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Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 Proteins (SLC11A1)

SLC11A1 is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. Additionally we are shipping SLC11A1 Antibodies (30) and SLC11A1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC11A1 6556 P49279
Rat SLC11A1 SLC11A1 316519 P70553
SLC11A1 18173 P41251
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Top SLC11A1 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC11A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1) Interaction Partners

Human Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1) interaction partners

  1. The ratio of FoxA1 (show FOXA1 Proteins) to FoxA2 (show FOXA2 Proteins) in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor (show ASH1L Proteins) LSH (show HELLS Proteins)

  2. The 274C/T polymorphism in exon 3 and the 469+14G/C polymorphism in intron 4 of the Slc11a1/Nramp1 gene were associated with susceptibility to leprosy, while the allele 2 and 3 of the (GT)n polymorphism in the promoter region were associated with susceptibility and protection to leprosy, respectively.

  3. investigation of NRAMP1, MBL (show MBL2 Proteins), MBL (show MBL2 Proteins), VDR (show CYP27B1 Proteins) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis in a Chinese population; study suggests that genotypes of many polymorphic genes are associated with TB

  4. No significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time.

  5. NRAMP1 3'UTR variants were associated with susceptibility to M. tuberculosis infection.

  6. genetic association studies in population in Mexico: Data suggest an SNP in SLC11A1 (D543N, G/A genotype) is associated with treatment failure (after treatment with combinations of antitubercular agents) in male patients with pulmonary tuberculosis.

  7. Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases.

  8. SLC11A1 gene polymorphisms might have a relevant role in the pathology of leishmaniasis, directing towards susceptibility outcome of this disease

  9. Our data provide insights into the possible role of SLC11A1 variation in visceral leishmaniasis susceptibility.

  10. Nramp1 expression is up-regulated by cytokines, and its function helps to produce nitric oxide along with other pro-inflammatory responses. [Review]

Pig (Porcine) Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1) interaction partners

  1. The frequency of allele B and A was 0.93 and 0.90 on a total of 180 and 205 pigs for the polymorphism in intron 1 and intron 2 of the Nramp1 gene respectively in a mixed population of hybrid and purebred pigs.

  2. Genomic organization and polymorphisms detected by denaturing HPLC of porcine NRAMP1 gene are reported.

  3. a significant correlation between different genotypes of Nramp1 gene and immune function and production performance

Cow (Bovine) Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1) interaction partners

  1. Polymorphisms in SLC11A1 and CXCR1 (show CXCR1 Proteins) are significantly associated with bovine mastitis

  2. Analysis of allelic variants in the first and second microsatellite at the 3;UTR region of the SLC11A1 gene in cattle breeds present in Argentina.

  3. Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells.

  4. NRAMP1 consists of multiple targeting motifs for trafficking into lysosomes.

  5. DNA sequence analysis of NRAMP1 gene polymorphisms from 5 different cattle breeds

  6. Identification of a novel polymorphism within the bovine NRAMP 1 gene intron X.

  7. Study compared the frequency of Nramp1 3'UTR polymorphisms between Zebu and European bovine breeds.

  8. The expression of iNOS (show NOS2 Proteins) and NRAMP1 in the lymph nodes, lungs, and tuberculous granulomas in 8 bovine tuberculosis cases is reported.

  9. These results indicate that these polymorphisms at the NRAMP1 3'UTR do not affect resistance against B. abortus in cattle.

  10. Genotype of the SLC11A1 gene is associated with resistance to brucellosis.

Mouse (Murine) Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1) interaction partners

  1. discrete, anatomically localized host resistance is conferred by Nramp1 expression; restriction of systemic bacterial growth in the spleen is enhanced by Nramp1 expression

  2. Data shows that Lsh (show HELLS Proteins) plays an essential Dnmt3b (show DNMT3B Proteins)-independent role to ensure that the host genome integrity is protected from potentially deleterious LTR retroelements.

  3. Gene expression profiles of the two arthritis quantitative trait loci (on chromosomes 5 and 8) correlate with Slc11a1 alleles, resulting in enhanced AIRmax(SS) mice susceptibility to Pristane-induced arthritis.

  4. In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage.

  5. These observations indicate a bifunctional protective role of secretory Prx (show PRX Proteins); first it reduces redox activation of macrophages, and secondly it allows iron access to Leishmania by down regulating NRAMP1 expression.

  6. Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells.

  7. Stimulation of Lcn2 (show LCN2 Proteins) expression is a novel mechanism by which Nramp1 confers resistance against infection with Salmonella typhimurium.

  8. High inflammatory AIRmax mice homozygous for Slc11a1 R and S alleles were produced. The Slc11a1 gene modulated the early inflammatory events of ear tissue regeneration.

  9. anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin (show HAMP Proteins) expression, is influenced by Nramp1 and may involve lipocalin-2 (show LCN2 Proteins).

  10. The Yersinia pseudotuberculosis mntH mutant was defective in survival and growth in macrophages expressing functional Nramp1, but in macrophages deficient in Nramp the bacteria were able to survive and replicate.

SLC11A1 Protein Profile

Protein Summary

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Gene names and symbols associated with SLC11A1

  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (slc11a1)
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (SLC11A1)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (SLC11A1)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (Slc11a1)
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (Slc11a1)
  • BCG protein
  • Itg protein
  • ity protein
  • Lsh protein
  • Nramp protein
  • Nramp1 protein
  • SLC11A1 protein

Protein level used designations for SLC11A1

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 , natural resistance associated macrophage protein 1 , natural resistance-associated macrophage protein 1 , natural resistance-associated macrophage protein 1-like , NRAMP 1 , solute carrier family 11 (sodium/phosphate symporters), member 1 , solute carrier family 11 member 1 , host resistance locus Bcg/Ity/Lsh , natural resistant-associated macrophage protein 1 , natural resistance associated macrophage protein

GENE ID SPECIES
494699 Xenopus laevis
701025 Macaca mulatta
741434 Pan troglodytes
100033912 Equus caballus
100388929 Callithrix jacchus
100446791 Pongo abelii
100601194 Nomascus leucogenys
6556 Homo sapiens
316519 Rattus norvegicus
478909 Canis lupus familiaris
396764 Sus scrofa
282470 Bos taurus
18173 Mus musculus
395811 Gallus gallus
443365 Ovis aries
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