anti-Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Antibodies

SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. Additionally we are shipping Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteins (11) and Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC12A3 6559 P55017
SLC12A3 54300 P55018
SLC12A3 20497 P59158
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Top anti-Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Antibodies at antibodies-online.com

Showing 10 out of 86 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450nm. Formalin-fixed and paraffin embedded human kidney labeled with Anti-SLC12A3 Polyclonal Antibody, Unconjugated (ABIN872340) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Dog Rabbit Un-conjugated IEM, ICC, IF, IHC, WB NCC Western Blotting, rat tissue. 100 μg Log in to see 2 to 3 Days
$394.90
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SLC12A3 Antibody Titration: 0.2-1 ug/mlPositive Control: ACHN cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), WB Anti-SLC12A3 antibody, IHC(F) IHC(F): Rat Kidney Tissue Anti-SLC12A3 antibody, Western blotting Lane 1: NRK Cell Lysate Lane 2: SMMC Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: SLC12A3 Antibody [NBP1-86376] - Staining of human kidney shows strong membranous and cytoplasmic positivity in cells in tubules. Immunocytochemistry/Immunofluorescence: SLC12A3 Antibody [NBP1-86376] - Immunofluorescent staining of human cell line U-251MG shows positivity in nucleus but not nucleoli, cytoplasm & centrosome. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$417.45
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$417.45
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$417.45
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$417.45
Details

SLC12A3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Antibodies

  1. Dog (Canine) Polyclonal SLC12A3 Primary Antibody for IEM, ICC - ABIN863201 : Rosenbaek, Assentoft, Pedersen, MacAulay, Fenton: Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. in The Journal of physiology 2012 (PubMed)
    Show all 10 references for 863201

  2. Human Polyclonal SLC12A3 Primary Antibody for IF (p), IHC (p) - ABIN872340 : Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. in Biology of sex differences 2015 (PubMed)

  3. Human Polyclonal SLC12A3 Primary Antibody for ICC, IF - ABIN4354024 : Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014 (PubMed)

More Antibodies against Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Interaction Partners

Human Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. In wild-type, total (tNCC (show TNNC1 Antibodies)) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a (show AGTR1a Antibodies) receptor knockout mice, tNCC (show TNNC1 Antibodies) and pNCC increased significantly in males to levels not different from those in females.

  2. NCC1 (show CCL13 Antibodies)/2, NCC1 (show CCL13 Antibodies)-3, and pNCC1-3-T55/T60 are upregulated by hydrochlorothiazide, and the increase in NCC abundance in urinary extracellular vesicles of essential hypertensive patients correlates with the blood pressure response to hydrochlorothiazide.

  3. Data show that WNK lysine deficient protein kinase 3 (show WNK3 Antibodies) protein (WNK3 (show WNK3 Antibodies)) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together.

  4. variants of the SLC12A3 gene confer susceptibility to the abnormal serum LDL-c level in the Mongolian population.

  5. A significant association of the SLC12A3 rs11643718 and ELMO1 (show ELMO1 Antibodies) rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.

  6. This paper identified a novel SLC12A3 allele in Gitelman syndrome that activates a cryptic exon flanked by interspersed repeats deep in intron 12.

  7. SLC12A3 gene homozygous mutation is associated with Gitelman syndrome.

  8. SNPs in the SLC12A3 gene confer susceptibility to hypertension in the Mongolian population.

  9. Compared with patients with 1 mutant SLC12A3 allele, patients with 2 mutant SLC12A3 alleles had more severe hypomagnesemia, but did not have more severe hypokalemia.

  10. the results of this study support that the SLC12A3 gene is a susceptibility gene for hypertension in the Mongolian population.

Mouse (Murine) Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 (show KLHL3 Antibodies) and promoting increased blood pressure.

  2. the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4 (show WNK4 Antibodies)-SPAK (show STK39 Antibodies) signal pathway using WNK4 (show WNK4 Antibodies)-/- and SPAK (show STK39 Antibodies)-/- mice.

  3. The Role of Epithelial Sodium Channel ENaC (show SCNN1A Antibodies) and the Apical Cl-/HCO3- Exchanger Pendrin (show SLC26A4 Antibodies) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.

  4. This study identifies NCC as an IL18 (show IL18 Antibodies)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.

  5. Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (show LEPR Antibodies) mice from 6, 12, and 26 weeks at the age.

  6. SPAK (show STK39 Antibodies)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.

  7. NCC inhibition stimulates duodenal Ca(2 (show CA2 Antibodies)+) absorption as well as osteoblast differentiation and bone Ca(2 (show CA2 Antibodies)+) storage, possibly through a FAK (show PTK2 Antibodies)/ERK (show EPHB2 Antibodies) dependent mechanism

  8. P2Y2 (show P2RY2 Antibodies)-mediated increase of cytoplasmic Ca(2 (show CA2 Antibodies)+) concentration down-regulates the expression of NCC.

  9. Estradiol, progesterone, and prolactin (show PRL Antibodies) increase renal NaCl cotransporter phosphorylation and activity.

  10. SPAK (show STK39 Antibodies) is an important mediator of the increased NCC activation by phosphorylation that occurs in the distal convoluted tubule in response to a low-K(+) diet, but other low-potassium-activated kinases are likely to be involved.

Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Antigen Profile

Protein Summary

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC12A3

  • solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3) antibody
  • thiazide-sensitive sodium chloride cotransporter (NCCT) antibody
  • solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 (slc12a3.2) antibody
  • solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3) antibody
  • solute carrier family 12 (sodium/chloride transporter), member 3 (Slc12a3) antibody
  • solute carrier family 12, member 3 (Slc12a3) antibody
  • AI035291 antibody
  • DKFZp469N2315 antibody
  • NCC antibody
  • NCCT antibody
  • slc12a3 antibody
  • TSC antibody

Protein level used designations for SLC12A3

solute carrier family 12 (sodium/chloride transporters), member 3 , thiazide-sensitive sodium chloride cotransporter , solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 , solute carrier family 12 member 3-like , Na-Cl cotransporter , Na-Cl symporter , NaCl electroneutral thiazide-sensitive cotransporter , solute carrier family 12 member 3 , thiazide-sensitive Na-Cl cotransporter , thiazide-sensitive sodium-chloride cotransporter , solute carrier family 12, member 3 , sodium chloride cotransporter

GENE ID SPECIES
415692 Gallus gallus
454108 Pan troglodytes
703090 Macaca mulatta
100009348 Oryctolagus cuniculus
100038063 Xenopus (Silurana) tropicalis
100051953 Equus caballus
100172399 Pongo abelii
100409101 Callithrix jacchus
100468795 Ailuropoda melanoleuca
100015656 Monodelphis domestica
6559 Homo sapiens
54300 Rattus norvegicus
478118 Canis lupus familiaris
404171 Bos taurus
20497 Mus musculus
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