anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antibodies

The protein encoded by SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Additionally we are shipping Sodium Channel, Voltage-Gated, Type V, alpha Subunit Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN5A 20271 Q9JJV9
SCN5A 6331 Q14524
SCN5A 25665 P15389
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Top anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SCN5A Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>SW620 cell lysate Host: Rabbit <br /> Target Name: SCN5A <br /> Sample Tissue: MCF7 Whole Cell <br /> Lane A:  Primary Antibody Lane B: Primary Antibody + Blocking Peptide <br />Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 5 µg/mL Lysate Quantity: 41 µg/lane/LaneGel Concentration:.12 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-SCN5A Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Rabbit Anti-SCN5A Antibody  Catalog Number: ARP34935_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult heart  Observed Staining: Membrane (stronger than with ARP34934) Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 – 2.0 sec Protocol located in Reviews and Data. WB Suggested Anti-SCN5A Antibody Titration: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 ug protein on gelQC Antibodies 1:100 in PBS/Tweensecondary antibodie 1:10.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey Positive Control: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 ug protein on gelQC Antibodies 1:100 in PBS/Tweensecondary antibodie 1:10.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated ELISA, IHC, IHC (p) Western Blot: Nav1.5 Antibody [ABIN269816] - Rat Brain lysate . Immunohistochemistry-Paraffin: Nav1.5 Antibody [ABIN269816] - Mouse Brain. 0.1 mg Log in to see 7 to 9 Days
$317.63
Details
Mouse Rabbit Un-conjugated WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Dog Rabbit Un-conjugated IHC (p) Anti-SCN5A / Nav1.5 antibody  ABIN1049322 IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$221.76
Details
Human Rabbit Un-conjugated WB SCN5A Antibody (N-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC (p), ELISA Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with SCN5A antibody ABIN290512 at 5-10 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details

SCN5A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,
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Top referenced anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antibodies

  1. Cow (Bovine) Polyclonal SCN5A Primary Antibody for WB - ABIN2776347 : Shah, Wingo, Weiss, Williams, Balser, Chazin: Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 5 Pubmed References

  2. Cow (Bovine) Polyclonal SCN5A Primary Antibody for IHC, WB - ABIN2776088 : Van Norstrand, Tester, Ackerman: Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome. in Heart rhythm : the official journal of the Heart Rhythm Society 2008 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal SCN5A Primary Antibody for ELISA, IHC - ABIN269816 : Olson, Michels, Ballew, Reyna, Karst, Herron, Horton, Rodeheffer, Anderson: Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. in JAMA 2005 (PubMed)

More Antibodies against Sodium Channel, Voltage-Gated, Type V, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13 (show FGF13 Antibodies)-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts.

  2. Enhanced A-V conduction in mice overexpressing SCN5A in the heart mimics the human syndrome of Enhanced Atrioventricular Nodal Conduction .

  3. Loss of the C-terminus of connexin43 (show GJA1 Antibodies) limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

  4. Ser571-mediated increases in INa (show INA Antibodies),L promote abnormal repolarization and intracellular Ca(2 (show CA2 Antibodies)+) handling and increase susceptibility to arrhythmia. Ser571 is required for maladaptive remodeling and arrhythmias in response to pressure overload.

  5. intracellular Ca(2 (show CA2 Antibodies)+) contributes to the regulation of INaL conducted by NaV1.5 mutants and propose that, during excitation-contraction coupling, elevated intracellular Ca(2 (show CA2 Antibodies)+) suppresses mutant channel INaL and protects cells from delayed repolarization.

  6. Results show that Nav1.5 upregulation correlates with disease severity in monophasic and chronic-relapsing experimental autoimmune encephalomyelitis and that Nav1.5 expression in astrocytes is modulated in parallel with periods of disease and remission

  7. FoxO1 (show FOXO1 Antibodies) is involved in the modulation of NaV1.5 expression in ischemic heart disease.

  8. Our results suggested that the main expression subtype of sodium channels was Nav1.5 of early embryonic cardiomyocytes.

  9. Data indicate that reduction in connexin43 (Cx43 (show GJA1 Antibodies)) and sodium channel NaV1.5 expression coincided with overexpression of transgene calcineurin A (CnA (show CAN Antibodies)) and hypertrophy development and preceded significant presence of fibrosis.

