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SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. Additionally we are shipping Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteins (11) and Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Kits (5) and many more products for this protein.
Showing 10 out of 85 products:
Dog (Canine) Polyclonal SLC12A3 Primary Antibody for IEM, ICC - ABIN863201
Rosenbaek, Assentoft, Pedersen, MacAulay, Fenton: Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. in The Journal of physiology 2012
Show all 10 Pubmed References
Human Polyclonal SLC12A3 Primary Antibody for ICC, IF - ABIN4354024
Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014
Human Polyclonal SLC12A3 Primary Antibody for IF (p), IHC (p) - ABIN872340
Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. in Biology of sex differences 2015
Report novel SLC12A3 mutations in Chinese patients with Gitelman syndrome.
we identified a novel SLC12A3 mutation in a Chinese GS pedigree, leading to the substitution of leucine by proline at codon 700 of the NCCT transporter. The proband and his elder sister had a homozygous mutation, while his mother and daughter carried one mutated allele. Because only the proband suffered from bilateral lower limb weakness, we inferred that the same genotype manifests as diverse phenotypes.
MDCKI cells can be used to assess the activity, cellular localization, and abundance of wild-type or mutant NCC.
In wild-type, total (tNCC (show TNNC1 Antibodies)) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a (show AGTR1a Antibodies) receptor knockout mice, tNCC (show TNNC1 Antibodies) and pNCC increased significantly in males to levels not different from those in females.
NCC1 (show CCL13 Antibodies)/2, NCC1 (show CCL13 Antibodies)-3, and pNCC1-3-T55/T60 are upregulated by hydrochlorothiazide, and the increase in NCC abundance in urinary extracellular vesicles of essential hypertensive patients correlates with the blood pressure response to hydrochlorothiazide.
Data show that WNK lysine deficient protein kinase 3 (show WNK3 Antibodies) protein (WNK3 (show WNK3 Antibodies)) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together.
variants of the SLC12A3 gene confer susceptibility to the abnormal serum LDL-c level in the Mongolian population.
A significant association of the SLC12A3 rs11643718 and ELMO1 (show ELMO1 Antibodies) rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.
This paper identified a novel SLC12A3 allele in Gitelman syndrome that activates a cryptic exon flanked by interspersed repeats deep in intron 12.
SLC12A3 gene homozygous mutation is associated with Gitelman syndrome.
Calcineurin is activated by an acute potassium load, which rapidly dephosphorylates NCC, leading to increased urinary potassium excretion.
long-term aldosterone administration stimulates mouse NCC and pT58-NCC abundances in late distal convoluted kidney tubules.
Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 (show KLHL3 Antibodies) and promoting increased blood pressure.
the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4 (show WNK4 Antibodies)-SPAK (show STK39 Antibodies) signal pathway using WNK4 (show WNK4 Antibodies)-/- and SPAK (show STK39 Antibodies)-/- mice.
The Role of Epithelial Sodium Channel ENaC (show SCNN1A Antibodies) and the Apical Cl-/HCO3- Exchanger Pendrin (show SLC26A4 Antibodies) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.
This study identifies NCC as an IL18 (show IL18 Antibodies)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.
Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (show LEPR Antibodies) mice from 6, 12, and 26 weeks at the age.
SPAK (show STK39 Antibodies)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.
NCC inhibition stimulates duodenal Ca(2 (show CA2 Antibodies)+) absorption as well as osteoblast differentiation and bone Ca(2 (show CA2 Antibodies)+) storage, possibly through a FAK (show PTK2 Antibodies)/ERK (show EPHB2 Antibodies) dependent mechanism
P2Y2 (show P2RY2 Antibodies)-mediated increase of cytoplasmic Ca(2 (show CA2 Antibodies)+) concentration down-regulates the expression of NCC.
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
solute carrier family 12 (sodium/chloride transporters), member 3
, thiazide-sensitive sodium chloride cotransporter
, solute carrier family 12 (sodium/chloride transporters), member 3, gene 2
, solute carrier family 12 member 3-like
, Na-Cl cotransporter
, Na-Cl symporter
, NaCl electroneutral thiazide-sensitive cotransporter
, solute carrier family 12 member 3
, thiazide-sensitive Na-Cl cotransporter
, thiazide-sensitive sodium-chloride cotransporter
, solute carrier family 12, member 3
, sodium chloride cotransporter