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anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) Antibodies

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. Additionally we are shipping SLC12A7 Proteins (7) and SLC12A7 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC12A7 10723 Q9Y666
SLC12A7 308069 Q5RK27
SLC12A7 20499 Q9WVL3
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Top anti-SLC12A7 Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Rabbit Un-conjugated IHC (p), WB SLC12A7 Antibody (N-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SLC12A7 antibody detected the SLC12A7 protein (arrow). SLC12A7 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC12A7 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 μg of whole cell lysate) A:H1299 7.5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days
$610.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Mouse Rabbit Un-conjugated EIA, IHC (fro), IF, WB   0.2 mL Log in to see 6 to 8 Days
$533.50
Details
Rat Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 8 to 10 Days
$566.50
Details
Mouse Rabbit Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days
$610.50
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

SLC12A7 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SLC12A7 Antibodies

  1. Human Polyclonal SLC12A7 Primary Antibody for ELISA, WB - ABIN238577 : Simard, Bergeron, Frenette-Cotton, Carpentier, Pelchat, Caron, Isenring: Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters. in The Journal of biological chemistry 2007 (PubMed)

  2. Mouse (Murine) Polyclonal SLC12A7 Primary Antibody for EIA, IHC (fro) - ABIN1109025 : Blessing: 5-hydroxytryptamine 1A receptor activation reduces cutaneous vasoconstriction and fever associated with the acute inflammatory response in rabbits. in Neuroscience 2003 (PubMed)

More Antibodies against SLC12A7 Interaction Partners

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) interaction partners

  1. SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis.

  2. The Wnk3 (show WNK3 Antibodies) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Antibodies)/2 and NCC (show SLC12A3 Antibodies) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  3. KCC3 (show SLC12A6 Antibodies) is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Antibodies) and KCC4 that could result in modulation of KCC activity

  4. Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 (show AQP1 Antibodies) water channel (show AQP4 Antibodies), revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly.

  5. analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 (show SLC12A5 Antibodies) and KCC4

  6. KCC activation by IGF-1 (show IGF1 Antibodies) plays an important role in IGF-1 (show IGF1 Antibodies) signaling to promote growth and spread of gynecological cancers.

  7. Among patients with early-stage node-negative breast cancer, disease-free survival (DFS (show FST Antibodies)) and overall survival (OS) curves were significantly different based on IGF-1 (show IGF1 Antibodies) and KCC expression.

  8. KCC4 and H+,K+-ATPase (show ATP1A1 Antibodies) are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.

  9. In the metastatic cancer tissues, KCC4 colocalizes with IGF-I (show IGF1 Antibodies) or EGF (show EGF Antibodies).

  10. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7) interaction partners

  1. Data are consistent with a role for KCC4 in salt reabsorption of the thick ascending loop of Henle's loop and acid secretion of the collecting duct.

  2. We propose that glycosylation is essential for the surface expression, stabilization, and bioactivity of KCC4

  3. KCC3 (show SLC12A6 Antibodies) is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Antibodies) and KCC4 that could result in modulation of KCC activity

  4. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.

  5. Ste20 (show STK24 Antibodies)-related proline-alanine-rich kinase (SPAK (show STK39 Antibodies)) and oxidative stress response 1 (OSR1 (show OSR1 Antibodies)) with the cotransporters KCC3 (show SLC12A6 Antibodies), NKCC1 (show SLC12A2 Antibodies), and NKCC2 (show SLC12A1 Antibodies) but not KCC1 (show SLC12A4 Antibodies) and KCC4

  6. all of the CCCs examined (NKCC1 (show SLC12A2 Antibodies), NKCC2 (show SLC12A1 Antibodies), KCC1 (show SLC12A4 Antibodies), KCC3 (show SLC12A6 Antibodies), and KCC4) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site

  7. KCC4 and H+,K+-ATPase (show ATP1A1 Antibodies) are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.

SLC12A7 Antigen Profile

Protein Summary

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).

Gene names and symbols associated with SLC12A7

  • solute carrier family 12 (potassium/chloride transporters), member 7 (SLC12A7) antibody
  • solute carrier family 12 (potassium/chloride transporter), member 7 (SLC12A7) antibody
  • solute carrier family 12 (potassium/chloride transporter), member 7 (Slc12a7) antibody
  • solute carrier family 12, member 7 (Slc12a7) antibody
  • AA408796 antibody
  • D13Ertd261e antibody
  • Kcc4 antibody
  • Slc12a5 antibody
  • SLC12A7 antibody

Protein level used designations for SLC12A7

solute carrier family 12 (potassium/chloride transporters), member 7 , K-Cl cotransporter 4 , electroneutral potassium-chloride cotransporter 4 , potassium/chloride transporter KCC4 , solute carrier family 12 member 7 , K-Cl cotransporter KCC4 , furosemide-sensitive KCl cotransporter 4 , potassium-chloride cotransporter

GENE ID SPECIES
528038 Bos taurus
709581 Macaca mulatta
10723 Homo sapiens
308069 Rattus norvegicus
100008847 Oryctolagus cuniculus
20499 Mus musculus
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