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SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. Additionally we are shipping Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteins (11) and Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Kits (3) and many more products for this protein.
Showing 10 out of 64 products:
Dog (Canine) Polyclonal SLC12A3 Primary Antibody for IEM, ICC - ABIN863201
Rosenbaek, Assentoft, Pedersen, MacAulay, Fenton: Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. in The Journal of physiology 2012
Show all 10 references for ABIN863201
Human Polyclonal SLC12A3 Primary Antibody for IF (p), IHC (p) - ABIN872340
Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. in Biology of sex differences 2015
SLC12A3 gene homozygous mutation is associated with Gitelman syndrome.
SNPs in the SLC12A3 gene confer susceptibility to hypertension in the Mongolian population.
Compared with patients with 1 mutant SLC12A3 allele, patients with 2 mutant SLC12A3 alleles had more severe hypomagnesemia, but did not have more severe hypokalemia.
the results of this study support that the SLC12A3 gene is a susceptibility gene for hypertension in the Mongolian population.
Suggest NCC1 (show CCL13 Antibodies)/2 is a fully functional thiazide-sensitive NaCl-transporting protein in the kidney.
Low SLC12A3 urine levels were associated with Gitelman syndrome.
association between thiazide-sensitive Na(+)-Cl(-) cotransporter mutants and human hypertension as well as Gitelman's syndrome (review).
In urinary exosomes, NCC and prostasin (show PRSS8 Antibodies) had a diurnal pattern parallel to ADH (show AVP Antibodies) and aquaporin 2 (show AQP2 Antibodies), confirming that, in healthy subjects, both prostasin (show PRSS8 Antibodies) and NCC relate to water balance.
Data from two families in China suggest two homozygous mutations in SLC12A3 (Arg928Cys or Ser710X) can be associated with Gitelman syndrome; members of two families exhibit additional mutations and heterogenicity of clinical phenotype. [CASE STUDY]
SLC12A3 Arg913Gln polymorphism was associated with Type 2 diabetes and diabetic (show LEPR Antibodies) nephropathy in the Malaysian cohort. The meta-analysis confirmed the protective effects of SLC12A3 913Gln allele in diabetic nephropathy.
the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4 (show WNK4 Antibodies)-SPAK (show STK39 Antibodies) signal pathway using WNK4 (show WNK4 Antibodies)-/- and SPAK (show STK39 Antibodies)-/- mice.
The Role of Epithelial Sodium Channel ENaC (show SCNN1A Antibodies) and the Apical Cl-/HCO3- Exchanger Pendrin (show SLC26A4 Antibodies) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.
This study identifies NCC as an IL18 (show IL18 Antibodies)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.
Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (show LEPR Antibodies) mice from 6, 12, and 26 weeks at the age.
SPAK (show STK39 Antibodies)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.
NCC inhibition stimulates duodenal Ca(2 (show CA2 Antibodies)+) absorption as well as osteoblast differentiation and bone Ca(2 (show CA2 Antibodies)+) storage, possibly through a FAK (show PTK2 Antibodies)/ERK (show EPHB2 Antibodies) dependent mechanism
P2Y2 (show P2RY2 Antibodies)-mediated increase of cytoplasmic Ca(2 (show CA2 Antibodies)+) concentration down-regulates the expression of NCC.
Estradiol, progesterone, and prolactin (show PRL Antibodies) increase renal NaCl cotransporter phosphorylation and activity.
SPAK (show STK39 Antibodies) is an important mediator of the increased NCC activation by phosphorylation that occurs in the distal convoluted tubule in response to a low-K(+) diet, but other low-potassium-activated kinases are likely to be involved.
WNK4 (show WNK4 Antibodies) is the major positive regulator of NCC in the kidneys.
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
solute carrier family 12 (sodium/chloride transporters), member 3
, thiazide-sensitive sodium chloride cotransporter
, solute carrier family 12 (sodium/chloride transporters), member 3, gene 2
, solute carrier family 12 member 3-like
, Na-Cl cotransporter
, Na-Cl symporter
, NaCl electroneutral thiazide-sensitive cotransporter
, solute carrier family 12 member 3
, thiazide-sensitive Na-Cl cotransporter
, thiazide-sensitive sodium-chloride cotransporter
, solute carrier family 12, member 3
, sodium chloride cotransporter