anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) Antibodies

The protein encoded by SCN10A is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. Additionally we are shipping Sodium Channel, Voltage-Gated, Type X, alpha Subunit Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN10A 20264 Q6QIY3
SCN10A 6336 Q9Y5Y9
SCN10A 29571 Q62968
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Top anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated AA, ICC, IF, IHC, WB Nav1 8 Cos1 8 transient Western Blotting. Nav1 100 μg Log in to see 2 to 3 Days
$383.90
Details
Human Mouse Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Nav1.8 Antibody (S134-12) [NBP1-47615] - Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Immunohistochemistry: Nav1.8 Antibody (S134-12) [NBP1-47615] - Mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada. 0.1 mg Log in to see 7 to 9 Days
$500.06
Details
Human Mouse HRP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Human Mouse FITC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Human Mouse Biotin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$431.20
Details
Human Mouse PE AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$432.30
Details
Human Mouse Streptavidin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$433.40
Details
Human Mouse APC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$434.50
Details
Human Mouse PerCP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$434.50
Details

SCN10A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit Antibodies

  1. Human Monoclonal SCN10A Primary Antibody for AA, ICC - ABIN863135 : Dray, Read: Arthritis and pain. Future targets to control osteoarthritis pain. in Arthritis research & therapy 2007 (PubMed)
    Show all 3 references for 863135

More Antibodies against Sodium Channel, Voltage-Gated, Type X, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) interaction partners

  1. These preclinical proof-of-concept data suggest that PF-01247324, its derivatives, or other Nav1.8-selective blockers merit further study for providing symptomatic therapy for cerebellar dysfunction in MS and related disorders.

  2. A novel splice variant of SCN10A lacking exon 11 was found in human but not detected in mouse or rat.

  3. Nav1.8 gain-of-function point mutation contributes to intense hyperexcitability along the afferent axon within distinct sensory neuron subtypes.

  4. Nav1.8 interacts with ankyrin G (show ANK3 Antibodies) and they co-localize in skin nerve fibers.

  5. The enhanced NaV1.8 activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain.

  6. Analysis of BAC transgenic strains harboring an engineered deletion of the enhancer within Scn10a revealed t (show SCN5A Antibodies)hat the enhancer was essential for Scn5a expression in cardiac tissue. SCN10A variant rs6801957 modulated Scn5a expression in the heart.

  7. Nav1.8 expression increases in dorsal root ganglion neurons following pretreatment with CC chemokine ligand 2 (show CXCL2 Antibodies).

  8. We demonstrate that 75% of dorsal root ganglion (DRG) neurons express Na(v)1.8-Cre, including >90% of neurons expressing markers of nociceptors.

  9. Behavioural deficits in Nav1.7 (show SCN9A Antibodies)/Nav1.8 knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents.

  10. The functional presence of SCN10A/Nav1.8 in intracardiac neurons is demonstrated, indicating a novel role for this neuronal sodium channel in regulation of cardiac electric activity.

Human Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) interaction partners

  1. Compared with Brugada syndrome (BrS) patients carrying SCN5A (show SCN5A Antibodies) or CACNA1C (show CACNA1C Antibodies) mutations, symptomatic patients in the SCN10A group tended to be older than those in the other gene groups. In six BrS probands who carried SCN10A variants, most experienced severe arrhythmic attacks.

  2. The p.M650K mutation shifted steady-state fast inactivation of Nav1.8 (SCN10A)to more hyperpolarized potentials and did not significantly alter any other tested gating behaviors. The AP half-width was significantly broader and the stimulated action potential firing rate was reduced for M650K transfected DRGs compared to WT.

  3. SCN10A mutations do not play primary role in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

  4. SCN10A genetic variation substantially influences functional status in patients with multiple sclerosis.

  5. SCN10A gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.

  6. The results demonstrate distinct properties of human Na(v)1.8, which contribute to the firing properties of human DRG neurons.

  7. The common SNP SCN10A V1073 was strongly associated with Brugada syndrome and demonstrated loss of NaV1.8 function, as did rare variants in isolated patients.

  8. study suggests that SCN10A variations are involved in the genesis of AF.

  9. Rare SCN10A variants may contribute to atrial fibrillation susceptibility.

  10. The rs6795970 in the SCN10A gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in Hypertrophic Cardiomyopathy patients.

Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) Antigen Profile

Protein Summary

voltage-gated sodium channel that is resistant to tetrodotoxin

Gene names and symbols associated with SCN10A

  • sodium channel, voltage-gated, type X, alpha (Scn10a) antibody
  • sodium channel, voltage-gated, type X, alpha subunit (SCN10A) antibody
  • sodium channel, voltage-gated, type X, alpha subunit (Scn10a) antibody
  • hPN3 antibody
  • Na(V)1.8 antibody
  • Nav1.8 antibody
  • PN3 antibody
  • SNS antibody

Protein level used designations for SCN10A

peripheral nerve sodium channel 3 , sensory neuron sodium channel , sodium channel protein type 10 subunit alpha , sodium channel protein type X subunit alpha , voltage-gated sodium channel subunit alpha Nav1.8 , sodium channel, voltage-gated, type X, alpha polypeptide , sodium channel type X alpha polypeptide , sodium channel voltage-gated type X alpha polypeptide , sodium channel, voltage-gated, type 10, alpha polypeptide , TTX-resistant sodium channel , naNG

GENE ID SPECIES
20264 Mus musculus
6336 Homo sapiens
29571 Rattus norvegicus
477026 Canis lupus familiaris
100299477 Bos taurus
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