Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) ELISA Kits

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Additionally we are shipping Sodium Channel, Voltage-Gated, Type I, alpha Subunit Antibodies (24) and Sodium Channel, Voltage-Gated, Type I, alpha Subunit Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SCN1A SCN1A 20265  
Anti-Rat SCN1A SCN1A 81574 P04774
Anti-Human SCN1A SCN1A 6323 P35498
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More ELISA Kits for Sodium Channel, Voltage-Gated, Type I, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 (show GABRA2 ELISA Kits) receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a+/- mice. These findings support Gabra2 (show GABRA2 ELISA Kits) as a genetic modifier of the Scn1a+/- mouse model of Dravet syndrome.

  2. In this study, we characterized the behavior of heterozygous mice expressing the SCN1A R1648H mutation (Scn1a(RH/+)) and the effect of stress on spontaneous and induced seizures. We also examined the effect of the R1648H mutation on the hypothalamic-pituitary-adrenal (HPA (show HPSE ELISA Kits)) axis response.

  3. findings establish an unexpected role for Nav1.1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain

  4. Deletion of Nav1.1 channels selectively impairs excitability of GABAergic interneurons

  5. Results show Nav1.1 haploinsufficiency in excitatory neurons has an ameliorating effect on the pathology of Dravet syndrome.

  6. These results establish a direct role for SCN1A in the regulation of sleep

  7. Loss of NaV1.1 channels in forebrain GABAergic neurons is both necessary and sufficient to cause epilepsy and premature death in Dravet syndrome.

  8. mice with Scn1a haploinsufficiency exhibit hyperactivity, stereotyped behaviours, social interaction deficits and impaired context-dependent spatial memory; results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome

  9. These results demonstrate increased expression levels of Nav1.7 (show SCN9A ELISA Kits), Nav1.8 (show SCN10A ELISA Kits), and perhaps Nav1.1 in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 (show NF1 ELISA Kits) gene

  10. Na(V)1.1 channels are expressed in the suprachiasmatic nucleus (SCN (show SRI ELISA Kits)) of the hypothalamus.

Human Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. This study demonstrated that early-life prolonged FSs have a profound long-term impact on neuronal function and adult seizure phenotypes in a mouse model of human SCN1A dysfunction.

  2. this study showed that SCN1A testing be considered in all individuals with febrile seizures or Dravet syndrome , as well as in familial cases consistent with febrile seizures.

  3. This study found significant differences in the distribution of truncating and missense variants across the SCN1A sequence among healthy individuals, patients with Dravet syndrome.

  4. SCN1A mutations may alter axonal function, causing motor neuropathy/neuronopathy. This may contribute to gait disturbance and orthopedic misalignment, which is characteristic of patients with Dravet syndrome.

  5. The association study indicated that age at first seizure and frameshift mutations of SCN1A were associated with Dravet syndrome.

  6. Study reported the range of rare copy number variants found in SCN1A gene in a series of Welsh patients with childhood-onset epilepsy and intellectual disability and identified clearly or likely pathogenic CNVs in 8.8 % of the patients including 5 rare de novo deletions.

  7. Our findings suggest that SCN1A mutation leads to changes in the dopamine system that may contribute to the behavioral abnormalities in DS.

  8. This study demonstrated that a significant higher frequency of the AG genotype (p=0.001) and G allele (p=0.006) of SCN1A polymorphism in epileptic patients than in controls.

  9. Dravet syndrome is associated with mutations in the sodium channel alpha1 subunit gene (SCN1A) in 70-80% of individuals.

  10. The presence of SCN1A mutations and absence of mutations in ATP1A2 (show ATP1A2 ELISA Kits) or CACNA1A (show CACNA1A ELISA Kits) suggest that the Polish patients represent FHM (show CACNA1A ELISA Kits) type 3.

Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Antigen Profile

Antigen Summary

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.

Gene names and symbols associated with SCN1A

  • sodium channel, voltage-gated, type I, alpha subunit (SCN1A) antibody
  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A) antibody
  • sodium channel, voltage-gated, type I, alpha (Scn1a) antibody
  • B230332M13 antibody
  • EIEE6 antibody
  • FEB3 antibody
  • FEB3A antibody
  • FHM3 antibody
  • GEFSP2 antibody
  • HBSCI antibody
  • NAC1 antibody
  • Nav1.1 antibody
  • SCN1 antibody
  • SCN1A antibody
  • SCN9A antibody
  • SMEI antibody

Protein level used designations for SCN1A

sodium channel, voltage-gated, type IX, alpha subunit , voltage-gated sodium channel I , sodium channel, voltage-gated, type I, alpha subunit , sodium channel protein brain I subunit alpha , sodium channel protein type 1 subunit alpha , sodium channel protein type I subunit alpha , sodium channel protein, brain I subunit alpha , sodium channel voltage-gated type I alpha polypeptide , sodium channel, voltage-gated, type 1, alpha polypeptide , sodium channel, voltage-gated, type I, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.1 , sodium channel protein, brain I alpha subunit , sodium channel voltage gated type 1 alpha subunit , sodium channel voltage-gated type I alpha

GENE ID SPECIES
100052059 Equus caballus
395946 Gallus gallus
20265 Mus musculus
81574 Rattus norvegicus
6323 Homo sapiens
478775 Canis lupus familiaris
529590 Bos taurus
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