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SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. Additionally we are shipping SLC12A1 Proteins (9) and SLC12A1 Kits (8) and many more products for this protein.
Showing 10 out of 69 products:
Human Polyclonal SLC12A1 Primary Antibody for WB - ABIN863200
Caceres, Ares, Ortiz: cAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase A. in The Journal of biological chemistry 2009
Show all 5 references for ABIN863200
Human Polyclonal SLC12A1 Primary Antibody for DB, EIA - ABIN493167
Nogues, Lang, Desbat, Buffeteau, Leiserowitz: Two-dimensional crystal structure of a quaterthiophene-alkanethiol self-assembled monolayer on gold. in Langmuir : the ACS journal of surfaces and colloids 2008
Show all 4 references for ABIN493167
Human Polyclonal SLC12A1 Primary Antibody for WB - ABIN2486327
Xue, Liu, Ji, Ren, Zhang, Zheng, Wood, Zhu: Expression of NKCC2 in the rat gastrointestinal tract. in Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2009
Show all 2 references for ABIN2486327
Chicken Polyclonal SLC12A1 Primary Antibody for IHC, WB - ABIN2776780
Kelsen, Patel, Parker, Vera, Rimoldi, Gadepalli, Drummond, Stec: Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells. in American journal of physiology. Renal physiology 2008
Show all 2 references for ABIN2776780
Low SLC12A1 urine levels were associated with Bartter syndrome.
Mutations in SLC12A1 gene is associated with Bartter syndrome.
Urinary NKCC2 increased in chronic kidney disease patients and decreased in controls in response to hypertonic saline.
The association between polymorphisms in KCNJ1 (show KCNJ1 Antibodies), SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.
overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.
NKCC2 mutations result in impaired apical targeting and function of NKCC2 transporter and give rise to a pathological phenotype known as type I Bartter syndrome. (Review)
Data show that intracellular association between WNK1 (show WNK1 Antibodies) and oxidative stress-responsive 1 (OSR1 (show OXSR1 Antibodies)) is required for stimulation of OSR1 (show OXSR1 Antibodies) and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (show SLC12A2 Antibodies) and NKCC2 activities by osmotic stress.
NKCC1 (show SLC12A2 Antibodies) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.
The Wnk3 (show WNK3 Antibodies) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Antibodies)/2 and NCC (show SLC12A3 Antibodies) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
two mutations in the SLC12A1 among patients suffering from bartter and Gitelman syndromes
Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing.
The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha (show SCNN1A Antibodies) in obstructive kidney disease, possibly via iNOS (show NOS2 Antibodies)-derived nitric oxide and BNP (show BNC2 Antibodies).
our results suggest that NKCCs are involved in insulin (show INS Antibodies) secretion and that a single Slc12a2 (show SLC12A2 Antibodies) allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1.
Vasopressin (show AVP Antibodies) plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport.
In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described.
increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase
Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs.
NKCC2A-dependent activation of NFAT5 (show NFAT5 Antibodies) is part of a pathway by which the medullary thick ascending limb produces TNF (show TNF Antibodies) in response to hypertonic NaCl intake.
Abnormal anterograde trafficking as a common mechanism associated with mutations depriving NKCC2.
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
FERM domain-containing protein 4A
, Na/K/Cl cotransporter
, solute carrier family 12 (sodium/potassium/chloride transporters), member 1
, solute carrier family 12 member 1-like
, NKCC2A variant A
, Na-K-2Cl cotransporter
, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
, kidney-specific Na-K-Cl symporter
, solute carrier family 12 member 1
, Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
, Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
, apical Na(2Cl)K cotransporter
, solute carrier family 12, member 1
, bumetanide-sensitive cotransporter type 1