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The protein encoded by SLC12A2 mediates sodium and chloride transport and reabsorption. Additionally we are shipping SLC12A2 Proteins (9) and SLC12A2 Kits (2) and many more products for this protein.
Showing 10 out of 88 products:
Cow (Bovine) Polyclonal SLC12A2 Primary Antibody for WB - ABIN2773831
Panet, Eliash, Atlan: Na+/K+/Cl- cotransporter activates MAP-kinase cascade downstream to protein kinase C, and upstream to MEK. in Journal of cellular physiology 2005
Show all 3 references for ABIN2773831
Human Polyclonal SLC12A2 Primary Antibody for EIA, IHC (fro) - ABIN1109023
Hannemann, Flatman: Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells. in PLoS ONE 2011
Human Polyclonal SLC12A2 Primary Antibody for ELISA, IHC - ABIN4339820
Pawelczyk, Van Laer, Fransen, Rajkowska, Konings, Carlsson, Borg, Van Camp, Sliwinska-Kowalska: Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss. in Annals of human genetics 2009
NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients and EGFR (show EGFR Antibodies)-mutated subgroup. Therefore, NKCC1 may play a role in lung adenocarcinoma and novel therapeutic tactics could be developed by targeting NKCC1 protein.
Study describes a functional missense variant in SLC12A2 in human schizophrenia, and suggest that genetically encoded dysregulation of NKCC1 may be a risk factor for, or contribute to the pathogenesis of, schizophrenia
The NKCC-1 is a Na(+)- dependent Cl(-) transporter that mediates the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane and maintains cell volume and intracellular K(+) and Cl(-) homeostasis.
NKCC1 labeling was seen only in the basolateral membrane of the secretory coils.
Suggest that the expression of NKCC1 in esophageal squamous cell carcinoma may affect the G2/M checkpoint and may be related to the degree of histological differentiation of SCCs.
Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteines.
our data show a novel role for the WNK1 (show WNK1 Antibodies)/OSR1 (show OXSR1 Antibodies)/NKCC1 pathway in glioma migration
Reduced KCC2 (show SLC12A5 Antibodies)/NKCC1 ratio in the cerebrospinal fluid of Rett Syndrome patients suggests a disturbed process of GABAergic neuronal maturation and open up a new therapeutic perspective.
The hormone aldosterone was found to upregulate NKCC1 by increasing protein stability.
Altered hippocampal area function and coupling in DISC1 (show DISC1 Antibodies) and SLC12A2 minor allele carriers.
NKCC1 inhibition protects neurons from traumatic brain injury via regulation of the ERK (show EPHB2 Antibodies) signal pathway.
We conclude that TRPV2 (show TRPV2 Antibodies) is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK (show STK39 Antibodies)-activated NKCC1
KCC2 (show SLC12A5 Antibodies) expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.
GnRH (show GNRH1 Antibodies) neurons were immunopositive for NKCC1 and AE2 (show SLC4A2 Antibodies).
NKCC1 may have a role in periventricular leukomalacia, as shown by bumetanide protection against white matter injury in a rodent model
our results suggest that NKCCs are involved in insulin (show INS Antibodies) secretion and that a single Slc12a2 allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1 (show SLC12A1 Antibodies).
Repeated stress decreased KCC2 (show SLC12A5 Antibodies) expression and increased NKCC1 expression in membranes of granular and pyramidal cells in the hippocampus.
Data indicate that ion transporter NKCC1 is involved in chloride accumulation but also reveals an impact in neurogenesis.
NKCC1 appeared down regulated in age related hearing loss.
The FAK (show PTK2 Antibodies) inhibitor PF-573,228 augmented shrinkage-induced Src (show SRC Antibodies) phosphorylation, and inhibited shrinkage-induced NKCC1 activity.
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
, solute carrier family 12 member 2-like
, basolateral Na-K-Cl symporter
, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
, solute carrier family 12 member 2
, solute carrier family 12, member 2
, basolateral NaK(2Cl) cotransporter
, sodium/potassium/chloride cotransporters
, sodium/potassium/chloride transporters