You are viewing an incomplete version of our website. Please click to reload the website as full version.

Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Proteins (SLC12A6)

SLC12A6 is a member of the K-Cl cotransporter (KCC) family. Additionally we are shipping Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SLC12A6 SLC12A6 691209  
SLC12A6 9990 Q9UHW9
SLC12A6 107723 Q924N4
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC12A6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) Interaction Partners

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) interaction partners

  1. These results suggest that the expression of KCC3 in ESCC may affect cellular invasion and be related to a worse prognosis in patients with ESCC.

  2. SPAK (show STK39 Proteins) may promote KCC3-mediated cervix tumor aggressiveness via the NF-kappaB (show NFKB1 Proteins)/p38 MAPK (show MAPK14 Proteins)/MMP2 (show MMP2 Proteins) axis.

  3. SLC12A6 has been shown to be causative in Andermann Syndrome.

  4. serine residue 96 of human KCC3 is a third site that has to be dephosphorylated for full activation of the cotransporter during hypotonicity.

  5. mis (show AMH Proteins)-trafficking of mutant protein is an important pathophysiological feature of HMSN/ACC causative KCC3 mutations.

  6. Neuropathic features of hereditary motor and sensory neuropathy/agenesis of corpus callosum in transgenic mouse lines are predominantly due to a neuronal KCC3 deficit, while the auditory impairment is due to loss of non-neuronal KCC3 expression.

  7. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Proteins)/2 and NCC (show SLC12A3 Proteins) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  8. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Proteins) and KCC4 (show SLC12A7 Proteins) that could result in modulation of KCC activity

  9. mutations of the KCC3 gene may result in non-syndromic childhood onset of demyelinating hereditary motor and sensory neuropathy

  10. all of the CCCs examined (NKCC1 (show SLC12A2 Proteins), NKCC2 (show SLC12A1 Proteins), KCC1 (show SLC12A4 Proteins), KCC3, and KCC4 (show SLC12A7 Proteins)) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) interaction partners

  1. The results establish that the parvalbumin (show PVALB Proteins)-positive neuronal population is an important player in the pathogenic development of peripheral neuropathy associated with agenesis of the corpus callosum.

  2. Data are consistent with a role for KCC3 in the proximal tubule glucose reabsorption mechanism.

  3. KCC3 regulates NADPH oxidase (show NOX1 Proteins) activity and neutrophils activation

  4. KCC3 contributes to Cl(-) extrusion in adult sensory neurons

  5. K+-Cl-cotransporter (show SLC12A4 Proteins) KCC3 is expressed in neurons, interneurons and radial glial-like cells in the spinal cord.

  6. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Proteins) and KCC4 (show SLC12A7 Proteins) that could result in modulation of KCC activity

  7. This study demonstrated that the K(+)-Cl(-) cotransporter (show SLC12A4 Proteins) activity of KCC3 contributes to the propagation of action potentials along peripheral nerves.

  8. Expression of Slc12a6 in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase (show COMT Proteins)).

  9. SLC12A6 has a role in the development and maintenance of the nervous system

  10. Ste20 (show STK24 Proteins)-related proline-alanine-rich kinase (SPAK (show STK39 Proteins)) and oxidative stress response 1 (OSR1 (show OSR1 Proteins)) with the cotransporters KCC3, NKCC1 (show SLC12A2 Proteins), and NKCC2 (show SLC12A1 Proteins) but not KCC1 (show SLC12A4 Proteins) and KCC4 (show SLC12A7 Proteins)

Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) Protein Profile

Protein Summary

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

Gene names and symbols associated with SLC12A6

  • solute carrier family 12, member 6 (Slc12a6)
  • solute carrier family 12 (potassium/chloride transporter), member 6 (SLC12A6)
  • 9530023I19Rik protein
  • ACCPN protein
  • gaxp protein
  • KCC3 protein
  • KCC3A protein
  • KCC3B protein

Protein level used designations for SLC12A6

solute carrier family 12 member 6 , furosemide-sensitive KCl cotransporter 3 , K-Cl cotransporter 3 , electroneutral potassium-chloride cotransporter 3 , potassium chloride cotransporter 3 , potassium chloride cotransporter KCC3a-S3 , potassium-chloride transporter-3a , potassium-chloride transporter-3b , solute carrier family 12 (potassium/chloride transporters), member 6

GENE ID SPECIES
691209 Rattus norvegicus
9990 Homo sapiens
107723 Mus musculus
Selected quality suppliers for Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Proteins (SLC12A6)
Did you look for something else?