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Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 Proteins (SLC12A1)

SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. Additionally we are shipping SLC12A1 Antibodies (68) and SLC12A1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC12A1 6557 Q13621
SLC12A1 25065  
SLC12A1 20495 P55014
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Top SLC12A1 Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SLC12A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaction Partners

Human Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) interaction partners

  1. Low SLC12A1 urine levels were associated with Bartter syndrome.

  2. Mutations in SLC12A1 gene is associated with Bartter syndrome.

  3. Urinary NKCC2 increased in chronic kidney disease patients and decreased in controls in response to hypertonic saline.

  4. The association between polymorphisms in KCNJ1 (show KCNJ1 Proteins), SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  5. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.

  6. NKCC2 mutations result in impaired apical targeting and function of NKCC2 transporter and give rise to a pathological phenotype known as type I Bartter syndrome. (Review)

  7. Data show that intracellular association between WNK1 (show WNK1 Proteins) and oxidative stress-responsive 1 (OSR1 (show OXSR1 Proteins)) is required for stimulation of OSR1 (show OXSR1 Proteins) and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (show SLC12A2 Proteins) and NKCC2 activities by osmotic stress.

  8. NKCC1 (show SLC12A2 Proteins) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.

  9. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Proteins)/2 and NCC (show SLC12A3 Proteins) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  10. two mutations in the SLC12A1 among patients suffering from bartter and Gitelman syndromes

Mouse (Murine) Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) interaction partners

  1. Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing.

  2. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  3. our results suggest that NKCCs are involved in insulin (show INS Proteins) secretion and that a single Slc12a2 (show SLC12A2 Proteins) allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1.

  4. Vasopressin (show AVP Proteins) plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport.

  5. In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described.

  6. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase

  7. Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs.

  8. NKCC2A-dependent activation of NFAT5 (show NFAT5 Proteins) is part of a pathway by which the medullary thick ascending limb produces TNF (show TNF Proteins) in response to hypertonic NaCl intake.

  9. Abnormal anterograde trafficking as a common mechanism associated with mutations depriving NKCC2.

  10. NKCC1 (show SLC12A2 Proteins) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.

SLC12A1 Protein Profile

Protein Summary

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Gene names and symbols associated with SLC12A1

  • si:ch211-220f12.1 (si:ch211-220f12.1)
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (SLC12A1)
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1)
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (Slc12a1)
  • solute carrier family 12, member 1 (Slc12a1)
  • AI788571 protein
  • BSC1 protein
  • D630042G03Rik protein
  • DKFZp469A2020 protein
  • mBSC1 protein
  • Nkcc2 protein
  • SLC12A1 protein
  • urehr3 protein

Protein level used designations for SLC12A1

FERM domain-containing protein 4A , Na/K/Cl cotransporter , solute carrier family 12 (sodium/potassium/chloride transporters), member 1 , solute carrier family 12 member 1-like , NKCC2A variant A , Na-K-2Cl cotransporter , bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 , kidney-specific Na-K-Cl symporter , solute carrier family 12 member 1 , Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , apical Na(2Cl)K cotransporter , solute carrier family 12, member 1 , BSC1 , bumetanide-sensitive cotransporter type 1

GENE ID SPECIES
564713 Danio rerio
714289 Macaca mulatta
100025723 Monodelphis domestica
100173185 Pongo abelii
100414428 Callithrix jacchus
100590969 Nomascus leucogenys
6557 Homo sapiens
25065 Rattus norvegicus
415433 Gallus gallus
478292 Canis lupus familiaris
407161 Bos taurus
100328575 Oryctolagus cuniculus
20495 Mus musculus
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