  10. Expression of NaV1.5 in cardiomyocytes is regulated by the PDZ domain (show INADL Antibodies)-binding motif.

Human Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13 (show FGF13 Antibodies)-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts.

  2. Pathogenic variants in the SCN5A gene modify electrical excitability of sodium cannel that causes an imbalance in the currents of the different ions involved in the contraction process of the cardiomyocytes and induce ventricular remodeling and Dilated cardiomyopathy.

  3. Almost 2% of ARVD (show TGFB3 Antibodies)/C patients harbour rare SCN5A variants. For one of these variants, we demonstrated reduced sodium current, Nav1.5 and N-Cadherin (show CDH2 Antibodies) clusters at junctional sites. This suggests that Nav1.5 is in a functional complex with adhesion molecules, and reveals potential non-canonical mechanisms by which Nav1.5 dysfunction causes cardiomyopathy.

  4. The SCN5A variants R568H and A993T can be classified as pathogenic LQTS3 causing mutations.

  5. Brugada syndrome patients with SCN5A mutations exhibit more conduction abnormalities on ECG.

  6. One common intronic variant in SCN5A is linked with risk of Ventricular Fibrillation caused by first ST-Segment Elevation Myocardial Infarction.

  7. Nav1.5 is hyperacetylated on K1479 in the hearts of patients with cardiomyopathy and clinical conduction disease.

  8. BIMU8 is a potent blocker of hERG (show KCNH2 Antibodies), NaV1.5 and CaV1.2 (show CACNA1C Antibodies) cardiac ion channels, inducing cardiac arrhythmias.

  9. It might be important to suspect the coexistence of DCM and LQT3 (which is rare according to previous articles) in cases with this novel SCN5A missense mutation

  10. Mutational analysis across all 29 exons in SCN5A of the proband and first-degree relatives of the family revealed that the proband inherited a compound heterozygote mutation in SCN5A, specifically p.A226V and p.R1629X from each parent. The study is the first to report a SCN5A compound heterozygote in a Singaporean Chinese family.

Rabbit Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) interaction partners

  1. Freshly dispersed rabbit airway smooth muscle cells express a fast voltage-gated Na(+) current that is mediated mainly by the NaV1.5 subtype.

  2. Mechanisms are determined by a two-dimensional slice model at single-cell and tissue levels in order to determine that SCN5A mutations impair cardiac pacemaking.

Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antigen Profile

Protein Summary

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.

Gene names and symbols associated with SCN5A

  • sodium channel, voltage-gated, type V, alpha subunit (SCN5A) antibody
  • sodium channel, voltage-gated, type V, alpha (Scn5a) antibody
  • sodium channel, voltage-gated, type V, alpha subunit (Scn5a) antibody
  • CDCD2 antibody
  • CMD1E antibody
  • CMPD2 antibody
  • HB1 antibody
  • HB2 antibody
  • HBBD antibody
  • HH1 antibody
  • ICCD antibody
  • IVF antibody
  • LQT3 antibody
  • mH1 antibody
  • Nav1.5 antibody
  • Nav1.5c antibody
  • PFHB1 antibody
  • SCAL antibody
  • SkM1 antibody
  • SkM2 antibody
  • SSS1 antibody
  • VF1 antibody

Protein level used designations for SCN5A

sodium channel, voltage-gated, type V, alpha subunit , voltage-gated sodium channel type V alpha , sodium channel protein type 5 subunit alpha , voltage-gated sodium channel cardiac isoform Nav1.5 , sodium channel protein cardiac muscle subunit alpha , sodium channel protein type V subunit alpha , sodium channel voltage-gated type V alpha polypeptide , sodium channel, voltage-gated, type V, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.5 , cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit , cardiac sodium channel , sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) , voltage-gated sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha polypeptide (long (electrocardiographic) QT syndrome 3) , sodium channel, voltage-gated, type 5, alpha subunit , voltage-gated sodium channel Nav1.5c , oltage-gated sodium channel type V alpha , voltage-dependent sodium channel SCN10A , voltage-gated sodium channel H , voltage-gated sodium channel type V alpha polypeptide

GENE ID SPECIES
747523 Pan troglodytes
100034027 Equus caballus
20271 Mus musculus
6331 Homo sapiens
403497 Canis lupus familiaris
282061 Bos taurus
25665 Rattus norvegicus
395947 Gallus gallus
100009516 Oryctolagus cuniculus
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