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NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). Additionally we are shipping NALCN Antibodies (46) and many more products for this protein.
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Ohmic leak currents were identified in freshly isolated and cultured myometrial smooth muscle cells. NALCN contributes to this current. Uterine biopsies from term, non-laboring women revealed NALCN messenger RNA and protein expression in the myometrium.
UNC80 encodes a large protein that is necessary for the stability and function of NALCN and for bridging NALCN to UNC79 to form a functional complex
We used exome and targeted next-generation sequencing to identify de novo mutations in NALCN as the cause of a newly delineated condition, CLIFAHDD syndrome.
This study found a plausible association, though not statistically confirmed, of cervical dystonia with SNPs in the NALCN region.
NALCN is the gene responsible for INAD with facial dysmorphism
Two mutations, one missense and one nonsense, in NALCN in two unrelated families.
This study observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk.
UNC80 functions as a scaffold for Src (show SRC Proteins) kinases in NALCN channel function.
Data show the molecular basis of a muscarinic-activated inward sodium current that is independent of G-protein activation, and provide new insights into the properties of NALCN channels.
NALCN is involved in the substance P (show TAC1 Proteins)-induced depolarization of intestinal pacemaking activity in interstitial cells of Cajal.
Study demonstrates that Nalcn associates with serum sodium concentrations in mice and indicates that Nalcn is an important novel player in osmoregulation.
NALCN ion channel is a new actor in pancreatic beta-cell physiology.
Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-unc-80 homolog (C. elegans) protein-non-selective protein voltage gated channel like 1 complex in a G protein-dependent fashion
Unlike any of the other 20 family members, NALCN forms a voltage-independent, nonselective cation channel (show TRPV1 Proteins); NALCN mutant mice have a severely disrupted respiratory rhythm and die within 24 hours of birth.
findings identify NALCN as the cation channel activated by substance P receptor, and suggest that UNC-80 and Src family kinases, rather than a G protein, are involved in the coupling from receptor to channel
NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007
sodium leak channel, non-selective
, voltage gated channel like 1
, sodium leak channel non-selective protein
, four repeat voltage-gated ion channel
, voltage gated channel-like protein 1
, brain voltage-gated cation channel
, four domain-type voltage-gated ion channel alpha-1 subunit