Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 Proteins (SLC10A1)

The protein encoded by SLC10A1 belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Additionally we are shipping SLC10A1 Antibodies (55) and SLC10A1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC10A1 20493 O08705
SLC10A1 6554 Q14973
Rat SLC10A1 SLC10A1 24777 P26435
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Top SLC10A1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 11 to 12 Days
$641.43
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SLC10A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 (SLC10A1) Interaction Partners

Mouse (Murine) Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 (SLC10A1) interaction partners

  1. Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp and Bsep (show ABCB11 Proteins) in liver.

  2. Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate

  3. hepatic transporters Ntcp and Mrp2 (show ABCC2 Proteins) are downregulated in rodent models of necrotizing enterocolitis

  4. Large variations in hepatic bile salt flux have minor effects on expression of murine Ntcp and Bsep (show ABCB11 Proteins) in vivo, suggesting that these transporters are abundantly expressed and able to accommodate a wide range of 'physiological' bile salt fluxes.

  5. Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner (show NR0B2 Proteins). Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression.

  6. Reduced levels of HNF-1alpha (show HNF1A Proteins), RXRalpha (show RXRA Proteins), and RARalpha (show RARA Proteins) in CBDL FXR (show NR1H4 Proteins)-/- mice and reduced DNA binding in CA-fed FXR (show NR1H4 Proteins)-/- mice, despite unchanged Ntcp levels, indicate that these factors may have a minor role in regulation of mouse Ntcp during cholestasis

  7. The C51A and C106A mutants of Slc10a2 showed significantly reduced TCA uptake, while no apparent difference in TCA uptake was observed for the Slc10a1-C44A mutant.

  8. Ntcp and Bsep (show ABCB11 Proteins) are regulated by age, gender, cholestyramine, and bile acid, but resistant to induction by most microsomal enzyme inducers.

  9. mouse Ntcp is regulated by HNF-4alpha (show HNF4A Proteins) via a conserved distal cis (show CISH Proteins)-element independently of HNF-1alpha (show HNF1A Proteins).

  10. Report critical role of PPAR-alpha (show PPARA Proteins) in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Ntcp uptake transporter in mouse liver.

Human Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 (SLC10A1) interaction partners

  1. The data showed that S267F of sodium taurocholate cotransporting polypeptide is not associated with hepatitis B virus infection, and is not prevalent in the general Moroccan population.

  2. The SLC10A1 (NTCP) S267F variant is independently associated with decreased risk of progression to Liver cirrhosis and Hepatocellular Carcinoma , and resistance to Chronic Hepatitis B infection.

  3. In conclusion, NTCP appeared inefficient to mediate infection by serum-derived hepatitis B virus.

  4. Computer screening of NTCP inhibitors and non-inhibitors showed no relationship between the drugs and drug induced liver injury.

  5. We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese

  6. The observation that the pharmacological inhibitors of the NTCP transporter could block HBV entry suggests that NTCP represents an attractive molecular target for therapeutic intervention in HBV infection.

  7. Hepatitis B virus efficiently infects non-adherent hepatoma cells via NTCP, which functions as a virus receptor.

  8. This study suggests that polymorphisms in the NTCP region may be associated with the natural course of HBV infection.

  9. Liver nuclear receptors, FXR and SHP, and bile acid transporters, NTCP and BSEP, are associated with the progression of NAFLD.

  10. Interleukin 6 (show IL6 Proteins) inhibits HBV entry through downregulation of NTCP.

SLC10A1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids\; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.

Gene names and symbols associated with SLC10A1

  • solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (Slc10a1)
  • solute carrier family 10 (sodium/bile acid cotransporter), member 1 (SLC10A1)
  • solute carrier family 10 (sodium/bile acid cotransporter), member 1 (Slc10a1)
  • NTCP protein
  • Ntcp1 protein
  • SBACT protein

Protein level used designations for SLC10A1

Na(+)/bile acid cotransporter , Na(+)/taurocholate transport protein , bile acid cotransporting polypeptide , sodium bile acid cotransporting polypeptide , sodium-taurocholate cotransporting polypeptide , sodium/bile acid cotransporter , sodium/taurocholate cotransporting polypeptide , Na/taurocholate cotransporting polypeptide , cell growth-inhibiting gene 29 protein , growth-inhibiting protein 29 , sodium/taurocholate cotransporter , solute carrier family 10 (sodium/bile acid cotransporter family), member 1 , solute carrier family 10 member 1 , NA-dependent cholate transporting protein , sodium-dependent bile acid cotransporter , sodium-dependent taurocholate cotransporting polypeptide , solute carrier family 10, member 1

GENE ID SPECIES
20493 Mus musculus
6554 Homo sapiens
24777 Rattus norvegicus
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