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Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteins (SLC12A3)

SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. Additionally we are shipping Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Antibodies (80) and Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC12A3 6559 P55017
Rat SLC12A3 SLC12A3 54300 P55018
SLC12A3 20497 P59158
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Top Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteins at antibodies-online.com

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$492.80
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$684.50
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HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
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SLC12A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Interaction Partners

Human Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. Compared with patients with 1 mutant SLC12A3 allele, patients with 2 mutant SLC12A3 alleles had more severe hypomagnesemia, but did not have more severe hypokalemia.

  2. the results of this study support that the SLC12A3 gene is a susceptibility gene for hypertension in the Mongolian population.

  3. Suggest NCC1 (show CCL13 Proteins)/2 is a fully functional thiazide-sensitive NaCl-transporting protein in the kidney.

  4. Low SLC12A3 urine levels were associated with Gitelman syndrome.

  5. association between thiazide-sensitive Na(+)-Cl(-) cotransporter mutants and human hypertension as well as Gitelman's syndrome (review).

  6. In urinary exosomes, NCC and prostasin (show PRSS8 Proteins) had a diurnal pattern parallel to ADH (show AVP Proteins) and aquaporin 2 (show AQP2 Proteins), confirming that, in healthy subjects, both prostasin (show PRSS8 Proteins) and NCC relate to water balance.

  7. Data from two families in China suggest two homozygous mutations in SLC12A3 (Arg928Cys or Ser710X) can be associated with Gitelman syndrome; members of two families exhibit additional mutations and heterogenicity of clinical phenotype. [CASE STUDY]

  8. SLC12A3 Arg913Gln polymorphism was associated with Type 2 diabetes and diabetic (show LEPR Proteins) nephropathy in the Malaysian cohort. The meta-analysis confirmed the protective effects of SLC12A3 913Gln allele in diabetic nephropathy.

  9. the SLC12A3 34372 AA genotype is associated with a reduced risk of diabetes.

  10. Identification of candidate mutations in the SLC12A3 gene that may induce exon skipping.

Mouse (Murine) Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. The Role of Epithelial Sodium Channel ENaC (show SCNN1A Proteins) and the Apical Cl-/HCO3- Exchanger Pendrin (show SLC26A4 Proteins) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.

  2. This study identifies NCC as an IL18 (show IL18 Proteins)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.

  3. Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (show LEPR Proteins) mice from 6, 12, and 26 weeks at the age.

  4. SPAK (show STK39 Proteins)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.

  5. NCC inhibition stimulates duodenal Ca(2 (show CA2 Proteins)+) absorption as well as osteoblast differentiation and bone Ca(2 (show CA2 Proteins)+) storage, possibly through a FAK (show PTK2 Proteins)/ERK (show EPHB2 Proteins) dependent mechanism

  6. P2Y2 (show P2RY2 Proteins)-mediated increase of cytoplasmic Ca(2 (show CA2 Proteins)+) concentration down-regulates the expression of NCC.

  7. Estradiol, progesterone, and prolactin (show PRL Proteins) increase renal NaCl cotransporter phosphorylation and activity.

  8. SPAK (show STK39 Proteins) is an important mediator of the increased NCC activation by phosphorylation that occurs in the distal convoluted tubule in response to a low-K(+) diet, but other low-potassium-activated kinases are likely to be involved.

  9. WNK4 (show WNK4 Proteins) is the major positive regulator of NCC in the kidneys.

  10. Kcnj10 (show KCNJ10 Proteins) is a main contributor to the basolateral K conductance in the early distal convoluted tubule (DCT1 (show SLC11A2 Proteins)) and determines the expression of the apical Na-Cl cotransporter (NCC) in the DCT (show DCT Proteins).

Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Protein Profile

Protein Summary

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC12A3

  • solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3)
  • thiazide-sensitive sodium chloride cotransporter (NCCT)
  • solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 (slc12a3.2)
  • solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3)
  • solute carrier family 12 (sodium/chloride transporter), member 3 (Slc12a3)
  • solute carrier family 12, member 3 (Slc12a3)
  • AI035291 protein
  • DKFZp469N2315 protein
  • NCC protein
  • NCCT protein
  • slc12a3 protein
  • TSC protein

Protein level used designations for SLC12A3

solute carrier family 12 (sodium/chloride transporters), member 3 , thiazide-sensitive sodium chloride cotransporter , solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 , solute carrier family 12 member 3-like , Na-Cl cotransporter , Na-Cl symporter , NaCl electroneutral thiazide-sensitive cotransporter , solute carrier family 12 member 3 , thiazide-sensitive Na-Cl cotransporter , thiazide-sensitive sodium-chloride cotransporter , solute carrier family 12, member 3 , sodium chloride cotransporter

GENE ID SPECIES
415692 Gallus gallus
454108 Pan troglodytes
703090 Macaca mulatta
100009348 Oryctolagus cuniculus
100038063 Xenopus (Silurana) tropicalis
100051953 Equus caballus
100172399 Pongo abelii
100409101 Callithrix jacchus
100468795 Ailuropoda melanoleuca
100015656 Monodelphis domestica
6559 Homo sapiens
54300 Rattus norvegicus
478118 Canis lupus familiaris
404171 Bos taurus
20497 Mus musculus
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