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Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. Additionally we are shipping SLC12A7 Antibodies (74) and SLC12A7 Proteins (10) and many more products for this protein.
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SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis.
The Wnk3 (show WNK3 ELISA Kits) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 ELISA Kits)/2 and NCC (show SLC12A3 ELISA Kits) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
KCC3 (show SLC12A6 ELISA Kits) is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 ELISA Kits) and KCC4 that could result in modulation of KCC activity
Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 (show AQP1 ELISA Kits) water channel (show AQP4 ELISA Kits), revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly.
analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 (show SLC12A5 ELISA Kits) and KCC4
KCC activation by IGF-1 (show IGF1 ELISA Kits) plays an important role in IGF-1 (show IGF1 ELISA Kits) signaling to promote growth and spread of gynecological cancers.
Among patients with early-stage node-negative breast cancer, disease-free survival (DFS (show FST ELISA Kits)) and overall survival (OS) curves were significantly different based on IGF-1 (show IGF1 ELISA Kits) and KCC expression.
KCC4 and H+,K+-ATPase (show ATP1A1 ELISA Kits) are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.
In the metastatic cancer tissues, KCC4 colocalizes with IGF-I (show IGF1 ELISA Kits) or EGF (show EGF ELISA Kits).
Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.
During cell swelling PP1alpha (show PPP1CA ELISA Kits) and PP1gamma1 are involved in KCC4 regulation by WNK4 (show WNK4 ELISA Kits), but that the kinase acts upon these phosphatases to inhibit their activity.
Data are consistent with a role for KCC4 in salt reabsorption of the thick ascending loop of Henle's loop and acid secretion of the collecting duct.
We propose that glycosylation is essential for the surface expression, stabilization, and bioactivity of KCC4
Ste20 (show STK24 ELISA Kits)-related proline-alanine-rich kinase (SPAK (show STK39 ELISA Kits)) and oxidative stress response 1 (OSR1 (show OSR1 ELISA Kits)) with the cotransporters KCC3 (show SLC12A6 ELISA Kits), NKCC1 (show SLC12A2 ELISA Kits), and NKCC2 (show SLC12A1 ELISA Kits) but not KCC1 (show SLC12A4 ELISA Kits) and KCC4
all of the CCCs examined (NKCC1 (show SLC12A2 ELISA Kits), NKCC2 (show SLC12A1 ELISA Kits), KCC1 (show SLC12A4 ELISA Kits), KCC3 (show SLC12A6 ELISA Kits), and KCC4) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
solute carrier family 12 (potassium/chloride transporters), member 7
, K-Cl cotransporter 4
, electroneutral potassium-chloride cotransporter 4
, potassium/chloride transporter KCC4
, solute carrier family 12 member 7
, K-Cl cotransporter KCC4
, furosemide-sensitive KCl cotransporter 4
, potassium-chloride cotransporter