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anti-Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) Antibodies

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Additionally we are shipping Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN11A 24046 Q9R053
SCN11A 29701 O88457
SCN11A 11280 Q9UI33
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Top anti-Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Antibodies at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged SCN11A is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (33 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Mouse Rabbit Un-conjugated IHC   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IP, WB   200 μg Log in to see 8 to 10 Days
$881.83
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB   0.2 mL Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry of Human breast cancer using SCN11A Polyclonal Antibody at dilution of 1:40 200 μL Log in to see 8 to 9 Days
$588.50
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 8 to 10 Days
$551.83
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details

SCN11A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , ,


Rat (Rattus) ,


Human ,
,
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Top referenced anti-Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Antibodies

  1. Human Monoclonal SCN11A Primary Antibody for ELISA, WB - ABIN394475 : Catterall, Goldin, Waxman: International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. in Pharmacological reviews 2005 (PubMed)
    Show all 5 references for ABIN394475

  2. Human Polyclonal SCN11A Primary Antibody for IHC, WB - ABIN350851 : Blum, Kafitz, Konnerth: Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. in Nature 2002 (PubMed)
    Show all 5 references for ABIN350851

  3. Mouse (Murine) Polyclonal SCN11A Primary Antibody for IHC - ABIN350852 : Benn, Costigan, Tate, Fitzgerald, Woolf: Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 (PubMed)
    Show all 4 references for ABIN350852

More Antibodies against Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) interaction partners

  1. A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain.

  2. We conclude that Nav1.9 acts as a subthreshold amplifier in cold-sensitive nociceptive neurons and is required for the perception of cold pain under normal and pathological conditions.

  3. NaV1.9 is required for persistence of responses to intense mechanical stimulation, contributes to inflammatory mechanical hypersensitivity, and is essential for activation by noxious inflammatory mediators, including those from diseased human bowel.

  4. The results strongly suggested that Nav1.9 was expressed and functionally contributed to the signaling processing in the central auditory pathway.

  5. Axon growth of NaV1.9-deficient motoneurons in cell culture is drastically reduce.

  6. In the stable NaV1.9-deficient cells we successfully constructed, proliferation, phagocytosis and migration were obviously inhibited.

  7. Na(V)1.9 function appears to be essential for activity-dependent axon growth in motor neurons, acting upstream of spontaneous Ca(2 (show CA2 Antibodies)+) elevation through voltage-gated calcium channels.

  8. Results provide evidence that Nav1.9 plays a crucial role in the generation of heat and mechanical pain hypersensitivity, both in subacute and chronic inflammatory pain models.

  9. results indicate that the spontaneous augmentation of Na(V)1.9 was regulated directly by protein kinase A, and indirectly by protein kinase C (show PKC Antibodies)

  10. inflammatory mediators modify the function of NaV1.9 to maintain inflammation-induced hyperalgesia

Human Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) interaction partners

  1. A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain.

  2. A G699R substitution in the Nav1.9 domain II S4-S5 linker renders dorsal root ganglion neurons hyperexcitable, via depolarized resting membrane potential, reduced current threshold and increased evoked firing in small-fiber neuropathy.

  3. missense mutations of Nav1.9 in individuals with painful peripheral neuropathy

  4. The results demonstrate that Nav1.8 (show SCN10A Antibodies) and Nav1.9 are present in human lingual nerve neuromas, with significant correlations between the level of expression of Nav1.8 (show SCN10A Antibodies) and symptoms of pain.

  5. we identified a specific de novo missense mutation in SCN11A in individuals with the congenital inability to experience pain who suffer from recurrent tissue damage and severe mutilations.

  6. Gain-of-function mutations in SCN11A can be causative of an autosomal-dominant episodic pain disorder.

  7. Results provide evidence that Nav1.9 plays a crucial role in the generation of heat and mechanical pain hypersensitivity, both in subacute and chronic inflammatory pain models.

  8. we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin (show BDNF Antibodies)-evoked excitation

Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) Antigen Profile

Protein Summary

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity).

Gene names and symbols associated with SCN11A

  • sodium channel, voltage-gated, type XI, alpha subunit (SCN11A) antibody
  • sodium channel, voltage-gated, type XI, alpha (Scn11a) antibody
  • sodium channel, voltage-gated, type XI, alpha subunit (Scn11a) antibody
  • NaN antibody
  • NaT antibody
  • NAV1.9 antibody
  • NSS2 antibody
  • SCN11A antibody
  • SCN12A antibody
  • SNS-2 antibody
  • SNS2 antibody

Protein level used designations for SCN11A

sodium channel, voltage-gated, type XI, alpha subunit , sodium channel protein type 11 subunit alpha-like , sensory neuron sodium channel 2 , sodium channel protein type 11 subunit alpha , sodium channel protein type XI subunit alpha , sodium channel, voltage-gated, type XI, alpha polypeptide , voltage-gated sodium channel NAV1.9b , voltage-gated sodium channel subunit alpha Nav1.9 , sodium channel voltage-gated type 11 alpha polypeptide , sodium channel voltage-gated type XI alpha polypeptide , sodium channel, voltage-gated, type 11, alpha polypeptide , sodium channel, voltage-gated, type11, alpha polypeptide , PN5 , hNaN , peripheral nerve sodium channel 5 , sodium channel, voltage-gated, type XII, alpha polypeptide , voltage-gated sodium channel Nav1.9

GENE ID SPECIES
460275 Pan troglodytes
100349709 Oryctolagus cuniculus
100414951 Callithrix jacchus
100464374 Ailuropoda melanoleuca
100601668 Nomascus leucogenys
24046 Mus musculus
29701 Rattus norvegicus
11280 Homo sapiens
485593 Canis lupus familiaris
100739142 Sus scrofa
535956 Bos taurus
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