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Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) ELISA Kits

SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. Additionally we are shipping SLC12A1 Antibodies (72) and SLC12A1 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SLC12A1 6557 Q13621
SLC12A1 25065  
SLC12A1 20495 P55014
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Top SLC12A1 ELISA Kits at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 12.7 pg/mL 31.25-2000 pg/mL 96 Tests Log in to see 9 to 11 Days
$736.84
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Rat
  96 Tests Log in to see 11 to 13 Days
$875.60
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Mouse
  96 Tests Log in to see 11 to 13 Days
$875.60
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Please inquire
  10 reactions Log in to see 4 to 6 Days
$549.00
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More ELISA Kits for SLC12A1 Interaction Partners

Human Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) interaction partners

  1. Low SLC12A1 urine levels were associated with Bartter syndrome.

  2. Mutations in SLC12A1 gene is associated with Bartter syndrome.

  3. Urinary NKCC2 increased in chronic kidney disease patients and decreased in controls in response to hypertonic saline.

  4. The association between polymorphisms in KCNJ1 (show KCNJ1 ELISA Kits), SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  5. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.

  6. NKCC2 mutations result in impaired apical targeting and function of NKCC2 transporter and give rise to a pathological phenotype known as type I Bartter syndrome. (Review)

  7. Data show that intracellular association between WNK1 (show WNK1 ELISA Kits) and oxidative stress-responsive 1 (OSR1 (show OXSR1 ELISA Kits)) is required for stimulation of OSR1 (show OXSR1 ELISA Kits) and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (show SLC12A2 ELISA Kits) and NKCC2 activities by osmotic stress.

  8. NKCC1 (show SLC12A2 ELISA Kits) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.

  9. The Wnk3 (show WNK3 ELISA Kits) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 ELISA Kits)/2 and NCC (show SLC12A3 ELISA Kits) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  10. two mutations in the SLC12A1 among patients suffering from bartter and Gitelman syndromes

Mouse (Murine) Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) interaction partners

  1. Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing.

  2. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  3. our results suggest that NKCCs are involved in insulin (show INS ELISA Kits) secretion and that a single Slc12a2 (show SLC12A2 ELISA Kits) allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1.

  4. Vasopressin (show AVP ELISA Kits) plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport.

  5. In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described.

  6. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase

  7. Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs.

  8. NKCC2A-dependent activation of NFAT5 (show NFAT5 ELISA Kits) is part of a pathway by which the medullary thick ascending limb produces TNF (show TNF ELISA Kits) in response to hypertonic NaCl intake.

  9. Abnormal anterograde trafficking as a common mechanism associated with mutations depriving NKCC2.

  10. NKCC1 (show SLC12A2 ELISA Kits) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.

SLC12A1 Antigen Profile

Antigen Summary

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Gene names and symbols associated with SLC12A1

  • si:ch211-220f12.1 (si:ch211-220f12.1) antibody
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (SLC12A1) antibody
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1) antibody
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (Slc12a1) antibody
  • solute carrier family 12, member 1 (Slc12a1) antibody
  • AI788571 antibody
  • BSC1 antibody
  • D630042G03Rik antibody
  • DKFZp469A2020 antibody
  • mBSC1 antibody
  • Nkcc2 antibody
  • SLC12A1 antibody
  • urehr3 antibody

Protein level used designations for SLC12A1

FERM domain-containing protein 4A , Na/K/Cl cotransporter , solute carrier family 12 (sodium/potassium/chloride transporters), member 1 , solute carrier family 12 member 1-like , NKCC2A variant A , Na-K-2Cl cotransporter , bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 , kidney-specific Na-K-Cl symporter , solute carrier family 12 member 1 , Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , apical Na(2Cl)K cotransporter , solute carrier family 12, member 1 , BSC1 , bumetanide-sensitive cotransporter type 1

GENE ID SPECIES
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714289 Macaca mulatta
100025723 Monodelphis domestica
100173185 Pongo abelii
100414428 Callithrix jacchus
100590969 Nomascus leucogenys
6557 Homo sapiens
25065 Rattus norvegicus
415433 Gallus gallus
478292 Canis lupus familiaris
407161 Bos taurus
100328575 Oryctolagus cuniculus
20495 Mus musculus
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