaL conducted by NaV1.5 mutants and propose that, during excitation-contraction coupling, elevated intracellular Ca(2 (show CA2 Antibodies)+) suppresses mutant channel INaL and protects cells from delayed repolarization.

  5. Results show that Nav1.5 upregulation correlates with disease severity in monophasic and chronic-relapsing experimental autoimmune encephalomyelitis and that Nav1.5 expression in astrocytes is modulated in parallel with periods of disease and remission

  6. FoxO1 (show FOXO1 Antibodies) is involved in the modulation of NaV1.5 expression in ischemic heart disease.

  7. Our results suggested that the main expression subtype of sodium channels was Nav1.5 of early embryonic cardiomyocytes.

  8. Data indicate that reduction in connexin43 (Cx43 (show GJA1 Antibodies)) and sodium channel NaV1.5 expression coincided with overexpression of transgene calcineurin A (CnA (show CAN Antibodies)) and hypertrophy development and preceded significant presence of fibrosis.

  9. Expression of NaV1.5 in cardiomyocytes is regulated by the PDZ domain (show INADL Antibodies)-binding motif.

  10. Analysis of BAC transgenic strains harboring an engineered deletion of the enhancer within Scn10a (show SCN10A Antibodies) revealed that the enhancer was essential for Scn5a expression in cardiac tissue. SCN10A (show SCN10A Antibodies) variant rs6801957 modulated Scn5a expression in the heart.

Human Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. Molecular and pharmacological characterization of the SCN5A p.I141V mutation provide new evidence supporting the association of this mutation with exercise-induced polymorphic ventricular arrhythmias. These data also demonstrate that flecainide may serve as an effective treatment for the defect in Nav 1.5 that leads to an increased sodium window current.

  2. Compound heterozygous variants c.101G>A and c.3832G>A in the SCN5A gene were found in the complete heart block affected child and were not found in unaffected family members.

  3. the mutantinduced changes contributed to the loss of function of Nav1.5 channels, which indicates that the p.D1690N variant may have a pathogenic role in Brugada syndrome.

  4. This initial functional study for SCN5A mutation in the Chinese SUNDS victim revealed that the acidosis aggravated the loss of function of mutant channel R1512W

  5. Nav1.5 N-terminal domain binding to alpha1-syntrophin (show SNTA1 Antibodies) increases membrane density of human Kir2.1 (show KCNJ2 Antibodies), Kir2.2 (show KCNJ12 Antibodies) and Nav1.5 channels

  6. p.Gln1507-Lys1508-Pro1509del mutation, p.Arg222Ter nonsense mutation, and p.Met1498Arg mutation in the SCN5A gene in long-QT syndrome type 3, Brugada syndrome, and sick sinus syndrome, respectively, were found in the Iranian population.

  7. We investigated the frequency of the p.R1193Q substitution in > 4000 genomic DNA samples from 34 Asian, European, and African populations using TaqMan and/or APLP (show APLP1 Antibodies) (amplified product length polymorphism) assays. Allele A (p.1193Q) was detected in most Asian populations, but was sporadically observed or absent in European and African populations. These results demonstrated that the p.R1193Q substitution is character

  8. The present study demonstrated that a novel heterozygous missense mutation of A1055G in SCN5A led to 'loss-of function' of the sodium channels, and we suggest that it accounts for the arrhythmogenic characteristics of ERS.

  9. Identifies alphaB-crystallin (show CRYAB Antibodies) as a new binding partner for Nav1.5. alphaB-Crystallin (show CRYAB Antibodies) interacts with Nav1.5 and increases INa (show INA Antibodies) by modulating the expression level and internalization of cell surface Nav1.5 and ubiquitination of Nav1.5, which requires the protein-protein interactions between alphaB-crystallin (show CRYAB Antibodies) and Nav1.5 and between alphaB-crystallin (show CRYAB Antibodies) and functionally active Nedd4-2 (show NEDD4L Antibodies).

  10. The p.R1309H homozygous NaV1.5 mutation conferred both gain-of-function and loss-of-function effects on NaV1.5 channel activity. Reduction of a mutation-induced gating pore current by lidocaine suggested a therapeutic mechanism

Rabbit Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. Freshly dispersed rabbit airway smooth muscle cells express a fast voltage-gated Na(+) current that is mediated mainly by the NaV1.5 subtype.

  2. Mechanisms are determined by a two-dimensional slice model at single-cell and tissue levels in order to determine that SCN5A mutations impair cardiac pacemaking.

Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antigen Profile

Protein Summary

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.

Gene names and symbols associated with SCN5A

  • sodium channel, voltage-gated, type V, alpha subunit (SCN5A) antibody
  • sodium channel, voltage-gated, type V, alpha (Scn5a) antibody
  • sodium channel, voltage-gated, type V, alpha subunit (Scn5a) antibody
  • CDCD2 antibody
  • CMD1E antibody
  • CMPD2 antibody
  • HB1 antibody
  • HB2 antibody
  • HBBD antibody
  • HH1 antibody
  • ICCD antibody
  • IVF antibody
  • LQT3 antibody
  • mH1 antibody
  • Nav1.5 antibody
  • Nav1.5c antibody
  • PFHB1 antibody
  • SCAL antibody
  • SkM1 antibody
  • SkM2 antibody
  • SSS1 antibody
  • VF1 antibody

Protein level used designations for SCN5A

sodium channel, voltage-gated, type V, alpha subunit , voltage-gated sodium channel type V alpha , sodium channel protein type 5 subunit alpha , voltage-gated sodium channel cardiac isoform Nav1.5 , sodium channel protein cardiac muscle subunit alpha , sodium channel protein type V subunit alpha , sodium channel voltage-gated type V alpha polypeptide , sodium channel, voltage-gated, type V, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.5 , cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit , cardiac sodium channel , sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) , voltage-gated sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha polypeptide (long (electrocardiographic) QT syndrome 3) , sodium channel, voltage-gated, type 5, alpha subunit , voltage-gated sodium channel Nav1.5c , oltage-gated sodium channel type V alpha , voltage-dependent sodium channel SCN10A , voltage-gated sodium channel H , voltage-gated sodium channel type V alpha polypeptide

GENE ID SPECIES
747523 Pan troglodytes
100034027 Equus caballus
20271 Mus musculus
6331 Homo sapiens
403497 Canis lupus familiaris
282061 Bos taurus
25665 Rattus norvegicus
395947 Gallus gallus
100009516 Oryctolagus cuniculus
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