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SCLT1 acts as a linker protein between the voltage-gated sodium channel Na(v)1.8 (SCN10A\; MIM 604427) and clathrin (see CLTC, MIM 118955) (Liu et al., 2005 [PubMed 15797711]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Sclt1 Proteins (3) and many more products for this protein.
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Human Polyclonal Sclt1 Primary Antibody for EIA, IHC (p) - ABIN954690
Liu, Cummins, Tyrrell, Black, Waxman, Dib-Hajj: CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8. in Molecular and cellular neurosciences 2005
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study identified 2 cases with a severe ciliopathy phenotype consistent with oro-facio-digital syndrome type IX; the autozygome of each index harbored a single truncating variant and the affected genes (SCLT1 and TBC1D32/C6orf170 (show C6ORF170 Antibodies)) have roles in centrosomal biology and ciliogenesis; findings suggest a role of SCLT1 and TBC1D32 in ciliopathy pathogenesis
Functional study in rat suggests that CAP-1A links clathrin and a sodium channel.
SCLT1 acts as a linker protein between the voltage-gated sodium channel Na(v)1.8 (SCN10A\; MIM 604427) and clathrin (see CLTC, MIM 118955) (Liu et al., 2005
sodium channel and clathrin linker 1
, sodium channel associated protein 1
, sodium channel-associated protein 1
, clathrin-associated protein 1A
, sodium channel Nav1.8-binding protein