Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) ELISA Kits

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Additionally we are shipping Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Antibodies (13) and Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SCN11A SCN11A 24046 Q9R053
Anti-Rat SCN11A SCN11A 29701 O88457
Anti-Human SCN11A SCN11A 11280 Q9UI33
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More ELISA Kits for Sodium Channel, Voltage-Gated, Type XI, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) interaction partners

  1. This study demonstrated that NaV1.9 presumably contributes to acute thermal and mechanical nociception in mice.

  2. These results demonstrate that Nav1.9 channels play a critical role in the development of orofacial neuropathic pain.

  3. Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain syndromes.

  4. A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain.

  5. We conclude that Nav1.9 acts as a subthreshold amplifier in cold-sensitive nociceptive neurons and is required for the perception of cold pain under normal and pathological conditions.

  6. NaV1.9 is required for persistence of responses to intense mechanical stimulation, contributes to inflammatory mechanical hypersensitivity, and is essential for activation by noxious inflammatory mediators, including those from diseased human bowel.

  7. The results strongly suggested that Nav1.9 was expressed and functionally contributed to the signaling processing in the central auditory pathway.

  8. Axon growth of NaV1.9-deficient motoneurons in cell culture is drastically reduce.

  9. In the stable NaV1.9-deficient cells we successfully constructed, proliferation, phagocytosis and migration were obviously inhibited.

  10. Na(V)1.9 function appears to be essential for activity-dependent axon growth in motor neurons, acting upstream of spontaneous Ca(2 (show CA2 ELISA Kits)+) elevation through voltage-gated calcium channels.

Human Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) interaction partners

  1. SCN11A single-nucleotide polymorphisms affect Postoperative pain sensitivity in Chinese Han women after Gynecological surgery. The SNP rs33985936 and rs13080116 may serve as novel predictors for Postoperative pain.

  2. a U-shaped relationship between the resting potential and the neuronal action potential threshold explains why NaV1.9 mutations that evoke small degrees of membrane depolarization cause hyperexcitability and familial episodic pain disorder or painful neuropathy, while mutations evoking larger membrane depolarizations cause hypoexcitability and insensitivity to pain.

  3. Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain syndromes.

  4. Results show the expression of Nav1.9 channels within the human colon for the first time. Furthermore, Nav1.9 channel expression is decreased in Hirschsprung's disease versus normal controls.

  5. autosomal dominant Congenital insensitivity to pain reflects the second gain-of-function mutation of SCN11A.

  6. A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain.

  7. A G699R substitution in the Nav1.9 domain II S4-S5 linker renders dorsal root ganglion neurons hyperexcitable, via depolarized resting membrane potential, reduced current threshold and increased evoked firing in small-fiber neuropathy.

  8. missense mutations of Nav1.9 in individuals with painful peripheral neuropathy

  9. The results demonstrate that Nav1.8 (show SCN10A ELISA Kits) and Nav1.9 are present in human lingual nerve neuromas, with significant correlations between the level of expression of Nav1.8 (show SCN10A ELISA Kits) and symptoms of pain.

  10. we identified a specific de novo missense mutation in SCN11A in individuals with the congenital inability to experience pain who suffer from recurrent tissue damage and severe mutilations.

Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) Antigen Profile

Antigen Summary

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity).

Gene names and symbols associated with SCN11A

  • sodium channel, voltage-gated, type XI, alpha subunit (SCN11A) antibody
  • sodium channel, voltage-gated, type XI, alpha (Scn11a) antibody
  • sodium channel, voltage-gated, type XI, alpha subunit (Scn11a) antibody
  • NaN antibody
  • NaT antibody
  • NAV1.9 antibody
  • NSS2 antibody
  • SCN11A antibody
  • SCN12A antibody
  • SNS-2 antibody
  • SNS2 antibody

Protein level used designations for SCN11A

sodium channel, voltage-gated, type XI, alpha subunit , sodium channel protein type 11 subunit alpha-like , sensory neuron sodium channel 2 , sodium channel protein type 11 subunit alpha , sodium channel protein type XI subunit alpha , sodium channel, voltage-gated, type XI, alpha polypeptide , voltage-gated sodium channel NAV1.9b , voltage-gated sodium channel subunit alpha Nav1.9 , sodium channel voltage-gated type 11 alpha polypeptide , sodium channel voltage-gated type XI alpha polypeptide , sodium channel, voltage-gated, type 11, alpha polypeptide , sodium channel, voltage-gated, type11, alpha polypeptide , PN5 , hNaN , peripheral nerve sodium channel 5 , sodium channel, voltage-gated, type XII, alpha polypeptide , voltage-gated sodium channel Nav1.9

GENE ID SPECIES
460275 Pan troglodytes
100349709 Oryctolagus cuniculus
100414951 Callithrix jacchus
100464374 Ailuropoda melanoleuca
100601668 Nomascus leucogenys
24046 Mus musculus
29701 Rattus norvegicus
11280 Homo sapiens
485593 Canis lupus familiaris
100739142 Sus scrofa
535956 Bos taurus
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