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anti-Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) Antibodies

SCN8A encodes a member of the sodium channel alpha subunit gene family. Additionally we are shipping SCN8A Proteins (11) and SCN8A Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN8A 6334 Q9UQD0
SCN8A 29710 O88420
SCN8A 20273 Q9WTU3
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Top anti-SCN8A Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SCN8A on NIH/3T3 cell (antibody concentration 10 µg/mL). SCN8A monoclonal antibody (M04), clone 4G7 Western Blot analysis of SCN8A expression in NIH/3T3. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to SCN8A on NIH/3T3 cell. [antibody concentration 10 ug/ml] SCN8A monoclonal antibody (M04), clone 4G7 Western Blot analysis of SCN8A expression in NIH/3T3 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Nav1.6 expression in MCF7 (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Cow Rabbit Un-conjugated WB Western blot analysis of Nav1.6 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated IF, WB 0.1 mg Log in to see 3 to 4 Days
$601.76
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated WB SCN8A antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

SCN8A Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SCN8A Antibodies

  1. Human Polyclonal SCN8A Primary Antibody for IHC, WB - ABIN350857 : De Repentigny, Cuotue, Pool, Bernier, Girard, Vidal, Kothary: Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a. in Human molecular genetics 2001 (PubMed)
    Show all 5 references for ABIN350857

  2. Human Polyclonal SCN8A Primary Antibody for IHC, WB - ABIN350858 : Fotia, Ekberg, Adams, Cook, Poronnik, Kumar: Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN350858

  3. Human Monoclonal SCN8A Primary Antibody for IF, WB - ABIN396453 : Wang, Zhang, Liu, Shao, Wei, Li, Ji, Yang, Wang, Liu, Wan, Li, Xu, Feng, He, He: Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population. in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2010 (PubMed)
    Show all 5 references for ABIN396453

  4. Human Monoclonal SCN8A Primary Antibody for IF, WB - ABIN2476430 : Ogiwara, Miyamoto, Morita, Atapour, Mazaki, Inoue, Takeuchi, Itohara, Yanagawa, Obata, Furuichi, Hensch, Yamakawa: Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  5. Dog (Canine) Polyclonal SCN8A Primary Antibody for WB - ABIN2776199 : Martin, Tang, Papale, Yu, Catterall, Escayg: The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy. in Human molecular genetics 2007 (PubMed)

More Antibodies against SCN8A Interaction Partners

Human Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) interaction partners

  1. Either the FGF14 (show FGF14 Antibodies)(V160A) or the FGF14 (show FGF14 Antibodies)(K74A/I76A) mutation was sufficient to abolish the FGF14 (show FGF14 Antibodies)-dependent regulation of peak transient Na(+) currents and the voltage-dependent activation and steady-state inactivation of Nav1.6; but only V160A with a concomitant alanine mutation at Tyr (show TYR Antibodies)-158 could impede FGF14 (show FGF14 Antibodies)-dependent modulation of the channel fast inactivation.

  2. we report an infant and his father with early onset focal epileptic seizures but without cognitive or neurological impairment in whom next generation sequence analysis identified a heterozygous mutation (c.5630A > G, p. (Asn1877Ser)) in the SCN8A gene

  3. the calpain-dependent cleavage of Nav1.6 channels expressed in human embryonic kidney (HEK) 293 cells caused the upregulation of I(NaP)

  4. Our study establishes SCN8A as a novel gene in which a recurrent mutation causes BFIS/ICCA (show PRRT2 Antibodies), expanding the clinical-genetic spectrum of combined epileptic and dyskinetic syndromes.

  5. Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 (show SCN1A Antibodies) channels, but the SCN4B (show SCN4B Antibodies)-derived Navbeta4 (show SCN4B Antibodies) peptide does not protect either isoform from use-dependent reduction.

  6. These data strengthen previous findings linking gain-of-function mutations of SCN8A with EIEE and demonstrate the importance of functional testing in establishing the pathogenicity of de novo mutations.

  7. Expression profiling of SCN8A and NDUFC2 (show NDUFC2 Antibodies) genes in colorectal carcinoma is reported. There was no NDUFC2 (show NDUFC2 Antibodies) differential expression in colorectal carcinoma.

  8. Epileptic encephalopathy related to mutations in the SCN8A genes.

  9. SCN8A encephalopathy presents in infancy with multiple seizure types.

  10. The results of this study suggested that SCN8A mutation cause early onset epilepsy and intellectual disability.

Mouse (Murine) Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) interaction partners

  1. The clinical phenotype of the severe hypomorphic sodium channel gene SCN8A mutant expands the spectrum of Scn8a disease to include a recessively inherited, chronic and progressive movement disorder.

  2. the presences of Nav1.1 (show SCN1A Antibodies), Nav1.6, Navbeta1 and Navbeta3 mRNA and their reduced levels in rat SAN during aging.

  3. This study demonstrates that Nav channel expression in lumbar motoneurons is altered after SCI, and it shows a tight relationship between the calpain-dependent proteolysis of Nav1.6 channels, the upregulation of I(NaP (show CTNNBL1 Antibodies)) and spastici

  4. the role of Nav1.6 in general anesthesia using two mouse mutants with reduced activity of Nav1.6, was examined.

  5. observed increased hippocampal pyramidal cell excitability in heterozygous and homozygous Scn8a-R1627H mutants, and decreased interneuron excitability in heterozygous Scn8a-R1627H mutants.

  6. The data support a model where ankyrinG (show ANK3 Antibodies)-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development.

  7. the degenerating muscle mutation is a loss of function mutation of scn8a

  8. N1768D mutation of SCN8A is sufficient to induce seizures and SUDEP in knock-in mice.

  9. APP (show APP Antibodies) enhances Nav1.6 sodium channel cell surface expression through a Go-coupled JNK (show MAPK8 Antibodies) pathway

  10. This study provided evidence for a direct link between sodium channel activity and modulation of Rac1 and ERK1/2 (show MAPK1/3 Antibodies) activation in ATP-stimulated microglia, possibly by regulating Ca(2 (show CA2 Antibodies)+) transients

SCN8A Antigen Profile

Protein Summary

This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with SCN8A

  • sodium channel, voltage gated, type VIII, alpha subunit (SCN8A) antibody
  • sodium channel, voltage gated, type VIII, alpha subunit (Scn8a) antibody
  • sodium channel, voltage-gated, type VIII, alpha (Scn8a) antibody
  • AI853486 antibody
  • C630029C19Rik antibody
  • CERIII antibody
  • CIAT antibody
  • dmu antibody
  • EIEE13 antibody
  • med antibody
  • mnd-2 antibody
  • mnd2 antibody
  • NaCh6 antibody
  • Nav1.6 antibody
  • nmf2 antibody
  • nmf58 antibody
  • nmf335 antibody
  • nur14 antibody
  • PN4 antibody
  • seal antibody

Protein level used designations for SCN8A

hNa6/Scn8a voltage-gated sodium channel , sodium channel protein type 8 subunit alpha , voltage-gated sodium channel subunit alpha Nav1.6 , Na+ channel , PN4 , naCh6 , peripheral nerve protein type 4 , sodium channel 6 , sodium channel protein type VIII subunit alpha , sodium channel voltage-gated type VIII alpha polypeptide , sodium channel, voltage-gated, type 8, alpha polypeptide , sodium channel, voltage-gated, type 8, alpha subunit , sodium channel, voltage-gated, type VIII, alpha polypeptide , ataxia 3

GENE ID SPECIES
6334 Homo sapiens
477604 Canis lupus familiaris
29710 Rattus norvegicus
537277 Bos taurus
20273 Mus musculus
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