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Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 Proteins (SLC1A6)

Transports L-glutamate and also L- and D-aspartate. Additionally we are shipping Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 Antibodies (42) and Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC1A6 20513 O35544
Rat SLC1A6 SLC1A6 84012 O35921
SLC1A6 6511 P48664
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Top Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC1A6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
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More Proteins for Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 (SLC1A6) Interaction Partners

Mouse (Murine) Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 (SLC1A6) interaction partners

  1. Glutamate (show GRIN1 Proteins) transporters EAAT4 and EAAT5 (show SLC1A7 Proteins) are expressed in vestibular hair cells and calyx endings.

  2. The role of EAAT4 in cortical glutamatergic transmission may be more important than previously thought.

  3. Purkinje cell loss in the Inpp4a (show INPP4A Proteins)(wbl) mutant is due to glutamate (show GRIN1 Proteins) excitotoxicity initiated by the climbing fiber, and that Eaat4 may exert a protective effect.

  4. abnormal expression of EAAT4, GABRA6 (show GABRA6 Proteins), Spi2 combined with lower levels of glutamate (show GRIN1 Proteins) and GABA are likely to be associated with the pathophysiology of Canavan disease.

  5. These results demonstrate that EAAT4 is expressed in astrocytes. This astrocytic localization of neuronal EAAT4 may reveal a new function of EAAT4 in the central nervous system.

  6. EAAT4 mRNA is expressed in the cerebellum of prion protein (show PRNP Proteins)-deficient (PrP-/-) mice presenting with cerebellar ataxia (show USP14 Proteins), at the levels identical to those in the cerebellum of non-ataxic PrP+/- mice

  7. EAAT4 is present in the outer segments, a nonsynaptic region of photoreceptors, where it might provide a feedback mechanism for sensing extracellular glutamate (show GRIN1 Proteins) or serve as an outer barrier to prevent glutamate (show GRIN1 Proteins) from escaping from the retina.

  8. The main role of EAAT4 is to remove low concentrations of glutamate (show GRIN1 Proteins) that escape from the uptake by glial transporters at late times and thus prevent the transmitter from spilling over to neighboring synapses.

  9. This result demonstrates that GLAST (show SLC1A3 Proteins) plays a role in preventing excitotoxic cerebellar damage after ischemia in concert with EAAT4.

  10. The correlation of promoter activity to protein expression makes the EAAT4 BAC promoter reporter a valuable tool to study regulation of EAAT4 expression.

Human Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 (SLC1A6) interaction partners

  1. Decreased SLC1A6 expression in neuregulin 1 (show NRG1 Proteins) risk variant may be an adaptive effect to restore glutamate (show GRIN1 Proteins) signalling in schizophrenia patients.

  2. A twofold difference in functional EAAT4 levels is sufficient to alter signaling to Bergman glia in reporter mice.

  3. strate-dependent gating of anion channels associated with excitatory amino acid transporter 4.

  4. a conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4)

  5. At least one susceptibility locus for schizophrenia may be located within or nearby SLC1A6.

  6. Independent, rather than cooperative anion conductance gating significantly alters predictions of the influence that EAAT4-mediated anion currents will have on synaptic transmission at low glutamate (show GRIN1 Proteins) concentrations.

  7. conclusion, maximal glutamate (show GRIN1 Proteins) transport modulation by SGK1 (show SGK1 Proteins) is accomplished by direct EAAT4 stimulation and to a lesser extent by inhibition of intrinsic Nedd4-2 (show NEDD4L Proteins).

Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 (SLC1A6) Protein Profile

Protein Summary

Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium (By similarity).

Gene names and symbols associated with SLC1A6

  • solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (SLC1A6)
  • solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (slc1a6)
  • solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (LOC100224299)
  • solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (Slc1a6)
  • EAAT4 protein
  • SLC1A6 protein
  • zgc:171923 protein

Protein level used designations for SLC1A6

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 , excitatory amino acid transporter 4 , EAAT1C , EAAT4 , excitatory amino acid transporter SLC1A6 , glastc , excitatory amino acid transporter 4-like , high-affinity neuronal glutamate transporter , sodium-dependent glutamate/aspartate transporter , solute carrier family 1 member 6 , solute carrier family 1, member 6 , high affinity aspartate/glutamate transporter , glutamate transporter

GENE ID SPECIES
420057 Gallus gallus
455789 Pan troglodytes
538673 Bos taurus
559270 Danio rerio
718010 Macaca mulatta
100224299 Taeniopygia guttata
100349456 Oryctolagus cuniculus
100404384 Callithrix jacchus
20513 Mus musculus
84012 Rattus norvegicus
6511 Homo sapiens
403749 Canis lupus familiaris
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